OMIA:000008-9685 : Acromegaly in Felis catus (domestic cat)

In other species: dog

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 102200 (trait) , 605555 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Feline hypersomatotropism

Markers: Scudder et al. (2016) obtained some evidence for a genetic contribution to this disorder in cats: "a nonsynonymous AIP single nucleotide polymorphism in 20% of the acromegalic cat population evaluated, as well as in one of the sibling pairs evaluated". A likely causal mutation has yet to be identified.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
AIP aryl hydrocarbon receptor interacting protein Felis catus D1 NC_058377.1 (110104987..110111745) AIP Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000008-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Niessen, S.J.M. :
Hypersomatotropism and other causes of insulin resistance in cats. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 36906467. DOI: 10.1016/j.cvsm.2023.02.005.
2021 GouvĂȘa, F.N., Pennacchi, C.S., Assaf, N.D., de Oliveira Branco, L., Costa, P.B., Reis, P.A.D., Borin-Crivellenti, S. :
Acromegaly in dogs and cats. Ann Endocrinol (Paris) 82:107-111, 2021. Pubmed reference: 33727117. DOI: 10.1016/j.ando.2021.03.002.
2016 Scudder, C.J., Niessen, S.J., Catchpole, B., Fowkes, R.C., Church, D.B., Forcada, Y. :
Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domest Anim Endocrinol 59:134-139, 2016. Pubmed reference: 28119176. DOI: 10.1016/j.domaniend.2016.11.005.
1993 Abramsogg, A.C.G., Holmberg, D.L., Stewart, W.A., Claffey, F.P. :
Acromegaly in a cat - Diagnosis by magnetic resonance imaging and treatment by cryohypophysectomy Canadian Veterinary Journal - Revue Veterinaire Canadienne 34:682-685, 1993.
1990 Peterson, M.E., Taylor, R.S., Greco, D.S., Nelson, R.W., Randolph, J.F., Foodman, M.S., Moroff, S.D., Morrison, S.A., Lothrop, C.D. :
Acromegaly in 14 Cats Journal of Veterinary Internal Medicine 4:192-201, 1990. Pubmed reference: 2401966.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 30 Jan 2017
  • Changed by Imke Tammen2 on 13 Mar 2023