OMIA:000366-9615 : Fanconi syndrome in Canis lupus familiaris (dog)

In other species: domestic cat , horse , taurine cattle

Categories: Renal / urinary system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 227810 (trait) , 138160 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Key variant is published: no

Cross-species summary: Also known as Fanconi-Bickel Syndrome (FBS)

Species-specific description: Fanconi syndrome is a proximal renal tubular defect affecting the resorption of various substances filtered by the glomeruli. In addition to genetic forms, acquired proximal renal tubulopathies are also called Fanconi syndrome and have been reported in dogs to be related to excessive ingestion of jerky treats, gentamicin therapy, primary hypoparathyroidism, ethylene glycol toxicity, presumed pyelonephritis and copper storage hepatopathy.

This entry lists references to (suspected) genetic and acquired forms of the disease. Information relating to inherited Fanconi Syndrome in Basenji dogs due to a mutation in the FAN1 gene have been moved to 'OMIA:002683-9615 : Fanconi syndrome, FAN1-related in Canis lupus familiaris' [2/5/2023]

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Border Terrier (Dog) (VBO_0200194), Irish Wolfhound (Dog) (VBO_0200706), Norwegian Elkhound (Dog) (VBO_0200955).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000366-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Schaalo, S., Miklis, A., Schlüter, C., Neiger, R. :
Erworbenes transientes Fanconi-Syndrom nach Fütterung von Trockenfleisch als Leckerchen beim Hund [Acquired transient Fanconi syndrome after feeding jerky treats in dogs - A case series]. Tierarztl Prax Ausg K Kleintiere Heimtiere 49:300-308, 2021. Pubmed reference: 34425609. DOI: 10.1055/a-1514-6014.
2019 Ahn, J.O., Kim, S.M., Song, W.J., Ryu, M.O., Li, Q., Chung, J.Y., Youn, H.Y. :
Transient Fanconi Syndrome After Treatment with Firocoxib, Cefadroxil, Tramadol, and Famotidine in a Maltese. J Am Anim Hosp Assoc 55:323-327, 2019. Pubmed reference: 31525093. DOI: 10.5326/JAAHA-MS-6786.
2018 Bommer, N.X., Brownlie, S.E., Morrison, L.R., Chandler, M.L., Simpson, J.W. :
Fanconi syndrome in Irish Wolfhound siblings. J Am Anim Hosp Assoc 54:173-178, 2018. Pubmed reference: 29558216. DOI: 10.5326/JAAHA-MS-6439.
2014 Carmichael, N., Lee, J., Giger, U. :
Fanconi syndrome in dog in the UK. Vet Rec 174:357-8, 2014. Pubmed reference: 24700011. DOI: 10.1136/vr.g2554.
Major, A., Schweighauser, A., Hinden, S.E., Francey, T. :
Transient Fanconi syndrome with severe polyuria and polydipsia in a 4-year old Shih Tzu fed chicken jerky treats. Schweiz Arch Tierheilkd 156:593-8, 2014. Pubmed reference: 25497565. DOI: 10.1024/0036-7281/a000655.
2011 Hooper, A.N., Roberts, B.K. :
Fanconi syndrome in four non-basenji dogs exposed to chicken jerky treats. J Am Anim Hosp Assoc 47:e178-87, 2011. Pubmed reference: 22058368. DOI: 10.5326/JAAHA-MS-5602.
2008 Hill, T.L., Breitschwerdt, E.B., Cecere, T., Vaden, S. :
Concurrent hepatic copper toxicosis and Fanconi's syndrome in a dog. J Vet Intern Med 22:219-22, 2008. Pubmed reference: 18289313. DOI: 10.1111/j.1939-1676.2007.0040.x.
2004 Hostutler, RA., DiBartola, SP., Eaton, KA. :
Transient proximal renal tubular acidosis and Fanconi syndrome in a dog. J Am Vet Med Assoc 224:1611-4, 1605, 2004. Pubmed reference: 15154730.
Yearley, JH., Hancock, DD., Mealey, KL. :
Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome. J Am Vet Med Assoc 225:377-83, 2004. Pubmed reference: 15328712.
1996 Darrigrandhaag, R.A., Center, S.A., Randolph, J.F., Lewis, R.M., Wood, P.A. :
Congenital Fanconi syndrome associated with renal dysplasia in 2 Border Terriers Journal of Veterinary Internal Medicine 10:412-419, 1996. Pubmed reference: 8947876.
1995 Bark, H., Perk, R. :
Fanconi Syndrome associated with amoxicillin therapy in the dog Canine Practice 20:19-22, 1995.
1994 Settles, E.L., Schmidt, D. :
Fanconi syndrome in a Labrador Retriever Journal of Veterinary Internal Medicine 8:390-393, 1994. Pubmed reference: 7884724.
1993 Escolar, E., Perezalenza, D., Diaz, M., Rodriguez, A. :
Canine Fanconi syndrome. Journal of Small Animal Practice 34:567-570, 1993.
1979 Bovée, K.C., Joyce, T., Blazer-Yost, B., Goldschmidt, M.S., Segal, S. :
Characterization of renal defects in dogs with a syndrome similar to the Fanconi syndrome in man. J Am Vet Med Assoc 174:1094-9, 1979. Pubmed reference: 438041.
1978 Bovée, K.C., Joyce, T., Reynolds, R., Segal, S. :
Spontaneous Fanconi syndrome in the dog. Metabolism 27:45-52, 1978. Pubmed reference: 619225.
1970 Finco, D.R., Kurtz, H.J., Low, D.G., Perman, V. :
Familial renal disease in Norwegian Elkhound dogs Journal of the American Veterinary Medical Association 156:747-760, 1970. Pubmed reference: 5462987.

Edit History


  • Created by Frank Nicholas on 02 Apr 2011
  • Changed by Frank Nicholas on 15 Aug 2012
  • Changed by Frank Nicholas on 24 Mar 2015
  • Changed by Frank Nicholas on 24 Mar 2018
  • Changed by Imke Tammen2 on 26 Aug 2021
  • Changed by Imke Tammen2 on 02 May 2023