OMIA:000082-9615 : Atopy in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Integument (skin) phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 147050 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Mapping: By conducting a GWAS on "31 high-IgE and 24 low-IgE responder" West Highland White Terrier dogs, each genotyped with the Affymetrix V2 Dog SNP chip (yielding 48,157 informative SNPs for analysis), Barros Roque et al. (2011) highlighted a 2.3Mb region on chromosome CFA35. A polymorphism within a nearby positional candidate gene, CD83, was shown not to be causal.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000082-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2015 Oberbauer, A.M., Belanger, J.M., Bellumori, T., Bannasch, D.L., Famula, T.R. :
Ten inherited disorders in purebred dogs by functional breed groupings. Canine Genet Epidemiol 2:9, 2015. Pubmed reference: 26401337. DOI: 10.1186/s40575-015-0021-x.
2013 Bellumori, T.P., Famula, T.R., Bannasch, D.L., Belanger, J.M., Oberbauer, A.M. :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013. Pubmed reference: 23683021. DOI: 10.2460/javma.242.11.1549.
Olivry, T., Bizikova, P., Paps, J.S., Dunston, S., Lerner, E.A., Yosipovitch, G. :
Cowhage can induce itch in the atopic dog. Exp Dermatol 22:435-7, 2013. Pubmed reference: 23711071. DOI: 10.1111/exd.12158.
2011 Barros Roque, J., O'Leary, C.A., Duffy, D.L., Kyaw-Tanner, M., Latter, M., Mason, K., Vogelnest, L., Shipstone, M. :
IgE Responsiveness to Dermatophagoides farinae in West Highland White Terrier Dogs Is Associated with Region on CFA35. J Hered :S74-80, 2011. Pubmed reference: 21846750. DOI: 10.1093/jhered/esr054.
2003 Foster, A.P., Littlewood, J.D., Webb, P., Wood, J.L., Rogers, K., Shaw, S.E. :
Comparison of intradermal and serum testing for allergen-specific IgE using a Fcepsilon RIalpha-based assay in atopic dogs in the UK Veterinary Immunology & Immunopathology 93:51-60, 2003.
Fraser, M.A., McNeil, P.E., Gettinby, G. :
Studies of serum total immunoglobulin E concentrations in atopic and non-atopic dogs Veterinary Record 152:159-163, 2003. Pubmed reference: 12622285.
2002 Bond, R., Curtis, C.F., Hendricks, A., Ferguson, E.A., Lloyd, D.H. :
Intradermal test reactivity to Malassezia pachydermatis in atopic dogs Veterinary Record 150:448-+, 2002. Pubmed reference: 11993975.
Maeda, S., Okayama, T., Omori, K., Masuda, K., Sakaguchi, M., Ohno, K., Tsujimoto, H. :
Expression of CC chemokine receptor 4 (CCR4) mRNA in canine atopic skin lesion Veterinary Immunology & Immunopathology 90:145-154, 2002.
Mueller, R.S., Chapman, P.L., Rosychuk, R.E.W., Bettenay, S.V., Fieseler, K.V. :
Evaluation of cross-reactivity of allergens by use of intradermal testing in atopic dogs American Journal of Veterinary Research 63:874-879, 2002. Pubmed reference: 12061535.
Saevik, B.K., Thoresen, S.I., Kristensen, F. :
A retrospective study of hyposensitization in canine atopy based on a polyclonal ELISA test Veterinary Research Communications 26:613-624, 2002. Pubmed reference: 12507036.
Teuber, S.S., del, Val, G., Morigasaki, S., Jung, H.R., Eisele, P.H., Frick, O.L., Buchanan, B.B. :
The atopic dog as a model of peanut and tree nut food allergy Journal of Allergy & Clinical Immunology 110:921-927, 2002.
Youn, H., Kang, H., Bhang, D., Kim, M., Hwang, C., Han, H. :
Allergens causing atopic diseases in canine Journal of Veterinary Science 3:335-341, 2002. Pubmed reference: 12819384.
2001 Changoda, P., Kozak, M., Varga, G., Skalka, J. :
Epidemiology of atopic diseases in dogs in Slovakia during 1995-2000 Acta Veterinaria-Beograd 51:101-106, 2001.
2000 Hilsenroth, R. :
Canine atopy Canine Practice 25:24, 2000.
Masuda, K., Sakaguchi, M., Saito, S., Deboer, D.J., Fujiwara, S., Kurata, K., Yamashita, K., Hasegawa, A., Ohno, K., Tsujimoto, H. :
In vivo and in vitro tests showing sensitization to Japanese cedar (Cryptomeria japonica) pollen allergen in atopic dogs Journal of Veterinary Medical Science 62:995-1000, 2000. Pubmed reference: 11039597.
Masuda, K., Sakaguchi, M., Fujiwara, S., Kurata, K., Yamashita, K., Odagiri, T., Nakao, Y., Matsuki, N., Ono, K., Watari, T., Hasegawa, A., Tsujimoto, H. :
Positive reactions to common allergens in 42 atopic dogs in Japan Veterinary Immunology & Immunopathology 73:193-204, 2000.
Park, S.J., Ohya, F., Yamashita, K., Nishifuji, K., Iwasaki, T. :
Comparison of response to immunotherapy by intradermal skin test and antigen-specific IgE in canine atopy Journal of Veterinary Medical Science 62:983-988, 2000. Pubmed reference: 11039595.
Scott, D.W., Rothstein, E., Miller, W.H. :
A clinical study on the efficacy of two commercial veterinary pramoxine cream rinses in the management of pruritus in atopic dogs Canine Practice 25:15-17, 2000.
1999 Harvey, R.G. :
A blinded, placebo-controlled study of the efficacy of borage seed oil and fish oil in the management of canine atopy Veterinary Record 144:405-407, 1999. Pubmed reference: 10331227.
Mueller, R.S., Burrows, A., Tsohalis, J. :
Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs Australian Veterinary Journal 77:290-294, 1999. Pubmed reference: 10376096.
Olivry, T., Dean, G.A., Tompkins, M.B., Dow, J.L., Moore, P.F. :
Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs Experimental Dermatology 8:204-211, 1999. Pubmed reference: 10389638.
Rosser, E.J. :
Advances in the diagnosis and treatment of atopy Veterinary Clinics of North America - Small Animal Practice 29:1437-+, 1999.
1998 Lian, T.M., Halliwell, R.E.W. :
Allergen-specific IgE and IgGd antibodies in atopic and normal dogs Veterinary Immunology & Immunopathology 66:203-223, 1998.
Morris, D.O., Olivier, N.B., Rosser, E.J. :
TYPE-1 hypersensitivity reactions to malassezia pachydermatis extracts in atopic dogs American Journal of Veterinary Research 59:836-841, 1998. Pubmed reference: 9659547.
Nuttall, T.J., Thoday, K.L., Vandenbroek, A.H.M., Jackson, H.A., Sture, G.H., Halliwell, R.E.W. :
Retrospective survey of allergen immunotherapy in canine atopy Veterinary Record 143:139-142, 1998. Pubmed reference: 9725186.
1997 Burton, G. :
Sarcoptic mange and iatrogenic hyperadrenocorticoidism in a dog undergoing hyposensitisation for atopy based on rast testing Australian Veterinary Practitioner 27:27 ff., 1997.
Deweck, A.L., Mayer, P., Stumper, B., Schiessl, B., Pickart, L. :
Dog allergy, a model for allergy genetics International Archives of Allergy & Immunology 113:55-57, 1997.
Ermel, R.W., Kock, M., Griffey, S.M., Reinhart, G.A., Frick, O.L. :
The atopic dog - a model for food allergy Laboratory Animal Science 47:40-49, 1997. Pubmed reference: 9051646.
Marsella, R., Kunkle, G.A., Vaughn, D.M., Macdonald, J. :
Double-blind pilot study on the effects of ketoconazole on intradermal skin test and leukotriene C-4 concentration in the skin of atopic dogs Veterinary Dermatology 8:3-10, 1997.
Mueller, R.S., Cannon, A., Reubl, G.H., Ihrke, P.J. :
Serum and skin IgA concentrations in normal and atopic dogs Australian Veterinary Journal 75:906-909, 1997. Pubmed reference: 9469228.
Olivry, T., Guaguere, E., Heripret, D. :
Treatment of canine atopic dermatitis with misoprostol, a prostaglandin E-1 analogue - an open study Journal of Dermatological Treatment 8:243-247, 1997.
Perkins, J. :
Diagnosis of atopy in dogs - a review of the need for conceptual and diagnostic refinement Australian Veterinary Practitioner 27:8-14, 1997.
Scott, D.W., Miller, W.H., Reinhart, G.A., Mohammed, H.O., Bagladi, M.S. :
Effect of an OMEGA-3/OMEGA-6 fatty acid-containing commercial lamb and rice diet on pruritus in atopic dogs - results of a single-blinded study Canadian Journal of Veterinary Research - Revue Canadienne de Recherche Veterinaire 61:145-153, 1997. Pubmed reference: 9114966.
1996 Day, M.J., Corato, A., Shaw, S.E. :
Subclass profile of allergen-specific igg antibodies in atopic dogs Research in Veterinary Science 61:136-142, 1996. Pubmed reference: 8880983.
Mueller, R.S., Bettenay, S.V. :
Long-term immunotherapy of 146 dogs with atopic dermatitis - a retrospective study Australian Veterinary Practitioner 26:128-132, 1996.
1967 Schwartzman, R.M., Rockey, J.H. :
Atopy in the dog Archives of Dermatology 96:418-422, 1967.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 22 May 2013