OMIA:000247-9615 : Cushing disease, pituitary-dependent hyperadrenocorticism in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 160980 (trait) , 219080 (trait) , 219090 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Entries for Cushing disease (pituitary-dependent hyperadrenocorticism) are included for some species under the phene 'Hyperadrenocorticism, generic' (or Cushing syndrome): OMIA:000494.

Molecular basis: De-Marco et al. (2017) searched for variants in the coding region of the functional comparative candidate gene CRHR1 in 50 Poodles with pituitary-dependent hyperadrenocorticism and 50 control Poodles. An activating heterozygous mutation was identified in exon 4 of the CRHR1 gene in one of the affected poodles, and these findings were supported by protein modelling and functional characterisation of the mutant protein. The other 49 affected dogs lacked the variant and further evidence is required before any conclusions can be drawn about the relevance of this variant to pituitary hyperadrenocorticism in the wider poodle population (Heidi Schmeck 3/11/2020).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000247-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Burbaitė, E., Fiorentino, E., Negro, L., Menchetti, M. :
Stiffness of the four limbs in a Jack Russell Terrier dog. J Am Vet Med Assoc 262:139-141, 2024. Pubmed reference: 38103386. DOI: 10.2460/javma.23.07.0424.
2023 Bunn, T., Langner, K., Foster, S., Hayward, D., Howard, G., Paltrinieri, S., Giordano, A., Rossi, G. :
Lipoprotein profiles in Miniature Schnauzer dogs with idiopathic hypertriglyceridemia and hypercortisolism. J Vet Diagn Invest :10406387231217505, 2023. Pubmed reference: 38111301. DOI: 10.1177/10406387231217505.
Fleeman, L., Barrett, R. :
Cushing syndrome and other causes of insulin resistance in dogs. Vet Clin North Am Small Anim Pract , 2023. Pubmed reference: 36898861. DOI: 10.1016/j.cvsm.2023.01.009.
2021 De Ravin, E., Phan, H.A.T., Harmsen, S., Cho, S.S., Teng, C.W., Petersson, E.J., White, C., Galban, E.M., Hess, R., Lee, J.Y.K. :
Somatostatin receptor as a molecular imaging target in human and canine Cushing disease. World Neurosurg 149:94-102, 2021. Pubmed reference: 33601082. DOI: 10.1016/j.wneu.2021.02.034.
Wang, A., Neill, S.G., Newman, S., Tryfonidou, M.A., Ioachimescu, A., Rossi, M.R., Meij, B.P., Oyesiku, N.M. :
The genomic profiling and MAMLD1 expression in human and canines with Cushing's disease. BMC Endocr Disord 21:185, 2021. Pubmed reference: 34517852. DOI: 10.1186/s12902-021-00845-z.
2016 Nolte, A., Strube, C., Raue, K., Brämer, C., Baumgärtner, W., Wohlsein, P. :
[Subcutaneous Taenia crassiceps-cysticercosis in a dog with Cushing's syndrome]. Tierarztl Prax Ausg K Kleintiere Heimtiere 44:53-8, 2016. Pubmed reference: 26763526. DOI: 10.15654/TPK-150145.
2011 Gilor, C., Graves, TK. :
Interpretation of Laboratory Tests for Canine Cushing's Syndrome. Top Companion Anim Med 26:98-108, 2011. Pubmed reference: 21596349. DOI: 10.1053/j.tcam.2011.03.001.
2005 Granger, N., de Fornel, P., Devauchelle, P., Segond, S., Delisle, F., Rosenberg, D. :
Plasma pro-opiomelanocortin, pro-adrenocorticotropin hormone, and pituitary adenoma size in dogs with Cushing's disease. J Vet Intern Med 19:23-8, 2005. Pubmed reference: 15715043.
2001 Meij, B.P. :
Hypophysectomy as a treatment for canine and feline Cushing's disease Veterinary Clinics of North America - Small Animal Practice 31:1015-+, 2001.
Peterson, M.E. :
Medical treatment of canine pituitary dependent hyperadrenocorticism (Cushing's disease) Veterinary Clinics of North America - Small Animal Practice 31:1005-+, 2001.
Reusch, C. :
Modern diagnosis and treatment of canine Cushing syndrome Magyar Allatorvosok Lapja 123:222-224, 2001.
Reusch, C., Glaus, T., Wess, G., Tomsa, K., Horauf, A., Stankeova, S., Geissbuhler, U., Kaser-Hotz, B. :
Clinical, routine laboratory and specific endocrine investigations in dogs with pituitary-dependent Cushing's syndrome: A comparison between dogs with macro- and dogs with microtumors. Kleintierpraxis 46:261-+, 2001.
Reusch, C., Stankeova, S., Geissbuhler, U., Glaus, T., Tomsa, K., Horauf, A., Kaser-Hotz, B. :
Correlation between pituitary size measured by computed tomography and neurological symptoms in dogs with Cushing's syndrome Kleintierpraxis 46:133-+, 2001.
2000 Ottenjann, M., Munster, M. :
Mitotane monotherapy of canine Cushing's syndrome: Evaluation of a short initial therapy protocol on 20 outpatient patients [German] Kleintierpraxis 45:511-+, 2000.
1998 Barry, P. :
Hyperadrenocorticism (HAC) in the dog - cushings-syndrome Irish Veterinary Journal 51:489-490, 1998.
Behrend, E.N., Kemppainen, R.J. :
Medical therapy of canine cushings-syndrome Compendium on Continuing Education for the Practicing Veterinarian 20:679 ff., 1998.
Gfeller, G., Reusch, C. :
Case report from small animal practice [German] Schweizer Archiv fur Tierheilkunde 140:375-379, 1998. Pubmed reference: 9757786.
Meij, B.P. :
Transsphenoid hypophysectomy for treating dogs with Cushings-disease [Dutch] Tijdschrift voor Diergeneeskunde 123:530-534, 1998. Pubmed reference: 9764462.
1997 Yamini, B., Vandenbrink, P.L., Refsal, K.R. :
Ovarian steroid cell tumor resembling luteoma associated with hyperadrenocorticism (cushings disease) in a dog Veterinary Pathology 34:57-60, 1997. Pubmed reference: 9150550.
1996 Thuroczy, J., Huszenicza, G., Magdus, M., Hargittai, T., Papp, L., Voros, K., Rudas, P. :
On the canine cushings syndrome - survey 1 - pathophysiology and symptoms of the hyperadrenocorticism - survey 2 - diagnosis and therapy of the hyperadrenocorticism [Hungarian] Magyar Allatorvosok Lapja 51:42 ff., 1996.
1995 Regnier, A., Garnier, F. :
Growth hormone responses to growth hormone-releasing hormone and clonidine in dogs with Cushing's syndrome Research in Veterinary Science 58:169-173, 1995. Pubmed reference: 7761697.
1994 Berry, C.R., Ackerman, N., Monce, K. :
Pulmonary Mineralization in Four Dogs with Cushings Syndrome Veterinary Radiology & Ultrasound 35:10-16, 1994.
Feldman, E.C., Nelson, R.W. :
Comparative aspects of Cushing's syndrome in dogs and cats Endocrinology and Metabolism Clinics of North America 23:671-691, 1994. Pubmed reference: 7805662.
Vanwijk, P.A., Rijnberk, A., Croughs, R.J.M., Wolfswinkel, J., Selman, P.J., Mol, J.A. :
Responsiveness to Corticotropin-Releasing Hormone and Vasopressin in Canine Cushings Syndrome European Journal of Endocrinology 130:410-416, 1994. Pubmed reference: 8162173.
1992 Scholten-Sloof, BE., Knol, BW., Rijnberk, A., Mol, JA., Middleton, DJ., Ubbink, GJ. :
Pituitary-dependent hyperadrenocorticism in a family of Dandie Dinmont terriers. J Endocrinol 135:535-42, 1992. Pubmed reference: 1487706.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 04 Nov 2020