OMIA 000499-9986 : Hypercholesterolaemia in Oryctolagus cuniculus

In other species: pig , dog

Possibly relevant human trait(s) and/or gene(s) (MIM number): 143890

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific name: Watanabe heritable hyperlipidemia

Species-specific description: In addition to naturally-occurring variants for this trait, variants have been created artificially: Genetically-modifed organism; GMO.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Loke, S.Y., Wong, P.T., Ong, W.Y. :
Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochem Int :, 2016. Pubmed reference: 27890723. DOI: 10.1016/j.neuint.2016.11.010.
2006 Hyafil, F., Laissy, J.P., Mazighi, M., Tchétché, D., Louedec, L., Adle-Biassette, H., Chillon, S., Henin, D., Jacob, M.P., Letourneur, D., Feldman, L.J. :
Ferumoxtran-10-enhanced MRI of the hypercholesterolemic rabbit aorta: relationship between signal loss and macrophage infiltration. Arterioscler Thromb Vasc Biol 26:176-81, 2006. Pubmed reference: 16269663. DOI: 10.1161/01.ATV.0000194098.82677.57.
2005 Finné Nielsen, I.L., Elbøl Rasmussen, S., Mortensen, A., Ravn-Haren, G., Ma, H.P., Knuthsen, P., Hansen, B.F., McPhail, D., Freese, R., Breinholt, V., Frandsen, H., Dragsted, L.O. :
Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits. Mol Nutr Food Res 49:301-8, 2005. Pubmed reference: 15759306. DOI: 10.1002/mnfr.200400097.
Koike, T., Liang, J., Wang, X., Ichikawa, T., Shiomi, M., Sun, H., Watanabe, T., Liu, G., Fan, J. :
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc Res 65:524-34, 2005. Pubmed reference: 15639492. DOI: 10.1016/j.cardiores.2004.10.022.
Kurosawa, T., Itoh, F., Nozaki, A., Nakano, Y., Katsuda, S., Osakabe, N., Tsubone, H., Kondo, K., Itakura, H. :
Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. Atherosclerosis 179:237-46, 2005. Pubmed reference: 15777537. DOI: 10.1016/j.atherosclerosis.2004.12.003.
Shukla, N., Jones, R., Persad, R., Angelini, GD., Jeremy, JY. :
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. Eur J Pharmacol 517:224-31, 2005. Pubmed reference: 15963496. DOI: 10.1016/j.ejphar.2005.05.012.
2004 Allegri, G., Ragazzi, E., Costa, CV., Caparrotta, L., Biasiolo, M., Comai, S., Bertazzo, A. :
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits. Clin Chim Acta 350:41-9, 2004. Pubmed reference: 15530458. DOI: 10.1016/j.cccn.2004.06.026.
Ammar, EM., Said, SA., Hassan, MS. :
Enhanced vasoconstriction and reduced vasorelaxation induced by testosterone and nandrolone in hypercholesterolemic rabbits. Pharmacol Res 50:253-9, 2004. Pubmed reference: 15225667. DOI: 10.1016/j.phrs.2004.03.010.
Ander, BP., Weber, AR., Rampersad, PP., Gilchrist, JS., Pierce, GN., Lukas, A. :
Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. J Nutr 134:3250-6, 2004. Pubmed reference: 15570021.
Hänni, M., Edvardsson, H., Wågberg, M., Pettersson, K., Smedby, O. :
Quantification of atherosclerosis with MRI and image processing in spontaneously hyperlipidemic rabbits. J Cardiovasc Magn Reson 6:675-84, 2004. Pubmed reference: 15347132.
Kankkonen, H.M., Vähäkangas, E., Marr, R.A., Pakkanen, T., Laurema, A., Leppänen, P., Jalkanen, J., Verma, I.M., Ylä-Herttuala, S. :
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther 9:548-56, 2004. Pubmed reference: 15093185. DOI: 10.1016/j.ymthe.2004.01.015.
Li, W., Hellsten, A., Jacobsson, LS., Blomqvist, HM., Olsson, AG., Yuan, XM. :
Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. J Mol Cell Cardiol 37:969-78, 2004. Pubmed reference: 15522274. DOI: 10.1016/j.yjmcc.2004.07.009.
2003 Eto, Y., Shimokawa, H., Tanaka, E., Morishige, K., Fuchigami, M., Ishiwata, Y., Matsushima, K., Takeshita, A. :
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits Journal of Cardiovascular Pharmacology 41:171-7, 2003. Pubmed reference: 12548076.
Mehta, K., Balaraman, R., Amin, A.H., Bafna, P.A., Gulati, O.D. :
Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits Journal of Ethnopharmacology 86:191-5, 2003. Pubmed reference: 12738086.
Tanaka, E., Shimokawa, H., Kamiuneten, H., Eto, Y., Matsumoto, Y., Morishige, K., Koike, G., Yoshinaga, M., Egashira, K., Tokunaga, O., Shiomi, M., Takeshita, A. :
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis Arteriosclerosis, Thrombosis & Vascular Biology 23:244-50, 2003.
2002 Cejna, M., Breuss, J.M., Bergmeister, H., de, Martin, R., Xu, Z.Y., Grgurin, M., Losert, U., Plenk, H., Binder, B.R., Lammer, J. :
Inhibition of neointimal formation after stent placement with adenovirus-mediated gene transfer of I kappa B alpha in the hypercholesterolemic rabbit model: Initial results Radiology 223:702-708, 2002. Pubmed reference: 12034938.
Dalsgaard, T., Larsen, C.R., Mortensen, A., Larsen, J.J., Ottesen, B. :
New animal model for the study of postmenopausal coronary and cerebral artery function: the Watanabe heritable hyperlipidemic rabbit fed on a diet avoiding phytoestrogens Climacteric 5:178-189, 2002. Pubmed reference: 12051114.
McCabe, P.M., Gonzales, J.A., Zaias, J., Szeto, A., Kumar, M., Herron, A.J., Schneiderman, N. :
Social environment influences the progression of atherosclerosis in the watanabe heritable hyperlipidemic rabbit Circulation 105:354-359, 2002. Pubmed reference: 11804992.
1999 Le, Tourneau, T., Van, Belle, E., Corseaux, D., Vallet, B., Lebuffe, G., Dupuis, B., Lablanche, J.M., McFadden, E., Bauters, C., Bertrand, M.E. :
Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: Effects on neointimal hyperplasia and vascular remodeling Journal of the American College of Cardiology 33:876-882, 1999. Pubmed reference: 10080493.
1998 Aliev, G., Bodin, P., Burnstock, G. :
Free radical generators cause changes in endothelial and inducible nitric oxide synthases and ENDOTHELIN-1 immunoreactivity in endothelial cells from hyperlipidemic rabbits Molecular Genetics & Metabolism 63:191-197, 1998.
Corjay, M.H., Kearney, M.A., Munzer, D.A., Diamond, S.M., Stoltenborg, J.K. :
Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in watanabe heritable hyperlipidemic rabbit and human Laboratory Investigation 78:847-858, 1998. Pubmed reference: 9690562.
Corseaux, D., Letourneau, T., Six, I., Ezekowitz, M.D., Mcfadden, E.P., Meurice, T., Asseman, P., Bauters, C., Jude, B. :
Enhanced monocyte tissue factor response after experimental balloon angioplasty in hypercholesterolemic rabbit - inhibition with dietary l-arginine Circulation 98:1776-1782, 1998. Pubmed reference: 9788833.
Handy, D.E., Johns, C., Bresnahan, M.R., Tavares, A., Bursztyn, M., Gavras, H. :
Expression of ALPHA(2)-ADRENERGIC receptors in normal and atherosclerotic rabbit aorta Hypertension 32:311-317, 1998. Pubmed reference: 9719060.
Hiltunen, T.P., Luoma, J.S., Nikkari, T., Ylaherttuala, S. :
Expression of ldl receptor, vldl receptor, ldl receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions - marked induction of scavenger receptor and vldl receptor expression during lesion development Circulation 97:1079-1086, 1998. Pubmed reference: 9531255.
Jackson, M., Ramjiawan, B., Hewko, M., Mantsch, H.H. :
Infrared microscopic functional group mapping and spectral clustering analysis of hypercholesterolemic rabbit liver Cellular & Molecular Biology 44:89-98, 1998.
Kagota, S., Yamaguchi, Y., Shinozuka, K., Kunitomo, M. :
Mechanisms of impairment of endothelium-dependent relaxation to acetylcholine in Watanabe heritable hyperlipidaemic rabbit aortas Clinical & Experimental Pharmacology & Physiology 25:104-109, 1998.
Naka, Y., Yoshino, G., Hirano, T., Murata, Y., Maeda, E., Kazumi, T., Kasuga, M. :
Triglyceride metabolism in heterozygote of watanabe heritable hyperlipidemic rabbit Atherosclerosis 136:325-332, 1998. Pubmed reference: 9543104.
Wasan, K.M., Kennedy, A.L., Cassidy, S.M., Ramaswamy, M., Holtorf, L., Chou, J.W.L., Pritchard, P.H. :
Pharmacokinetics, distribution in serum lipoproteins and tissues, and renal toxicities of amphotericin B and amphotericin B lipid complex in a hypercholesterolemic rabbit model: Single-dose studies Antimicrobial Agents & Chemotherapy 42:3146-3152, 1998.
1997 Dabbagh, A.J., Shwaery, G.T., Keaney, J.F., Frei, B. :
Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit Arteriosclerosis Thrombosis & Vascular Biology 17:2638-2645, 1997.
Meurice, T., Bauters, C., Vallet, B., Corseaux, D., Vanbelle, E., Hamon, M., Dupuis, B., Lablanche, J.M., Bertrand, M.E. :
Bfgf restores endothelium-dependent responses of hypercholesterolemic rabbit thoracic aorta American Journal of Physiology - Heart & Circulatory Physiology 41:H 613-H 617, 1997.
Nordestgaard, B.G., Agerholm-Larsen, B., Mortensen, A., Hansen, B.F., Hansen, J.F., Ibsen, P., Kjeldsen, K. :
Intermediate density lipoprotein cholesterol as the best lipoprotein predictor of atherosclerosis severity in the watanabe heritable hyperlipidemic rabbit 132:119-122, 1997. Pubmed reference: 9247367.
Origuchi, N., Shigematsu, H., Muto, T. :
Anplag, a selective 5-HT2 receptor antagonist, reduces stenosis induced by balloon injury in the hypercholesterolaemic rabbit International Angiology 16:204-209, 1997. Pubmed reference: 9405017.
Takagi, M., Ueda, M., Becker, A.E., Takeuchi, K., Takeda, T. :
The Watanabe heritable hyperlipidemic rabbit as a suitable experimental model to study differences in tissue response between intimal and medial injury after balloon angioplasty Arteriosclerosis Thrombosis & Vascular Biology 17:3611-3619, 1997.
1996 Buyssens, N., Kockx, M., Vandenbossche, R., Jacob, W., Herman, A. :
Destruction of lacis cells of the juxtaglomerular apparatus in the hypercholesterolemic rabbit Pathology, Research & Practice 192:508-512, 1996.
Jeremy, R.W., Mccarron, H., Sullivan, D. :
Effects of dietary l-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit - response according to treatment duration, anatomic site, and sex Circulation 94:498-506, 1996. Pubmed reference: 8759095.
Nakazato, K., Ishibashi, T., Shindo, J., Shiomi, M., Maruyama, Y. :
Expression of very low density lipoprotein receptor mrna in rabbit atherosclerotic lesions American Journal of Pathology 149:1831-1838, 1996. Pubmed reference: 8952520.
Pfister, S.L., Campbell, W.B. :
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas Journal of Cardiovascular Pharmacology 28:784-791, 1996. Pubmed reference: 8961076.
White, C.R., Darleyusmar, V., Berrington, W.R., Mcadams, M., Gore, J.Z., Thompson, J.A., Parks, D.A., Tarpey, M.M., Freeman, B.A. :
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits Proceedings of the National Academy of Sciences of the United States of America 93:8745-8749, 1996. Pubmed reference: 8710942.
1995 Back, M.R., Carew, T.E., Schmidschoenbein, G.W. :
Deposition pattern of monocytes and fatty streak development in hypercholesterolemic rabbits Atherosclerosis 116:103-115, 1995. Pubmed reference: 7488325.
Braesen, J.H., Beisiegel, U., Niendorf, A. :
Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits Virchows Archiv - an International Journal of Pathology 426:179-188, 1995. Pubmed reference: 7757289.
Chobanian, A.V., Hope, S., Brecher, P. :
Dissociation between the antiatherosclerotic effect of trandolapril and suppression of serum and aortic angiotensin- converting enzyme activity in the Watanabe heritable hyperlipidemic rabbit Hypertension 25:1306-1310, 1995. Pubmed reference: 7768578.
Giuriato, L., Chiavegato, A., Pauletto, P., Sartore, S. :
Correlation between the presence of an immature smooth muscle cell population in tunica media and the development of atherosclerotic lesion. A study on different-sized rabbit arteries from cholesterol-fed and Watanabe heritable hyperlipemic rabbits Atherosclerosis 116:77-92, 1995. Pubmed reference: 7488335.
Hussain, M.M., Innerarity, T.L., Brecht, W.J., Mahley, R.W. :
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits - Saturation of the sequestration step of the remnant clearance pathway Journal of Biological Chemistry 270:8578-8587, 1995. Pubmed reference: 7721759.
Kang, S.Y., Kim, S.H., Schini, V.B., Kim, N.D. :
Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit General Pharmacology 26:483-487, 1995. Pubmed reference: 7789720.
Li, J., Fang, B.L., Eisensmith, R.C., Li, X.H.C., Nasonkin, I., Linlee, Y.C., Mims, M.P., Hughes, A., Montgomery, C.D., Roberts, J.D., Parker, T.S., Levine, D.M., Woo, S.L.C. :
In vivo gene therapy for hyperlipidemia: Phenotypic correction in watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene Journal of Clinical Investigation 95:768-773, 1995. Pubmed reference: 7860759. DOI: 10.1172/JCI117725.
Najibi, S., Cohen, R.A. :
Enhanced role of k+ channels in relaxations of hypercholesterolemic rabbit carotid artery to NO American Journal of Physiology - Heart & Circulatory Physiology 38:H 805-H 811, 1995.
Nordestgaard, B.G., Wootton, R., Lewis, B. :
Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo - Molecular size as a determinant of fractional loss from the intima inner media Arteriosclerosis Thrombosis and Vascular Biology 15:534-542, 1995.
Ragazzi, E., Chinellato, A., Pandolfo, L., Froldi, G., Caparrotta, L., Aliev, G., Prosdocimi, M., Fassina, G. :
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits Journal of Cardiovascular Pharmacology 26:119-126, 1995. Pubmed reference: 7564351.
Sohma, Y., Sasano, H., Shiga, R., Saeki, S., Suzuki, T., Nagura, H., Nose, M., Yamamoto, T. :
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Proceedings of the National Academy of Sciences of the United States of America 92:4937-4941, 1995. Pubmed reference: 7761428.
Stewartlee, A.L., Ferns, G.A., Anggard, E.E. :
Differences in onset of impaired endothelial responses and in effects of vitamin E in the hypercholesterolemic rabbit carotid and renal arteries Journal of Cardiovascular Pharmacology 25:906-913, 1995. Pubmed reference: 7564335.
Tanaka, M., Otani, H., Yokode, M., Kita, T. :
Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia Atherosclerosis 114:73-82, 1995. Pubmed reference: 7605378.
Wu, C.C., Chang, S.W., Chen, M.S., Lee, Y.T. :
Early change of vascular permeability in hypercholesterolemic rabbits Arteriosclerosis Thrombosis and Vascular Biology 15:529-533, 1995.
Xu, G.R., Salen, G., Shefer, S., Ness, G.C., Nguyen, L.B., Parker, T.S., Chen, T.S., Zhao, Z.H., Donnelly, T.M., Tint, G.S. :
Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits Journal of Clinical Investigation 95:1497-1504, 1995. Pubmed reference: 7706454. DOI: 10.1172/JCI117821.
1994 Daugherty, A., Rateri, D.L. :
Presence of LDL receptor-related protein alpha(2)- macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits Arteriosclerosis and Thrombosis 14:2017-2024, 1994. Pubmed reference: 7526898.
Kinter, M., Robinson, C.S., Grimminger, L.C., Gillies, P.J., Shimshick, E.J., Ayers, C. :
Whole Blood and Plasma Concentrations of 4-Hydroxy-2-Nonenal in Watanabe Heritable Hyperlipidemic Versus New Zealand White Rabbits Biochemical and Biophysical Research Communications 199:671-675, 1994. Pubmed reference: 8135808. DOI: 10.1006/bbrc.1994.1280.
Kozarsky, K.F., Mckinley, D.R., Austin, L.L., Raper, S.E., Stratfordperricaudet, L.D., Wilson, J.M. :
In Vivo Correction of Low Density Lipoprotein Receptor Deficiency in the Watanabe Heritable Hyperlipidemic Rabbit with Recombinant Adenoviruses Journal of Biological Chemistry 269:13695-13702, 1994. Pubmed reference: 8175805.
Mamo, J.C.L., Bowler, A., Redgrave, T.G., Elsegood, C.L. :
Clearance of chylomicron-like lipid emulsions is increased in normal rabbits but not in heterozygous Watanabe heritable hyperlipidaemic rabbits following treatment with cholestyramine or pravastatin Clinical and Experimental Pharmacology & Physiology 21:687-694, 1994. Pubmed reference: 7820948.
Shiomi, M., Shiraishi, M., Yata, T., Ito, T. :
Effect of fluvastatin sodium on secretion of very low density lipoprotein and serum cholesterol levels - In vivo study using low density lipoprotein receptor deficient Watanabe heritable hyperlipidemic rabbits Arzneimittel - Forschung/Drug Research 44-2:1154-1156, 1994.
Sohma, Y., Suzuki, T., Sasano, H., Nagura, H., Nose, M., Yamamoto, T. :
Expression of mRNA for matrix gamma-carboxyglutamic acid protein during progression of atherosclerosis in aortae of Watanabe heritable hyperlipidemic rabbits Journal of Biochemistry 116:747-751, 1994. Pubmed reference: 7883748.
Sohma, Y., Suzuki, T., Sasano, H., Nagura, H., Nose, M., Yamamoto, T. :
Increased mRNA for CD63 antigen in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Cell Structure and Function 19:219-225, 1994. Pubmed reference: 7820873.
1993 Esper, E., Chan, E.K., Buchwald, H. :
Natural History of Atherosclerosis and Hyperlipidemia in Heterozygous WHHL (WHHL-Hh) Rabbits .1. The Effects of Aging and Gender on Plasma Lipids and Lipoproteins Journal of Laboratory and Clinical Medicine 121:97-102, 1993. Pubmed reference: 8426086.
Esper, E., Runge, W.J., Gunther, R., Buchwald, H. :
Natural History of Atherosclerosis and Hyperlipidemia in Heterozygous WHHL (WHHL-Hh) Rabbits .2. Morphologic Evaluation of Spontaneously Occurring Aortic and Coronary Lesions Journal of Laboratory and Clinical Medicine 121:103-110, 1993. Pubmed reference: 8426070.
Liu, R., Saku, K., Kostner, G.M., Hirata, K., Zhang, B., Shiomi, M., Arakawa, K. :
Invivo Kinetics of Lipoprotein(a) in Homozygous Watanabe Heritable Hyperlipidaemic Rabbits European Journal of Clinical Investigation 23:561-565, 1993. Pubmed reference: 8243527.
Pease, L.J., Robinson, C.S., Gillies, P.J., Bozarth, J.M., Reilly, T.M., Mousa, S.A. :
Increased Platelet GPIIb/IIIa Receptor Sensitivity in Watanabe Heritable Hyperlipidemic Rabbits Biochemical Archives 9:311-320, 1993.
Tagawa, H., Tomoike, H., Mitsuoka, W., Satoh, S., Kuga, T., Shimokawa, H., Nakamura, M., Takeshita, A. :
Hyperreactivity of Aortic Smooth Muscle to Serotonin Is Related to the Presence of Atheroma in Watanabe Heritable Hyperlipidaemic Rabbits Cardiovascular Research 27:2164-2169, 1993. Pubmed reference: 8313424.
Wanibuchi, H., Dingemans, K.P., Becker, A.E., Ueda, M., Naruko, T., Tanizawa, S., Nakamura, K. :
Is the Watanabe Heritable Hyperlipidemic Rabbit a Suitable Experimental Model for Percutaneous Transluminal Coronary Angioplasty in Humans? - A Light Microscopic, Immunohistochemical and Ultrastructural Study Journal of the American College of Cardiology 21:1490-1496, 1993. Pubmed reference: 8473661.
Westenend, P.J., Kroon, A.A., Stalenhoef, A.F.H., Assmann, K.H.J. :
Absence of Glomerulosclerosis in Watanabe Heritable Hyperlipidemic Rabbits Nephron 64:150-151, 1993. Pubmed reference: 8502322.
Willingham, A.K., Bolanos, C., Bohannan, E., Cenedella, R.J. :
The Effects of High Levels of Vitamin-E on the Progression of Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit Journal of Nutritional Biochemistry 4:651-654, 1993.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 29 Sep 2016