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OMIA:000499-10036 : Hypercholesterolaemia in Mesocricetus auratus (golden hamster)

In other species: crab-eating macaque , Rhesus monkey , dog , pig , rabbit

Categories: Homeostasis / metabolism phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 143890 (trait) , 606945 (gene)

Mendelian trait/disorder: yes

Disease-related: yes

Key variant known: no

Cross-species summary: Hypercholesterolemia; see also OMIA:001160: Hyperlipidaemia

Species-specific description: Guo et al. (2018) "generated Ldlr-ablated hamsters using CRISPR/Cas9 technology". Thus these animals are genetically-modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Ldlr low density lipoprotein receptor Mesocricetus auratus NW_024429203.1 (1975372..2000518) Ldlr Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000499-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Bai, Y., Hei, N., Gao, M., Dong, X., Li, M., Jiang, S., Zhang, L. :
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway. Toxicol Lett 384:S0378-4274(23)00222-9:30-43, 2023. Pubmed reference: 37459939. DOI: 10.1016/j.toxlet.2023.07.009.
2021 Lin, X., Ma, P., Yang, C., Wang, J., He, K., Chen, G., Huang, W., Fan, J., Xian, X., Wang, Y., Liu, G. :
Dietary-induced elevations of triglyceride-rich lipoproteins promote atherosclerosis in the low-density lipoprotein receptor knockout Syrian golden hamster. Front Cardiovasc Med 8:738060, 2021. Pubmed reference: 34796210. DOI: 10.3389/fcvm.2021.738060.
2019 Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X., Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G., Xian, X. :
Dietary cholesterol is highly associated with severity of hyperlipidemia and atherosclerotic lesions in heterozygous LDLR-deficient hamsters. Int J Mol Sci 20:3515, 2019. Pubmed reference: 31323736. DOI: 10.3390/ijms20143515.
2018 Guo, X., Gao, M., Wang, Y., Lin, X., Yang, L., Cong, N., An, X., Wang, F., Qu, K., Yu, L., Wang, Y., Wang, J., Zhu, H., Xian, X., Liu, G. :
LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis. EBioMedicine 27:214-224, 2018. Pubmed reference: 29289533. DOI: 10.1016/j.ebiom.2017.12.013.

Edit History


  • Created by Frank Nicholas on 21 Sep 2019
  • Changed by Frank Nicholas on 21 Sep 2019
  • Changed by Imke Tammen2 on 10 Dec 2023