Gene MSTN : myostatin in Ovis aries

See the equivalent entry at NCBI

In other species: taurine cattle , dog , pig , chicken , horse , rabbit , goat , water buffalo , Japanese quail , rock pigeon , Japanese flounder

Symbol: MSTN

Synonyms: GDF-8, GDF8

Description: myostatin

Type of gene: protein-coding

NCBI gene id: 443449

Other designations: growth/differentiation factor 8|growth differentiation factor 8

Links: Homologene , Ensembl

Genomic location: 2:119285858..119292614 [Chromosome accession NC_056055.1]

Related phenes:

OMIA:000683-9940 : Muscular hypertrophy (double muscling) in Ovis aries


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Wang, X., Niu, Y., Zhou, J., Yu, H., Kou, Q., Lei, A., Zhao, X., Yan, H., Cai, B., Shen, Q., Zhou, S., Zhu, H., Zhou, G., Niu, W., Hua, J., Jiang, Y., Huang, X., Ma, B., Chen, Y. :
Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. Sci Rep 6:32271, 2016. Pubmed reference: 27562433. DOI: 10.1038/srep32271.
2015 Crispo, M., Mulet, A.P., Tesson, L., Barrera, N., Cuadro, F., dos Santos-Neto, P.C., Nguyen, T.H., Crénéguy, A., Brusselle, L., Anegón, I., Menchaca, A. :
Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes. PLoS One 10:e0136690, 2015. Pubmed reference: 26305800. DOI: 10.1371/journal.pone.0136690.
Lv, X.Y., Sun, W., Su, R., Li, D., Wang, Q.Z., Musa, H.H., Chen, L., Zhang, Y.F., Wu, W.Z. :
Correlation between sheep YAP1 temporal and spatial expression trends and MSTN and MyoG gene expression. Genet Mol Res 14:3244-56, 2015. Pubmed reference: 25966090. DOI: 10.4238/2015.April.13.3.
Proudfoot, C., Carlson, D.F., Huddart, R., Long, C.R., Pryor, J.H., King, T.J., Lillico, S.G., Mileham, A.J., McLaren, D.G., Whitelaw, C.B., Fahrenkrug, S.C. :
Genome edited sheep and cattle. Transgenic Res 24:147-53, 2015. Pubmed reference: 25204701. DOI: 10.1007/s11248-014-9832-x.
2013 Han, J., Forrest, R.H., Hickford, J.G. :
Genetic variations in the myostatin gene (MSTN) in New Zealand sheep breeds. Mol Biol Rep 40:6379-84, 2013. Pubmed reference: 24081623. DOI: 10.1007/s11033-013-2752-7.
Haynes, F.E., Greenwood, P.L., McDonagh, M.B., McMahon, C.D., Nicholas, G.D., Berry, C.J., Oddy, V.H. :
Lack of association between allelic status and myostatin content in lambs with the myostatin g+6723G>A allele. J Anim Sci 91:78-89, 2013. Pubmed reference: 23048142. DOI: 10.2527/jas.2012-5482.
Liu, C., Li, W., Zhang, X., Zhang, N., He, S., Huang, J., Ge, Y., Liu, M. :
Knockdown of endogenous myostatin promotes sheep myoblast proliferation. In Vitro Cell Dev Biol Anim 50:94-102, 2013. Pubmed reference: 24052475. DOI: 10.1007/s11626-013-9689-y.
Zhang, C., Wang, L., Ren, G., Li, Z., Ren, C., Zhang, T., Xu, K., Zhang, Z. :
Targeted disruption of the sheep MSTN gene by engineered zinc-finger nucleases. Mol Biol Rep 41:209-15, 2013. Pubmed reference: 24197697. DOI: 10.1007/s11033-013-2853-3.
2012 Haynes, F.E., Greenwood, P.L., McDonagh, M.B., Oddy, V.H. :
Myostatin allelic status interacts with level of nutrition to affect growth, composition, and myofiber characteristics of lambs. J Anim Sci 90:456-65, 2012. Pubmed reference: 21926323. DOI: 10.2527/jas.2011-4452.
Liu, C., Li, W., Zhang, X., Zhang, N., He, S., Huang, J., Ge, Y., Liu, M. :
The critical role of myostatin in differentiation of sheep myoblasts. Biochem Biophys Res Commun 422:381-6, 2012. Pubmed reference: 22580276. DOI: 10.1016/j.bbrc.2012.04.151.
Lu, J., Sun, D., Xu, L., Lu, G., Zhao, F., Wei, C., Zhang, L., Ding, J., Li, B., Du, L. :
Selection of an effective small interference RNA to silence myostatin gene expression in sheep fibroblast cells. Biochem Genet 50:838-47, 2012. Pubmed reference: 22736258. DOI: 10.1007/s10528-012-9524-2.
Tang, D., Zhu, H., Wu, J., Chen, H., Zhang, Y., Zhao, X., Chen, X., Du, W., Wang, D., Lin, X. :
Silencing myostatin gene by RNAi in sheep embryos. J Biotechnol 158:69-74, 2012. Pubmed reference: 22285957. DOI: 10.1016/j.jbiotec.2012.01.008.
2011 Sjakste, T., Paramonova, N., Grislis, Z., Trapina, I., Kairisa, D. :
Analysis of the single-nucleotide polymorphism in the 5'UTR and part of intron I of the sheep MSTN gene. DNA Cell Biol 30:433-44, 2011. Pubmed reference: 21323579. DOI: 10.1089/dna.2010.1153.
2010 Braunschweig, M.H. :
Mutations in the bovine ABCG2 and the ovine MSTN gene added to the few quantitative trait nucleotides identified in farm animals: a mini-review. J Appl Genet 51:289-97, 2010. Pubmed reference: 20720303. DOI: 10.1007/BF03208858.
2009 Gong, Y.F., Li, X.L., Liu, Z.Z., Jin, X.M., Zhou, R.Y., Li, L.H., Zhang, Q. :
SNP detection and haplotype analysis in partial sequence of MSTN gene in sheep. Genetika 45:1646-9, 2009. Pubmed reference: 20198976.
2008 Zhou, H., Hickford, J.G., Fang, Q. :
Variation in the coding region of the myostatin (GDF8) gene in sheep. Mol Cell Probes 22:67-8, 2008. Pubmed reference: 17935943. DOI: 10.1016/j.mcp.2007.08.004.
2007 Du, R., An, X.R., Chen, Y.F., Qin, J. :
Some motifs were important for myostatin transcriptional regulation in sheep (Ovis aries). J Biochem Mol Biol 40:547-53, 2007. Pubmed reference: 17669271. DOI: 10.5483/bmbrep.2007.40.4.547.
Du, R., An, X., Chen, Y., Qin, J. :
Functional analysis of the Myostatin gene promoter in sheep. Sci China C Life Sci 50:648-54, 2007. Pubmed reference: 17879064. DOI: 10.1007/s11427-007-0085-2.
Ron, M., Weller, J.I. :
From QTL to QTN identification in livestock--winning by points rather than knock-out: a review. Anim Genet 38:429-39, 2007. Pubmed reference: 17697134. DOI: 10.1111/j.1365-2052.2007.01640.x.
Zhang, L., Yang, X., An, X., Chen, Y. :
Myostatin gene targeting in cultured China Han ovine myoblast cells. Animal 1:1401-8, 2007. Pubmed reference: 22444913. DOI: 10.1017/S1751731107000717.
2005 Du, R., Chen, YF., An, XR., Yang, XY., Ma, Y., Zhang, L., Yuan, XL., Chen, LM., Qin, J. :
Cloning and sequence analysis of myostatin promoter in sheep. DNA Seq 16:412-7, 2005. Pubmed reference: 16287620. DOI: 10.1080/10425170500226474.