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OMIA:002773-9031 : T cell deficiency in Gallus gallus (chicken)

Categories: Immune system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: von Heyl et al. (2023): "CRISPR/Cas9 was used to knockout either [alpha/beta] or [gamma/delta] T cells in chickens in order to further analyze the adaptive immune response in poultry. While chickens lacking [gamma/delta] T cells showed no obvious phenotype beside missing [gamma/delta] T cells, birds lacking [alpha/beta] T cells revealed a severe immunophenotype." This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002773-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2023 von Heyl, T., Klinger, R., Aumann, D., Zenner, C., Alhussien, M., Schlickenrieder, A., Lengyel, K., Vikkula, H.K., Mittermair, T., Sid, H., Schusser, B. :
Loss of αβ but not γδ T cells in chickens causes a severe phenotype. Eur J Immunol :e2350503, 2023. Pubmed reference: 37735713. DOI: 10.1002/eji.202350503.

Edit History


  • Created by Imke Tammen2 on 23 Sep 2023
  • Changed by Imke Tammen2 on 18 Dec 2023