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OMIA:003097-9940 : Copper toxicosis, generic in Ovis aries (sheep)

Categories: Homeostasis / metabolism phene

Single-gene trait/disorder: unknown

Disease-related: yes

Breed: North Ronaldsay (Sheep) (VBO_0001533).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003097-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2026 Zheng, Z.W., Wu, Z.Y. :
Preclinical models of Wilson's disease: From pathogenesis to clinical translation. Zool Res 47:2095-8137(2026)06-1853-12:1853-1864, 2026. Pubmed reference: 42907939. DOI: 10.24272/j.issn.2095-8137.2025.679.
2013 Haywood, S., Vaillant, C. :
Overexpression of copper transporter CTR1 in the brain barrier of North Ronaldsay sheep: Implications for the study of neurodegenerative disease. J Comp Pathol 150:216-24, 2013. Pubmed reference: 24172593. DOI: 10.1016/j.jcpa.2013.09.002.
2008 Haywood, S., Paris, J., Ryvar, R., Botteron, C. :
Brain copper elevation and neurological changes in north ronaldsay sheep: a model for neurodegenerative disease? J Comp Pathol 139:252-5, 2008. Pubmed reference: 18786681. DOI: 10.1016/j.jcpa.2008.06.008.
2006 Simpson, D.M., Mobasheri, A., Haywood, S., Beynon, R.J. :
A proteomics study of the response of North Ronaldsay sheep to copper challenge. BMC Vet Res 2:36, 2006. Pubmed reference: 17192175. DOI: 10.1186/1746-6148-2-36.
2004 Haywood, S., Müller, T., Mackenzie, A.M., Müller, W., Tanner, M.S., Heinz-Erian, P., Williams, C.L., Loughran, M.J. :
Copper-induced hepatotoxicosis with hepatic stellate cell activation and severe fibrosis in North Ronaldsay lambs: a model for non-Wilsonian hepatic copper toxicosis of infants. J Comp Pathol 130:266-77, 2004. Pubmed reference: 15053929. DOI: 10.1016/j.jcpa.2003.11.005.

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  • Created by Imke Tammen on 26 Oct 2026
  • Changed by Imke Tammen on 26 Oct 2026