Categories: Mortality / aging (incl. embryonic lethal) , Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 614304 (gene)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Species-specific description: Xu et al.  (2024) "employed CRISPR/Cas9 and somatic cell nuclear transplantation technologies to successfully generate a knockout miniature pig model of the MIR137 gene, which encodes the neuropsychiatric disorder-associated microRNA miR-137. The homozygous knockout of MIR137 (MIR137^-/-) effectively suppressed the expression of mature miR-137 and led to the birth of stillborn or short-lived piglets. Transcriptomic analysis revealed significant changes in genes associated with neurodevelopment and synaptic signaling in the brains of MIR137^-/- miniature pig, mirroring findings from human ASD [autism spectrum disorders] transcriptomic data." 

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: