OMIA:003082-9541 : Male infertility, TFDP3-related in Macaca fascicularis (crab-eating macaque) |
Categories: Reproductive system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 300772 (gene)
Single-gene trait/disorder: yes
Disease-related: yes
Key variant known: no
Species summary: Liu et al. (2026): "Tfdp3 deficient cynomolgus monkeys were generated via an in vivo KD system based on the microinjection of Tfdp3-shRNA-containing AAV9 vectors into the seminiferous tubules of the testes of adult male cynomolgus monkeys ... Consistently, dramatic decreases in sperm concentration, motility, and abnormal sperm morphology were ... observed in Tfdp3-KD male cynomolgus monkeys."
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003082-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2026 | Liu, C., Tu, C., Li, P., Wu, H., Wan, F., Lu, Y., Tang, S., Li, X., Li, K., Wang, J., Gao, Y., Geng, X., Meng, L., Zhou, D., Zhou, Y., Zhou, Z., Guo, H., Cao, Y., Jin, L., Li, Z., He, X., Tan, Y.Q., Sun, Q., Zhang, F. : |
| Deficiency of primate-specific TFDP3 causes male infertility with oligoasthenoteratozoospermia in humans and cynomolgus monkeys. Sci China Life Sci 69:1594-1603, 2026. Pubmed reference: 41634254. DOI: 10.1007/s11427-025-3186-2. |
Edit History
- Created by Imke Tammen on 04 Oct 2026
- Changed by Imke Tammen on 04 Oct 2026