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OMIA:003083-9544 : Autism spectrum disorder, ANK2-related in Macaca mulatta (Rhesus monkey)

In other species: crab-eating macaque

Categories: Behaviour / neurological phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 106410 (gene)

Single-gene trait/disorder: yes

Disease-related: yes

Key variant known: no

Species summary: Qin et al. (2021) "evaluated the function of giant ANK2 and its relevance to human nonsyndromic ASDs by using CRISPR/Cas9 gene-edited cynomolgus monkeys (Macaca fascicularis) and rhesus monkeys (Macaca mulatta) in which giant ANK2 was specifically knocked out whilst ANK2 remained intact." This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ANK2 ankyrin 2 Macaca mulatta 5 NC_133410.1 (121949092..122644822) ANK2 Ensembl, NCBI gene

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003083-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2026 Huang, H.D., Ji, Y.C., Zhang, L., Xu, M., Qiao, Y., Li, C.Y., Xie, H.H., Li, Y., Zhang, B.L., Qiu, M.H., Zhang, Y.L., Yu, X.M., Zhang, Y.B., Wang, Y., Wang, Q., Li, Y.J., Lv, L.B., Huang, X.X., Mao, B.Y., Wu, D.D., Zheng, P., Liu, N., Wang, J.H., Yao, Y.G. :
Longitudinal characterization of giant ANK2-depleted monkeys suggests neurodevelopmental-disorder-like phenotypes. Research (Wash D C) 9:1424, 2026. Pubmed reference: 42707610. DOI: 10.34133/research.1424.
2021 Qin, D.D., Zhou, J.K., He, X.C., Shen, X.Y., Li, C., Chen, H.Z., Yan, L.Z., Hu, Z.F., Li, X., Lv, L.B., Yao, Y.G., Wang, Z., Huang, X.X., Hu, X.T., Zheng, P. :
Depletion of giant ANK2 in monkeys causes drastic brain volume loss. Cell Discov 7:113, 2021. Pubmed reference: 34845196. DOI: 10.1038/s41421-021-00336-4.

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  • Created by Imke Tammen on 04 Oct 2026
  • Changed by Imke Tammen on 04 Oct 2026