OMIA 000030-9615 : Alopecia, generic in Canis lupus familiaris

In other species: cattle , sheep , domestic cat , chicken , Rhesus monkey

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104000 , 104100 , 104110 , 104130 , 147770 , 203600 , 203650 , 203655

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Lack of hair or wool or feathers

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 May, E.R., Frank, L.A., Sula, M.M. :
Description and characterization of a hair coat disorder in schipperkes. Vet Dermatol 30:36-e10, 2019. Pubmed reference: 30556622. DOI: 10.1111/vde.12711.
2018 Layne, E.A., Richmond, R.V. :
Deslorelin Implant Treatment for Hair Cycle Arrest (Alopecia X) in Two Intact Male Keeshonden. J Am Anim Hosp Assoc 54:231-234, 2018. Pubmed reference: 29757666. DOI: 10.5326/JAAHA-MS-6646.
2017 Brunner, M.A.T., Jagannathan, V., Waluk, D.P., Roosje, P., Linek, M., Panakova, L., Leeb, T., Wiener, D.J., Welle, M.M. :
Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X. PLoS One 12:e0186469, 2017. Pubmed reference: 29065140. DOI: 10.1371/journal.pone.0186469.
2016 Outerbridge, C.A., White, S.D., Affolter, V.K. :
Alopecia universalis in a dog with testicular neoplasia. Vet Dermatol :, 2016. Pubmed reference: 27644142. DOI: 10.1111/vde.12380.
2015 Berger, D.J., Lewis, T.P., Schick, A.E., Miller, R.I., Loeffler, D.G. :
Canine alopecia secondary to human topical hormone replacement therapy in six dogs. J Am Anim Hosp Assoc 51:136-42, 2015. Pubmed reference: 25695561. DOI: 10.5326/JAAHA-MS-6247.
Stoll, S., Dietlin, C., Nett-Mettler, C.S. :
Microneedling as a successful treatment for alopecia X in two Pomeranian siblings. Vet Dermatol 26:387-90, e88, 2015. Pubmed reference: 26175132. DOI: 10.1111/vde.12236.
2012 [No authors listed] :
Applied dermatology: Postcard presentation: a miniature pinscher with alopecia. Compend Contin Educ Vet 34:E4, 2012. Pubmed reference: 23713156.
Müntener, T., Schuepbach-Regula, G., Frank, L., Rüfenacht, S., Welle, M.M. :
Canine noninflammatory alopecia: a comprehensive evaluation of common and distinguishing histological characteristics. Vet Dermatol 23:206-e44, 2012. Pubmed reference: 22575019. DOI: 10.1111/j.1365-3164.2012.01049.x.
2008 Mausberg, E.M., Drögemüller, C., Dolf, G., Rüfenacht, S., Welle, M., Leeb, T. :
Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden. Vet Rec 163:121-3, 2008. Pubmed reference: 18660523.
2007 Cerundolo, R., Lloyd, D.H., Vaessen, M.M., Mol, J.A., Kooistra, H.S., Rijnberk, A. :
Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback. Vet Rec 160:393-7, 2007. Pubmed reference: 17384290.
Mausberg, E.M., Drögemuller, C., Rüfenacht, S., Welle, M., Roosje, P., Suter, M., Leeb, T. :
[Inherited alopecia X in Pomeranians]. Dtsch Tierarztl Wochenschr 114:129-34, 2007. Pubmed reference: 17484499.
Mausberg, E.M., Drögemüller, C., Leeb, T., Dolf, G., Rüfenacht, S., Welle, M. :
Evaluation of the CTSL2 gene as a candidate gene for alopecia X in Pomeranians and Keeshonden. Anim Biotechnol 18:291-6, 2007. Pubmed reference: 17934903. DOI: 10.1080/10495390701547461.
2006 Frank, L.A., Donnell, R.L., Kania, S.A. :
Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation. Vet Dermatol 17:252-8, 2006. Pubmed reference: 16827668. DOI: 10.1111/j.1365-3164.2006.00520.x.
2005 Bassett, RJ., Burton, GG., Robson, DC. :
Recurrent flank alopecia in a Tibetan Terrier. Aust Vet J 83:276-9, 2005. Pubmed reference: 15957387.
Cerundolo, R., Mauldin, EA., Goldschmidt, MH., Beyerlein, SL., Refsal, KR., Oliver, JW. :
Adult-onset hair loss in Chesapeake Bay retrievers: a clinical and histological study. Vet Dermatol 16:39-46, 2005. Pubmed reference: 15725104. DOI: 10.1111/j.1365-3164.2005.00432.x.
Frank, LA. :
Growth hormone-responsive alopecia in dogs. J Am Vet Med Assoc 226:1494-7, 2005. Pubmed reference: 15881999.
2004 Frank, LA., Hnilica, KA., Oliver, JW. :
Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. Vet Dermatol 15:278-84, 2004. Pubmed reference: 15500479. DOI: 10.1111/j.1365-3164.2004.00372.x.
2003 Frank, L.A., Hnilica, K.A., Rohrbach, B.W., Oliver, J.W. :
Retrospective evaluation of sex hormones and steroid hormone intermediates in dogs with alopecia Veterinary Dermatology 14:91-7, 2003. Pubmed reference: 12662266.
2002 Takada, K., Kitamura, H., Takiguchi, M., Saito, M., Hashimoto, A. :
Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians Research in Veterinary Science 73:159-163, 2002. Pubmed reference: 12204635.
2001 Lloyd, D.H., Cerundolo, R. :
Alopecia X in dogs. Vet Rec 148:60, 2001. Pubmed reference: 11202560.
2000 Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom Veterinary Dermatology 11:107-122, 2000.
Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000) Veterinary Dermatology 11:313-314, 2000.
1999 De, Jonghe, S.R., Ducatelle, R.V., Mattheeuws, D.R. :
Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback Veterinary Dermatology 10:123-126, 1999.
Stratakis, C.A., Rennert, O.M. :
Congenital adrenal hyperplasia: molecular genetics and alternative approaches to treatment. Crit Rev Clin Lab Sci 36:329-63, 1999. Pubmed reference: 10486704. DOI: 10.1080/10408369991239222.
1998 Cerundolo, R., Lloyd, D. :
Alopecia X in Chows, Pomeranians and Samoyeds Veterinary Record 143:176, 1998. Pubmed reference: 9746955.
1997 Declercq, J. :
Alopecia in German Shepherds [Dutch] Vlaams Diergeneeskundig Tijdschrift 66:97, 1997.
1996 Curtis, C.F., Evans, H., Lloyd, D.H. :
Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia Journal of Small Animal Practice 37:417-422, 1996. Pubmed reference: 8887201.
1995 Allan, F.J., Jones, B.R., Purdie, E.C. :
Endocrine alopecia in a Miniature Poodle New Zealand Veterinary Journal 43:110-113, 1995.
Miller, W.H., Scott, D.W. :
Follicular dysplasia of the portuguese water dog Veterinary Dermatology 6:67-74, 1995.
Waldman, L. :
Seasonal flank alopecia in affenpinschers Journal of Small Animal Practice 36:271-273, 1995. Pubmed reference: 7650925.
1994 Vandenbroek, A.H.M. :
Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal Alopecia Veterinary Record 134:277-278, 1994. Pubmed reference: 8197698.
1991 Miller, W.H. :
Alopecia Associated with Coat Color Dilution in 2 Yorkshire Terriers, One Saluki, and One Mix-Breed Dog Journal of the American Animal Hospital Association 27:39-43, 1991.
1990 Schmeitzel, L.P., Lothrop, C.D. :
Hormonal abnormalities in Pomeranians with normal coat and in Pomeranians with growth hormone-responsive dermatosis. J Am Vet Med Assoc 197:1333-41, 1990. Pubmed reference: 2176197.
1989 Coward, P.S. :
A Familial Alopecia Veterinary Record 125:609-610, 1989. Pubmed reference: 2609495.
1967 Dämmrich, K. :
[On alopecia in dogs]. Berl Munch Tierarztl Wochenschr 80:373-7, 1967. Pubmed reference: 5628512.

Edit History


  • Created by Mohammad Shariflou on 23 Jul 2007
  • Changed by Frank Nicholas on 05 Aug 2013