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OMIA:003032-9913 : Fatty acid desaturase 3 (Fad3), transgenic in Bos taurus (taurine cattle)

Categories: Homeostasis / metabolism phene

Single-gene trait/disorder: unknown

Disease-related: no

Species summary: Su et al. (2025) "created fatty acid desaturase 3 (Fad3) transgenic cattle by utilizing CRISPR-Cas9 technology to insert a codon-optimized Fad3 gene sequence into bovine fibroblast cells and employing somatic cell nuclear transfer (SCNT) technology. Gas chromatographic analysis confirmed that the n-3 PUFA (polyunsaturated fatty acid) content in the transgenic cattle was significantly increased, while the ratio of n-6 PUFAs to n-3 PUFAs decreased." This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003032-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Li, D., Gao, Y., Zhao, X., Yun, Y., Bo, C., Song, L., Yang, L., Bai, C., Li, G., Su, G. :
Endogenous synthesis of n-3 PUFAs can reduce lipid synthesis in Fad3 transgenic cattle. Biochim Biophys Acta Mol Cell Biol Lipids 1870:S1388-1981(25)00080-0:159672, 2025. Pubmed reference: 40738481. DOI: 10.1016/j.bbalip.2025.159672.
Su, G., Wei, Z., Bai, C., Li, D., Zhao, X., Liu, X., Song, L., Zhang, L., Li, G., Yang, L. :
Generation of codon-optimized Fad3 gene transgenic bovine that produce more n-3 polyunsaturated fatty acids. Animals (Basel) 15:93, 2025. Pubmed reference: 39795036. DOI: 10.3390/ani15010093.

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  • Created by Imke Tammen2 on 06 Jan 2026