OMIA:000052-9615 : Aortic stenosis, subvalvular in Canis lupus familiaris (dog)

Categories: Cardiovascular system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: "Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs ... that can result in fainting, a shortened life span, or sudden death. ... The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity." (Ontiveros and Stern, 2021) See also OMIA:000952-9615 : Subaortic stenosis in Canis lupus familiaris

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Prevalence: "The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital." (Ontiveros and Stern, 2021)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000052-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Aherne, M. :
Cardiac disease and screening in breeding dogs. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 37353418. DOI: 10.1016/j.cvsm.2023.05.001.
Crofton, A.E., Kovacs, S.L., Stern, J.A. :
Subvalvular aortic stenosis: Learning from human and canine clinical research. Cardiol Res 14:319-333, 2023. Pubmed reference: 37936623. DOI: 10.14740/cr1547.
2021 Ontiveros, E.S., Stern, J.A. :
Genetics of canine subvalvular aortic stenosis (SAS). Canine Med Genet 8:4, 2021. Pubmed reference: 33962679. DOI: 10.1186/s40575-021-00103-4.
2020 Brambilla, P.G., Polli, M., Pradelli, D., Papa, M., Rizzi, R., Bagardi, M., Bussadori, C. :
Epidemiological study of congenital heart diseases in dogs: Prevalence, popularity, and volatility throughout twenty years of clinical practice. PLoS One 15:e0230160, 2020. Pubmed reference: 32716943. DOI: 10.1371/journal.pone.0230160.
2019 Ontiveros, E.S., Fousse, S.L., Crofton, A.E., Hodge, T.E., Gunther-Harrington, C.T., Visser, L.C., Stern, J.A. :
Congenital cardiac outflow tract abnormalities in dogs: Prevalence and pattern of inheritance from 2008 to 2017. Front Vet Sci 6:52, 2019. Pubmed reference: 30873420. DOI: 10.3389/fvets.2019.00052.
2017 Belanger, J.M., Bellumori, T.P., Bannasch, D.L., Famula, T.R., Oberbauer, A.M. :
Correlation of neuter status and expression of heritable disorders. Canine Genet Epidemiol 4:6, 2017. Pubmed reference: 28560045. DOI: 10.1186/s40575-017-0044-6.
2015 Oberbauer, A.M., Belanger, J.M., Bellumori, T., Bannasch, D.L., Famula, T.R. :
Ten inherited disorders in purebred dogs by functional breed groupings. Canine Genet Epidemiol 2:9, 2015. Pubmed reference: 26401337. DOI: 10.1186/s40575-015-0021-x.
Schrope, D.P. :
Prevalence of congenital heart disease in 76,301 mixed-breed dogs and 57,025 mixed-breed cats. J Vet Cardiol 17:192-202, 2015. Pubmed reference: 26363941. DOI: 10.1016/j.jvc.2015.06.001.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
2011 Oliveira, P., Domenech, O., Silva, J., Vannini, S., Bussadori, R., Bussadori, C. :
Retrospective review of congenital heart disease in 976 dogs. J Vet Intern Med 25:477-83, 2011. Pubmed reference: 21418326. DOI: 10.1111/j.1939-1676.2011.0711.x.
2009 Bussadori, C., Pradelli, D., Borgarelli, M., Chiavegato, D., D'Agnolo, G., Menegazzo, L., Migliorini, F., Santilli, R., Zani, A., Quintavalla, C. :
Congenital heart disease in boxer dogs: results of 6 years of breed screening. Vet J 181:187-92, 2009. Pubmed reference: 18400530. DOI: 10.1016/j.tvjl.2008.02.008.
2007 Höglund, K., Bussadori, C., Domenech, O., Häggström, J., Pradelli, D., Kvart, C. :
Contrast echocardiography in Boxer dogs with and without aortic stenosis. J Vet Cardiol 9:15-24, 2007. Pubmed reference: 17689465. DOI: 10.1016/j.jvc.2006.02.003.
2006 Linde, A., Koch, J. :
Screening for aortic stenosis in the Boxer: Auscultatory, ECG, blood pressure and Doppler echocardiographic findings. J Vet Cardiol 8:79-86, 2006. Pubmed reference: 19083341. DOI: 10.1016/j.jvc.2006.02.002.
2002 Schober, KE., Fuentes, VL. :
Doppler echocardiographic assessment of left ventricular diastolic function in 74 boxer dogs with aortic stenosis. J Vet Cardiol 4:7-16, 2002. Pubmed reference: 19081341. DOI: 10.1016/S1760-2734(06)70018-2.
2000 French, A., Fuentes, V.L., Dukes-McEwan, J., Darke, P.G.G., Martin, M., Corcoran, B. :
Progression of aortic stenosis in the boxer Journal of Small Animal Practice 41:451-456, 2000. Pubmed reference: 11072913.
Heiene, R., Kvart, C., Indrebo, A., Skaalnes, H.M., Ulstad, A.K. :
Prevalence of murmurs consistent with aortic stenosis among boxer dogs in Norway and Sweden Veterinary Record 147:152-156, 2000. Pubmed reference: 10975330.
1998 Delpalacio, M.J.F., Bayon, A., Bernal, L.J., Ceron, J.J., Navarro, J.A. :
Clinical and pathological findings of severe subvalvular aortic stenosis and mitral dysplasia in a rottweiler puppy Journal of Small Animal Practice 39:481-485, 1998. Pubmed reference: 9816571.
Kvart, C., French, A.T., Fuentes, V.L., Haggstrom, J., Mcewan, J.D., Schober, K.E. :
Analysis ofmurmur intensity, duration and frequency components in dogs with aortic stenosis Journal of Small Animal Practice 39:318-324, 1998. Pubmed reference: 9693417.
1997 Monnet, E. :
Open resection for subvalvular aortic stenosis in dogs (vol 209, pg 1255, 1996) Journal of the American Veterinary Medical Association 210:92, 1997.
Tidholm, A. :
Retrospective study of congenital heart defects in 151 dogs Journal of Small Animal Practice 38:94-98, 1997. Pubmed reference: 9097239.
White, R.N., Boswood, A., Garden, O.A., Hammond, R.A. :
Surgical management of subvalvular aortic stenosis and mitral dysplasia in a golden retriever Journal of Small Animal Practice 38:251-255, 1997. Pubmed reference: 9200115.
1995 Skarda, R.T., Bednarski, R.M., Muir, W.W., Hubbell, J.A.E., Mason, D.E. :
Sedation and anesthesia in dogs and cats with cardiovascular disease Schweizer Archiv Fur Tierheilkunde 137:312-321, 1995. Pubmed reference: 7569846.
1994 Buoscio, D.A., Sisson, D., Zachary, J.F., Luethy, M. :
Clinical and Pathological Characterization of an Unusual Form of Subvalvular Aortic Stenosis in 4 Golden Retriever Puppies Journal of the American Animal Hospital Association 30:100-110, 1994.
1989 Muir, G.D., Panciera, D.L., Fowler, J.D., Bharadwaj, B.B., Burrows, P. :
Medical and Surgical Management of Aortic Stenosis in a Dog Canadian Veterinary Journal-Revue Veterinaire Canadienne 30:894-896, 1989.
O'Grady, M.R., Holmberg, D.L., Miller, C.W., Cockshutt, J.R. :
Canine Congenital Aortic Stenosis - A Review of the Literature and Commentary Canadian Veterinary Journal-Revue Veterinaire Canadienne 30:811-815, 1989.
1973 Mulvihill, J.J., Priester, W.A. :
Congenital heart disease in dogs: epidemiologic similarities to man. Teratology 7:73-7, 1973. Pubmed reference: 4693746. DOI: 10.1002/tera.1420070111.
1971 Rudolph, R. :
[Subvalvular aortic stenosis in a 4-year-old female German boxer]. Berl Munch Tierarztl Wochenschr 84:374-5, 1971. Pubmed reference: 5107230.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 26 May 2021
  • Changed by Imke Tammen2 on 08 Feb 2024