In other species: dog , domestic cat

Categories: Integument (skin) phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608245 (gene)

Single-gene trait/disorder: unknown

Disease-related: no

Key variant is published: no

Species summary: Information relating to curly coat in horses due to variants in KRT25 and SP6 was previously listed here but has been moved to gene specific entries [13/02/2026] - see OMIA:003039-9796 : Curly coat, KRT25-related in Equus caballus (domestic horse) and OMIA:002175-9796 : Curly coat, SP6-related in Equus caballus (domestic horse).

Inheritance: Morgenthaler et al (2017): "in North American horses, the most frequent Curly coat phenotype is described as autosomal dominant (Crd) [Sponenberg, 1990], whereas recessive forms have been reported to segregate in the Quarter Horse, Arabian, Appaloosa, Missouri Fox Trotter, Tennessee Walking Horse, Paint, Morgan and Paso Fino breeds [Sponenberg, 1990] as well as in French Percheron horses [Blakeslee et al., 1943]."

Molecular basis: For information on likely causal variants in KRT25 and SP6 which were previously listed here see OMIA:003039-9796 : Curly coat, KRT25-related in Equus caballus (domestic horse) and OMIA:002175-9796 : Curly coat, SP6-related in Equus caballus (domestic horse).

Breeds: American Paint (Horse) (VBO_0000897), Appaloosa (Horse) (VBO_0000904), Arab (Horse) (VBO_0000905), Missouri Fox Trotting Horse (Horse) (VBO_0017148), Paso Fino (Horse) (VBO_0001040), Percheron (Horse) (VBO_0001041), Quarter Horse (Horse) (VBO_0001057), Tennessee Walking Horse (Horse) (VBO_0001081).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).