OMIA:003053-9541 : Neuropsychiatric disorder risk factor, DISC1-related in Macaca fascicularis (crab-eating macaque) |
In other species: Rhesus monkey
Categories: Nervous system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 605210 (gene) , 604906 (trait)
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2026
Molecular basis: Zhou et al. (2026) "generated a germline-transmissible DISC1 mutant model in cynomolgus macaques using CRISPR-Cas9 targeting of exon 9. ... CRISPR-Cas9 editing induced mosaicism with diverse insertion-deletion (indel) mutations ... ." This study involves gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| DISC1 | DISC1 scaffold protein | Macaca fascicularis | 1 | NC_088375.1 (17456037..17054260) | DISC1 | Ensembl, NCBI gene |
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003053-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2026 | Zhou, W., Sun, J., Zuo, G.L., Cai, Y., Li, Y., Li, P., Tan, X., Wu, C., Zhang, R., Zhuang, L., Wang, X., Nie, Y., Wang, Y., Fang, W., Li, C., Wang, Z., Hu, J., Chang, H.C., Xiong, Z., Andolina, I.M., Wang, L., Sun, Q., Luo, Z.G. : |
| DISC1 mutant macaques capture behavioral and neural hallmarks of psychiatric disease. Natl Sci Rev 13:nwag200, 2026. Pubmed reference: 42130747. DOI: 10.1093/nsr/nwag200. |
Edit History
- Created by Imke Tammen on 04 Oct 2026
- Changed by Imke Tammen on 04 Oct 2026