OMIA:000465-9823 : Hernia, umbilical in Sus scrofa (pig)

In other species: dog , domestic cat , Asiatic elephant , horse , taurine cattle , sheep , American mink

Categories: Growth / size / body region phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Cross-species summary: Protrusion of part of the intestine or other abdominal organs through the abdominal wall at the umbilicus, the protrusion being covered with skin and subcutaneous tissue.

Inheritance: Often shows familial occurrence, but convincing evidence for single-locus inheritance is lacking.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000465-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Wozniak, J., Loba, W., Iskrzak, P., Pszczola, M., Wojtczak, J., Switonski, M., Nowacka-Woszuk, J. :
A confirmed association between DNA variants in CAPN9, OSM, and ITGAM candidate genes and the risk of umbilical hernia in pigs. Anim Genet 54:307-314, 2023. Pubmed reference: 37128869. DOI: 10.1111/age.13307.
Wozniak, J., Loba, W., Wysocka, A., Dzimira, S., Przadka, P., Switonski, M., Nowacka-Woszuk, J. :
Altered transcript levels of MMP13 and VIT genes in the muscle and connective tissue of pigs with umbilical hernia. Genes (Basel) 14, 2023. Pubmed reference: 37895252. DOI: 10.3390/genes14101903.
Yang, H., Wang, L., Yin, L., Tang, Z., Wang, Z., Liu, X., Xiang, T., Yu, M., Liu, X., Li, C. :
Searching for new signals for susceptibility to umbilical hernia through genome-wide association analysis in three pig breeds. Anim Genet , 2023. Pubmed reference: 37705280. DOI: 10.1111/age.13347.
2021 Savoldi, I.R., Ibelli, A.M.G., Cantão, M.E., Peixoto, J.O., Pires, M.P., Mores, M.A.Z., Lagos, E.B., Lopes, J.S., Zanella, R., Ledur, M.C. :
A joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs. BMC Genomics 22:818, 2021. Pubmed reference: 34773987. DOI: 10.1186/s12864-021-08138-4.
2019 Li, X., Xu, P., Zhang, C., Sun, C., Li, X., Han, X., Li, M., Qiao, R. :
Genome-wide association study identifies variants in the CAPN9 gene associated with umbilical hernia in pigs. Anim Genet 50:162-165, 2019. Pubmed reference: 30746724. DOI: 10.1111/age.12760.
2018 Grindflek, E., Hansen, M.H.S., Lien, S., van Son, M. :
Genome-wide association study reveals a QTL and strong candidate genes for umbilical hernia in pigs on SSC14. BMC Genomics 19:412, 2018. Pubmed reference: 29843603. DOI: 10.1186/s12864-018-4812-9.
2016 Long, Y., Su, Y., Ai, H., Zhang, Z., Yang, B., Ruan, G., Xiao, S., Liao, X., Ren, J., Huang, L., Ding, N. :
A genome-wide association study of copy number variations with umbilical hernia in swine. Anim Genet , 2016. Pubmed reference: 27028052. DOI: 10.1111/age.12402.
2015 Liao, X.J., Lia, L., Zhang, Z.Y., Long, Y., Yang, B., Ruan, G.R., Su, Y., Ai, H.S., Zhang, W.C., Deng, W.Y., Xiao, S.J., Ren, J., Ding, N.S., Huang, L.S. :
Susceptibility loci for umbilical hernia in swine detected by genome-wide association. Genetika 51:1163-70, 2015. Pubmed reference: 27169231.
2009 Ding, NS., Mao, HR., Guo, YM., Ren, J., Xiao, SJ., Wu, GZ., Shen, HQ., Wu, LH., Ruan, GF., Brenig, B., Huang, LS. :
A genome-wide scan reveals candidate susceptibility loci for pig hernias in an intercross between White Duroc and Erhualian. J Anim Sci 87:2469-74, 2009. Pubmed reference: 19359506. DOI: 10.2527/jas.2008-1601.
1992 Berger, B., Grabherr, H., Fischerleitner, F. :
Gene frequencies and phenotypical expression of some important hereditary defects in pigs as a basis for practical progeny testing. Wiener Tierarztliche Monatsschrift 79:212-214, 1992.
Stigler, J., Distl, O., Kruff, B., Krausslich, H. :
Studies of economically important congenital anomalies of pigs. Tierarztliche Umschau 47:883-886, 1992.
1982 Ollivier, L., Sellier, P. :
Pig genetics: a review Annales de Genetique et de Selection Animale 14:481-544, 1982.
1974 Hayes, H.M. :
Congenital umbilical and inguinal hernias in cattle, horses, swine, dogs and cats: risk by breed and sex among hospital patients American Journal of Veterinary Research 35:839-842, 1974.
1962 Hamori, D. :
[Predisposition to hernia in pigs] Zuchthygiene, Fortpflanzungsstorungen und Besamung der Haustiere 6:80-84, 1962.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 23 Sep 2019
  • Changed by Imke Tammen2 on 18 Nov 2021