OMIA:002920-9986 : Precocious puberty, MKRN3-related in Oryctolagus cuniculus (rabbit) |
Categories: Reproductive system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 615346 (trait) , 603856 (gene)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2025
Species-specific description: Chen et al. (2025) developped a MKRN3-modified rabbit using CRISPR gene editing technology (GMO) as a model for central precocious puberty (CPP) in children.
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MKRN3 | makorin ring finger protein 3 | Oryctolagus cuniculus | 12 | NC_091443.1 (13381554..13387800) | MKRN3 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002920-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2025 | Chen, B., Ye, X., Chen, L., Liu, T., Li, G., Sa, C., Li, J., Liu, K., Gu, W., Wang, G. : |
| A novel model of central precocious puberty disease: Paternal MKRN3 gene-modified rabbit. Animal Model Exp Med , 2025. Pubmed reference: 39854156. DOI: 10.1002/ame2.12544. |
Edit History
- Created by Imke Tammen2 on 29 Jan 2025