OMIA:002889-7957 : Skin colour, PAX7-related in Carassius auratus (goldfish) |
In other species: Leopard gecko
Categories: Pigmentation phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 167410 (gene)
Mendelian trait/disorder: yes
Disease-related: unknown
Key variant known: yes
Year key variant first reported: 2024
Species-specific description: Mouri et al. (2024) used CRISPR/Cas9 genome editing to knockout the pax7a and pax7b genes to create transparent goldfish. Leucophore numbers were reduced in pax7b-/- fish but not in pax7a-/- fish. This study involves gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| pax7b | Carassius auratus | - | no genomic information (-..-) | pax7b | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002889-7957: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Mouri, T., Usa, S., Tokumoto, T. : |
| Pax7 is involved in leucophore formation in goldfish and gene knockout improves the transparency of transparent goldfish. Fish Physiol Biochem 50:1701-1710, 2024. Pubmed reference: 38819758. DOI: 10.1007/s10695-024-01364-z. |
Edit History
- Created by Imke Tammen2 on 07 Sep 2024
- Changed by Imke Tammen2 on 07 Sep 2024