OMIA 000437-9685 : Haemophilia A in Felis catus

In other species: dog , horse , pig , cattle , sheep

Possibly relevant human trait(s) and/or gene(s) (MIM number): 306700

Mendelian trait/disorder: yes

Mode of inheritance: X-linked

Considered a defect: yes

Key variant known: no

Cross-species summary: Also called factor VIII deficiency. Impaired coagulability of the blood, with a consequential strong tendency to bleed, due to a deficiency of clotting factor VIII. Since the gene for this factor is located on the X chromosome, the disorder is expected to be X-linked. As with haemophilia B, this expectation has been confirmed in all species of mammal in which the disorder has been reported. In humans, there are hundreds of different mutations that give rise to haemophilia A. In domesticated animals, the disorder has been reported in a large range of species.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1990 Littlewood, J.D., Evans, R.J. :
A Combined Deficiency of Factor-VIII and Contact Activation Defect in a Family of Cats British Veterinary Journal 146:30-35, 1990. Pubmed reference: 2306600. DOI: 10.1016/0007-1935(90)90073-C.
1988 Fogh, J.M., Fogh, I.T. :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988. Pubmed reference: 3282382.
1978 Cotter, S.M., Brenner, R.M., Dodds, W.J. :
Hemophilia A in three unrelated cats. J Am Vet Med Assoc 172:166-8, 1978. Pubmed reference: 627514.

Edit History


  • Created by Frank Nicholas on 16 Jul 2005
  • Changed by Frank Nicholas on 29 Aug 2013