Categories: Normal phene

Single-gene trait/disorder: yes

Disease-related: yes

Key variant known: yes

Year key variant first reported: 2025

Cross-species summary: Fish allergens can cause disease in some humans

Species summary: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Molecular basis: Lebret et al. (2025) used Crispr/cas9 gene editing to knock out parvalbumin beta-1 protein, which has been identified as an allergen in some humans. The authors attempted "to delete parvb1 exon 2 encoding the allergenic peptide and, alternatively, to replace exon 2 of parvb1 with exon2 of parvalbumin beta-2 protein (parvb2,) which does not encode the allergenic peptide. ... Genotyping of approximately 200 F0 fingerlings originating from eggs injected with donor DNA designed for exon 2 skipping led to the identification of only one animal carrying an allele lacking exon 2. Genotyping of approximately 150 fingerlings originating from eggs injected with donor DNA for exon 2 swapping did not result in any trout carrying the expected modified allele."

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene: