OMIA 000029-9615 : Alloxan-diabetes in Canis lupus familiaris

Mendelian trait/disorder: no

Considered a defect: yes

Key variant known: no

Cross-species summary: Alloxan is an organic compound that causes diabetes mellitus by partial degradation of the beta (β) cells of pancreatic islets, which reduces the quality and quantity of insulin.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1996 Matsunaga, T., Okumura, K., Ishizaka, H., Tsunoda, R., Tayama, S., Tabuchi, T., Yasue, H. :
Impairment of coronary blood flow regulation by endothelium-derived nitric oxide in dogs with alloxan-induced diabetes Journal of Cardiovascular Pharmacology 28:60-67, 1996. Pubmed reference: 8797137.
1995 Damge, C., Hillairebuys, D., Puech, R., Hoeltzel, A., Michel, C., Ribes, G. :
Effects of orally administered insulin nanocapsules in normal and diabetic dogs Diabetes Nutrition & Metabolism 8:3-9, 1995.
1993 Rastogi, K.S., Brubaker, P.L., Kawasaki, A., Efendic, S., Vranic, M. :
Increase in Somatostatin to Glucagon Ratio in Islets of Alloxan-Diabetic Dogs - Effect of Insulin-Induced Euglycemia Canadian Journal of Physiology and Pharmacology 71:512-517, 1993. Pubmed reference: 7902197.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 20 Mar 2022