In other species: Arabian toothcarp , corn snake

Categories: Skeleton phene (incl. short stature & teeth) , Integument (skin) phene , Limbs / fins / digit / tail phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606603 (gene) , 614940 (trait) , 614941 (trait)

Single-gene trait/disorder: yes

Mode of inheritance: Probably autosomal recessive

Disease-related: yes

Key variant known: yes

Year key variant first reported: 2025

Species-specific symbol: nfr

Molecular basis: Saud et al. (2025) investigated a novel ENU-mutated mangrove killifish line with reduced fin development and identified a likely causal missense variant in the edaradd gene in a highly conserved C-terminal death domain and confirmed the functional effect by creating edaradd CRISPR knock out Arabian killifish. This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Saud et al. (2025): "Nfr mutant presented clear phenotype showing deletion in all fins ... ."

Pathology: Saud et al. (2025): "The phenotype examination in the skin and mouth parts revealed scales were not visible with alizarin red staining and decreasing in the number of teeth in jaws and pharyngeal teeth ... . It was observed remain the big teeth with missing the small one in both jaws and pharyngeal teeth. In addition, there was an obvious and dramatic decrease in the number of gill filaments and gill rakers."

Associated gene: