OMIA:000283-9823 : Diabetes mellitus, type 1 in Sus scrofa (pig) |
In other species: chimpanzee , domestic cat , taurine cattle , domestic guinea pig
Categories: Endocrine / exocrine gland phene (incl mammary gland)
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 222100 (trait)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: unknown
Disease-related: yes
Species-specific description: Mourad et al. (2024) "describe in vitro characterization of the secretory function of pancreatic islets, derived from transgenic pigs expressing the GLP-1M3R cassette under the porcine insulin promoter (InsGLP-1M3R), and their usage to treat insulin-dependent diabetes in an immunodeficient mouse model." (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000283-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Mourad, N.I., Perota, A., Xhema, D., Duchi, R., Lagutina, I., Galli, C., Gianello, P. : |
| Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy. Proc Natl Acad Sci U S A 121:e2409138121, 2024. Pubmed reference: 39495930. DOI: 10.1073/pnas.2409138121. |
Edit History
- Created by Imke Tammen2 on 06 Nov 2024
- Changed by Imke Tammen2 on 06 Nov 2024