OMIA:000177-9615 : Cerebellar cortical atrophy in Canis lupus familiaris |
In other species: domestic cat , cattle , sheep
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: no
Cross-species summary: Wasting (decrease) of the outer layer of the grey matter of the cerebellum (the part of the brain situated behind the two hemispheres and above the pons and medulla oblongata).
Inheritance: Olby et a. (2004) provided reasonable evidence supporting autosomal recessive inheritance in a family of American Staffordshire Terriers. A likely disease causing mutation has been identified in this breed - see 'lysosomal storage disease, ARSG related' (OMIA001503-9615) for further details.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2007 | Nibe, K., Kita, C., Morozumi, M., Awamura, Y., Tamura, S., Okuno, S., Kobayashi, T., Uchida, K. : |
| Clinicopathological features of canine neuroaxonal dystrophy and cerebellar cortical abiotrophy in Papillon and Papillon-related dogs. J Vet Med Sci 69:1047-52, 2007. Pubmed reference: 17984592 . | |
| 2006 | Buijtels, J.J., Kroeze, E.J., Voorhout, G., Schellens, C.J., van Nes, J.J. : |
| [Cerebellar cortical degeneration in an American Staffordshire terrier]. Tijdschr Diergeneeskd 131:518-22, 2006. Pubmed reference: 16916197 . | |
| 2004 | Olby, N., Blot, S., Thibaud, JL., Phillips, J., O'Brien, DP., Burr, J., Berg, J., Brown, T., Breen, M. : |
| Cerebellar cortical degeneration in adult American Staffordshire Terriers. J Vet Intern Med 18:201-8, 2004. Pubmed reference: 15058771 . | |
| 2003 | Hanzlicek, D., Kathmann, I., Bley, T., Srenk, P., Botteron, C., Gaillard, C., Jaggy, A. : |
| [Cerebellar cortical abiotrophy in American Staffordshire terriers: clinical and pathological description of 3 cases] Schweizer Archiv fur Tierheilkunde 145:369-75, 2003. Pubmed reference: 12951908 . | |
| 2000 | van, Tongeren, S.E., van, Vonderen, I.K., van, Nes, J.J., van, den, Ingh, T.S.G.A.M. : |
| Cerebellar cortical abiotrophy in two Portuguese Podenco littermates Veterinary Quarterly 22:172-174, 2000. Pubmed reference: 10952450 . | |
| 1991 | Perille, A.L., Baer, K., Joseph, R.J., Carrillo, J.M., Averill, D.R. : |
| Postnatal Cerebellar Cortical Degeneration in Labrador Retriever Puppies Canadian Veterinary Journal - Revue Veterinaire Canadienne 32:619-621, 1991. |
Edit History
- Created by Frank Nicholas on 27 Oct 2005
- Changed by Imke Tammen2 on 08 Jan 2021