OMIA:000499-9986 : Hypercholesterolaemia in Oryctolagus cuniculus (rabbit)

In other species: crab-eating macaque , Rhesus monkey , dog , pig , golden hamster

Categories: Homeostasis / metabolism phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 143890 (trait) , 606945 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: Hypercholesterolemia; see also OMIA:001160: Hyperlipidaemia

Species-specific name: Watanabe heritable hyperlipidemia

Species-specific description: In addition to naturally-occurring variants for this trait, variants have been created artificially: Genetically-modifed organism; GMO.

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000499-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Shiomi, M. :
The history of the WHHL rabbit, an animal model of familial hypercholesterolemia (I) - contribution to the elucidation of the pathophysiology of human hypercholesterolemia and coronary heart disease. J Atheroscler Thromb 27:105-118, 2020. Pubmed reference: 31748469. DOI: 10.5551/jat.RV17038-1.
Shiomi, M. :
The history of the WHHL rabbit, an animal model of familial hypercholesterolemia (II) - Contribution to the development and validation of the therapeutics for hypercholesterolemia and atherosclerosis. J Atheroscler Thromb 27:119-131, 2020. Pubmed reference: 31748470. DOI: 10.5551/jat.RV17038-2.
2018 Tranchart, H., Gaillard, M., Diop, P.S., Goulinet, S., Lainas, P., Dagher, I. :
Transplantation of genetically modified hepatocytes after liver preconditioning in Watanabe heritable hyperlipidemic rabbit. J Surg Res 224:23-32, 2018. Pubmed reference: 29506845. DOI: 10.1016/j.jss.2017.11.060.
2016 Koike, T., Tamura, S., Yu, Y., Kuniyoshi, N., Shiomi, M. :
High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris-like symptoms due to coronary spasm in WHHLMI rabbits. Exp Anim 65:419-426, 2016. Pubmed reference: 27301847. DOI: 10.1538/expanim.16-0035.
Loke, S.Y., Wong, P.T., Ong, W.Y. :
Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension. Neurochem Int , 2016. Pubmed reference: 27890723. DOI: 10.1016/j.neuint.2016.11.010.
2006 Hyafil, F., Laissy, J.P., Mazighi, M., Tchétché, D., Louedec, L., Adle-Biassette, H., Chillon, S., Henin, D., Jacob, M.P., Letourneur, D., Feldman, L.J. :
Ferumoxtran-10-enhanced MRI of the hypercholesterolemic rabbit aorta: relationship between signal loss and macrophage infiltration. Arterioscler Thromb Vasc Biol 26:176-81, 2006. Pubmed reference: 16269663. DOI: 10.1161/01.ATV.0000194098.82677.57.
2005 Finné Nielsen, I.L., Elbøl Rasmussen, S., Mortensen, A., Ravn-Haren, G., Ma, H.P., Knuthsen, P., Hansen, B.F., McPhail, D., Freese, R., Breinholt, V., Frandsen, H., Dragsted, L.O. :
Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits. Mol Nutr Food Res 49:301-8, 2005. Pubmed reference: 15759306. DOI: 10.1002/mnfr.200400097.
Koike, T., Liang, J., Wang, X., Ichikawa, T., Shiomi, M., Sun, H., Watanabe, T., Liu, G., Fan, J. :
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc Res 65:524-34, 2005. Pubmed reference: 15639492. DOI: 10.1016/j.cardiores.2004.10.022.
Kurosawa, T., Itoh, F., Nozaki, A., Nakano, Y., Katsuda, S., Osakabe, N., Tsubone, H., Kondo, K., Itakura, H. :
Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. Atherosclerosis 179:237-46, 2005. Pubmed reference: 15777537. DOI: 10.1016/j.atherosclerosis.2004.12.003.
Shukla, N., Jones, R., Persad, R., Angelini, GD., Jeremy, JY. :
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits. Eur J Pharmacol 517:224-31, 2005. Pubmed reference: 15963496. DOI: 10.1016/j.ejphar.2005.05.012.
2004 Allegri, G., Ragazzi, E., Costa, CV., Caparrotta, L., Biasiolo, M., Comai, S., Bertazzo, A. :
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits. Clin Chim Acta 350:41-9, 2004. Pubmed reference: 15530458. DOI: 10.1016/j.cccn.2004.06.026.
Ammar, EM., Said, SA., Hassan, MS. :
Enhanced vasoconstriction and reduced vasorelaxation induced by testosterone and nandrolone in hypercholesterolemic rabbits. Pharmacol Res 50:253-9, 2004. Pubmed reference: 15225667. DOI: 10.1016/j.phrs.2004.03.010.
Ander, BP., Weber, AR., Rampersad, PP., Gilchrist, JS., Pierce, GN., Lukas, A. :
Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. J Nutr 134:3250-6, 2004. Pubmed reference: 15570021.
Hänni, M., Edvardsson, H., Wågberg, M., Pettersson, K., Smedby, O. :
Quantification of atherosclerosis with MRI and image processing in spontaneously hyperlipidemic rabbits. J Cardiovasc Magn Reson 6:675-84, 2004. Pubmed reference: 15347132.
Kankkonen, H.M., Vähäkangas, E., Marr, R.A., Pakkanen, T., Laurema, A., Leppänen, P., Jalkanen, J., Verma, I.M., Ylä-Herttuala, S. :
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Mol Ther 9:548-56, 2004. Pubmed reference: 15093185. DOI: 10.1016/j.ymthe.2004.01.015.
Li, W., Hellsten, A., Jacobsson, LS., Blomqvist, HM., Olsson, AG., Yuan, XM. :
Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. J Mol Cell Cardiol 37:969-78, 2004. Pubmed reference: 15522274. DOI: 10.1016/j.yjmcc.2004.07.009.
2003 Eto, Y., Shimokawa, H., Tanaka, E., Morishige, K., Fuchigami, M., Ishiwata, Y., Matsushima, K., Takeshita, A. :
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits Journal of Cardiovascular Pharmacology 41:171-7, 2003. Pubmed reference: 12548076.
Mehta, K., Balaraman, R., Amin, A.H., Bafna, P.A., Gulati, O.D. :
Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits Journal of Ethnopharmacology 86:191-5, 2003. Pubmed reference: 12738086.
Tanaka, E., Shimokawa, H., Kamiuneten, H., Eto, Y., Matsumoto, Y., Morishige, K., Koike, G., Yoshinaga, M., Egashira, K., Tokunaga, O., Shiomi, M., Takeshita, A. :
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis Arteriosclerosis, Thrombosis & Vascular Biology 23:244-50, 2003.
2002 Cejna, M., Breuss, J.M., Bergmeister, H., de, Martin, R., Xu, Z.Y., Grgurin, M., Losert, U., Plenk, H., Binder, B.R., Lammer, J. :
Inhibition of neointimal formation after stent placement with adenovirus-mediated gene transfer of I kappa B alpha in the hypercholesterolemic rabbit model: Initial results Radiology 223:702-708, 2002. Pubmed reference: 12034938.
Dalsgaard, T., Larsen, C.R., Mortensen, A., Larsen, J.J., Ottesen, B. :
New animal model for the study of postmenopausal coronary and cerebral artery function: the Watanabe heritable hyperlipidemic rabbit fed on a diet avoiding phytoestrogens Climacteric 5:178-189, 2002. Pubmed reference: 12051114.
McCabe, P.M., Gonzales, J.A., Zaias, J., Szeto, A., Kumar, M., Herron, A.J., Schneiderman, N. :
Social environment influences the progression of atherosclerosis in the watanabe heritable hyperlipidemic rabbit Circulation 105:354-359, 2002. Pubmed reference: 11804992.
1999 Le, Tourneau, T., Van, Belle, E., Corseaux, D., Vallet, B., Lebuffe, G., Dupuis, B., Lablanche, J.M., McFadden, E., Bauters, C., Bertrand, M.E. :
Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: Effects on neointimal hyperplasia and vascular remodeling Journal of the American College of Cardiology 33:876-882, 1999. Pubmed reference: 10080493.
1998 Aliev, G., Bodin, P., Burnstock, G. :
Free radical generators cause changes in endothelial and inducible nitric oxide synthases and ENDOTHELIN-1 immunoreactivity in endothelial cells from hyperlipidemic rabbits Molecular Genetics & Metabolism 63:191-197, 1998.
Corjay, M.H., Kearney, M.A., Munzer, D.A., Diamond, S.M., Stoltenborg, J.K. :
Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in watanabe heritable hyperlipidemic rabbit and human Laboratory Investigation 78:847-858, 1998. Pubmed reference: 9690562.
Corseaux, D., Letourneau, T., Six, I., Ezekowitz, M.D., Mcfadden, E.P., Meurice, T., Asseman, P., Bauters, C., Jude, B. :
Enhanced monocyte tissue factor response after experimental balloon angioplasty in hypercholesterolemic rabbit - inhibition with dietary l-arginine Circulation 98:1776-1782, 1998. Pubmed reference: 9788833.
Handy, D.E., Johns, C., Bresnahan, M.R., Tavares, A., Bursztyn, M., Gavras, H. :
Expression of ALPHA(2)-ADRENERGIC receptors in normal and atherosclerotic rabbit aorta Hypertension 32:311-317, 1998. Pubmed reference: 9719060.
Hiltunen, T.P., Luoma, J.S., Nikkari, T., Ylaherttuala, S. :
Expression of ldl receptor, vldl receptor, ldl receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions - marked induction of scavenger receptor and vldl receptor expression during lesion development Circulation 97:1079-1086, 1998. Pubmed reference: 9531255.
Jackson, M., Ramjiawan, B., Hewko, M., Mantsch, H.H. :
Infrared microscopic functional group mapping and spectral clustering analysis of hypercholesterolemic rabbit liver Cellular & Molecular Biology 44:89-98, 1998.
Kagota, S., Yamaguchi, Y., Shinozuka, K., Kunitomo, M. :
Mechanisms of impairment of endothelium-dependent relaxation to acetylcholine in Watanabe heritable hyperlipidaemic rabbit aortas Clinical & Experimental Pharmacology & Physiology 25:104-109, 1998.
Naka, Y., Yoshino, G., Hirano, T., Murata, Y., Maeda, E., Kazumi, T., Kasuga, M. :
Triglyceride metabolism in heterozygote of watanabe heritable hyperlipidemic rabbit Atherosclerosis 136:325-332, 1998. Pubmed reference: 9543104.
Wasan, K.M., Kennedy, A.L., Cassidy, S.M., Ramaswamy, M., Holtorf, L., Chou, J.W.L., Pritchard, P.H. :
Pharmacokinetics, distribution in serum lipoproteins and tissues, and renal toxicities of amphotericin B and amphotericin B lipid complex in a hypercholesterolemic rabbit model: Single-dose studies Antimicrobial Agents & Chemotherapy 42:3146-3152, 1998.
1997 Dabbagh, A.J., Shwaery, G.T., Keaney, J.F., Frei, B. :
Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit Arteriosclerosis Thrombosis & Vascular Biology 17:2638-2645, 1997.
Meurice, T., Bauters, C., Vallet, B., Corseaux, D., Vanbelle, E., Hamon, M., Dupuis, B., Lablanche, J.M., Bertrand, M.E. :
Bfgf restores endothelium-dependent responses of hypercholesterolemic rabbit thoracic aorta American Journal of Physiology - Heart & Circulatory Physiology 41:H 613-H 617, 1997.
Nordestgaard, B.G., Agerholm-Larsen, B., Mortensen, A., Hansen, B.F., Hansen, J.F., Ibsen, P., Kjeldsen, K. :
Intermediate density lipoprotein cholesterol as the best lipoprotein predictor of atherosclerosis severity in the watanabe heritable hyperlipidemic rabbit 132:119-122, 1997. Pubmed reference: 9247367.
Origuchi, N., Shigematsu, H., Muto, T. :
Anplag, a selective 5-HT2 receptor antagonist, reduces stenosis induced by balloon injury in the hypercholesterolaemic rabbit International Angiology 16:204-209, 1997. Pubmed reference: 9405017.
Takagi, M., Ueda, M., Becker, A.E., Takeuchi, K., Takeda, T. :
The Watanabe heritable hyperlipidemic rabbit as a suitable experimental model to study differences in tissue response between intimal and medial injury after balloon angioplasty Arteriosclerosis Thrombosis & Vascular Biology 17:3611-3619, 1997.
1996 Buyssens, N., Kockx, M., Vandenbossche, R., Jacob, W., Herman, A. :
Destruction of lacis cells of the juxtaglomerular apparatus in the hypercholesterolemic rabbit Pathology, Research & Practice 192:508-512, 1996.
Jeremy, R.W., Mccarron, H., Sullivan, D. :
Effects of dietary l-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit - response according to treatment duration, anatomic site, and sex Circulation 94:498-506, 1996. Pubmed reference: 8759095.
Nakazato, K., Ishibashi, T., Shindo, J., Shiomi, M., Maruyama, Y. :
Expression of very low density lipoprotein receptor mrna in rabbit atherosclerotic lesions American Journal of Pathology 149:1831-1838, 1996. Pubmed reference: 8952520.
Pfister, S.L., Campbell, W.B. :
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas Journal of Cardiovascular Pharmacology 28:784-791, 1996. Pubmed reference: 8961076.
White, C.R., Darleyusmar, V., Berrington, W.R., Mcadams, M., Gore, J.Z., Thompson, J.A., Parks, D.A., Tarpey, M.M., Freeman, B.A. :
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits Proceedings of the National Academy of Sciences of the United States of America 93:8745-8749, 1996. Pubmed reference: 8710942.
1995 Back, M.R., Carew, T.E., Schmidschoenbein, G.W. :
Deposition pattern of monocytes and fatty streak development in hypercholesterolemic rabbits Atherosclerosis 116:103-115, 1995. Pubmed reference: 7488325.
Braesen, J.H., Beisiegel, U., Niendorf, A. :
Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits Virchows Archiv - an International Journal of Pathology 426:179-188, 1995. Pubmed reference: 7757289.
Chobanian, A.V., Hope, S., Brecher, P. :
Dissociation between the antiatherosclerotic effect of trandolapril and suppression of serum and aortic angiotensin- converting enzyme activity in the Watanabe heritable hyperlipidemic rabbit Hypertension 25:1306-1310, 1995. Pubmed reference: 7768578.
Giuriato, L., Chiavegato, A., Pauletto, P., Sartore, S. :
Correlation between the presence of an immature smooth muscle cell population in tunica media and the development of atherosclerotic lesion. A study on different-sized rabbit arteries from cholesterol-fed and Watanabe heritable hyperlipemic rabbits Atherosclerosis 116:77-92, 1995. Pubmed reference: 7488335.
Hussain, M.M., Innerarity, T.L., Brecht, W.J., Mahley, R.W. :
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits - Saturation of the sequestration step of the remnant clearance pathway Journal of Biological Chemistry 270:8578-8587, 1995. Pubmed reference: 7721759.
Kang, S.Y., Kim, S.H., Schini, V.B., Kim, N.D. :
Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit General Pharmacology 26:483-487, 1995. Pubmed reference: 7789720.
Li, J., Fang, B.L., Eisensmith, R.C., Li, X.H.C., Nasonkin, I., Linlee, Y.C., Mims, M.P., Hughes, A., Montgomery, C.D., Roberts, J.D., Parker, T.S., Levine, D.M., Woo, S.L.C. :
In vivo gene therapy for hyperlipidemia: Phenotypic correction in watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene Journal of Clinical Investigation 95:768-773, 1995. Pubmed reference: 7860759. DOI: 10.1172/JCI117725.
Najibi, S., Cohen, R.A. :
Enhanced role of k+ channels in relaxations of hypercholesterolemic rabbit carotid artery to NO American Journal of Physiology - Heart & Circulatory Physiology 38:H 805-H 811, 1995.
Nordestgaard, B.G., Wootton, R., Lewis, B. :
Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo - Molecular size as a determinant of fractional loss from the intima inner media Arteriosclerosis Thrombosis and Vascular Biology 15:534-542, 1995.
Ragazzi, E., Chinellato, A., Pandolfo, L., Froldi, G., Caparrotta, L., Aliev, G., Prosdocimi, M., Fassina, G. :
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits Journal of Cardiovascular Pharmacology 26:119-126, 1995. Pubmed reference: 7564351.
Sohma, Y., Sasano, H., Shiga, R., Saeki, S., Suzuki, T., Nagura, H., Nose, M., Yamamoto, T. :
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Proceedings of the National Academy of Sciences of the United States of America 92:4937-4941, 1995. Pubmed reference: 7761428.
Stewartlee, A.L., Ferns, G.A., Anggard, E.E. :
Differences in onset of impaired endothelial responses and in effects of vitamin E in the hypercholesterolemic rabbit carotid and renal arteries Journal of Cardiovascular Pharmacology 25:906-913, 1995. Pubmed reference: 7564335.
Tanaka, M., Otani, H., Yokode, M., Kita, T. :
Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia Atherosclerosis 114:73-82, 1995. Pubmed reference: 7605378.
Wu, C.C., Chang, S.W., Chen, M.S., Lee, Y.T. :
Early change of vascular permeability in hypercholesterolemic rabbits Arteriosclerosis Thrombosis and Vascular Biology 15:529-533, 1995.
Xu, G.R., Salen, G., Shefer, S., Ness, G.C., Nguyen, L.B., Parker, T.S., Chen, T.S., Zhao, Z.H., Donnelly, T.M., Tint, G.S. :
Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits Journal of Clinical Investigation 95:1497-1504, 1995. Pubmed reference: 7706454. DOI: 10.1172/JCI117821.
1994 Daugherty, A., Rateri, D.L. :
Presence of LDL receptor-related protein alpha(2)- macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits Arteriosclerosis and Thrombosis 14:2017-2024, 1994. Pubmed reference: 7526898.
Kinter, M., Robinson, C.S., Grimminger, L.C., Gillies, P.J., Shimshick, E.J., Ayers, C. :
Whole Blood and Plasma Concentrations of 4-Hydroxy-2-Nonenal in Watanabe Heritable Hyperlipidemic Versus New Zealand White Rabbits Biochemical and Biophysical Research Communications 199:671-675, 1994. Pubmed reference: 8135808. DOI: 10.1006/bbrc.1994.1280.
Kozarsky, K.F., Mckinley, D.R., Austin, L.L., Raper, S.E., Stratfordperricaudet, L.D., Wilson, J.M. :
In Vivo Correction of Low Density Lipoprotein Receptor Deficiency in the Watanabe Heritable Hyperlipidemic Rabbit with Recombinant Adenoviruses Journal of Biological Chemistry 269:13695-13702, 1994. Pubmed reference: 8175805.
Mamo, J.C.L., Bowler, A., Redgrave, T.G., Elsegood, C.L. :
Clearance of chylomicron-like lipid emulsions is increased in normal rabbits but not in heterozygous Watanabe heritable hyperlipidaemic rabbits following treatment with cholestyramine or pravastatin Clinical and Experimental Pharmacology & Physiology 21:687-694, 1994. Pubmed reference: 7820948.
Shiomi, M., Shiraishi, M., Yata, T., Ito, T. :
Effect of fluvastatin sodium on secretion of very low density lipoprotein and serum cholesterol levels - In vivo study using low density lipoprotein receptor deficient Watanabe heritable hyperlipidemic rabbits Arzneimittel - Forschung/Drug Research 44-2:1154-1156, 1994.
Sohma, Y., Suzuki, T., Sasano, H., Nagura, H., Nose, M., Yamamoto, T. :
Expression of mRNA for matrix gamma-carboxyglutamic acid protein during progression of atherosclerosis in aortae of Watanabe heritable hyperlipidemic rabbits Journal of Biochemistry 116:747-751, 1994. Pubmed reference: 7883748.
Sohma, Y., Suzuki, T., Sasano, H., Nagura, H., Nose, M., Yamamoto, T. :
Increased mRNA for CD63 antigen in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Cell Structure and Function 19:219-225, 1994. Pubmed reference: 7820873.
1993 Esper, E., Runge, W.J., Gunther, R., Buchwald, H. :
Natural History of Atherosclerosis and Hyperlipidemia in Heterozygous WHHL (WHHL-Hh) Rabbits .2. Morphologic Evaluation of Spontaneously Occurring Aortic and Coronary Lesions Journal of Laboratory and Clinical Medicine 121:103-110, 1993. Pubmed reference: 8426070.
Esper, E., Chan, E.K., Buchwald, H. :
Natural History of Atherosclerosis and Hyperlipidemia in Heterozygous WHHL (WHHL-Hh) Rabbits .1. The Effects of Aging and Gender on Plasma Lipids and Lipoproteins Journal of Laboratory and Clinical Medicine 121:97-102, 1993. Pubmed reference: 8426086.
Liu, R., Saku, K., Kostner, G.M., Hirata, K., Zhang, B., Shiomi, M., Arakawa, K. :
Invivo Kinetics of Lipoprotein(a) in Homozygous Watanabe Heritable Hyperlipidaemic Rabbits European Journal of Clinical Investigation 23:561-565, 1993. Pubmed reference: 8243527.
Pease, L.J., Robinson, C.S., Gillies, P.J., Bozarth, J.M., Reilly, T.M., Mousa, S.A. :
Increased Platelet GPIIb/IIIa Receptor Sensitivity in Watanabe Heritable Hyperlipidemic Rabbits Biochemical Archives 9:311-320, 1993.
Tagawa, H., Tomoike, H., Mitsuoka, W., Satoh, S., Kuga, T., Shimokawa, H., Nakamura, M., Takeshita, A. :
Hyperreactivity of Aortic Smooth Muscle to Serotonin Is Related to the Presence of Atheroma in Watanabe Heritable Hyperlipidaemic Rabbits Cardiovascular Research 27:2164-2169, 1993. Pubmed reference: 8313424.
Wanibuchi, H., Dingemans, K.P., Becker, A.E., Ueda, M., Naruko, T., Tanizawa, S., Nakamura, K. :
Is the Watanabe Heritable Hyperlipidemic Rabbit a Suitable Experimental Model for Percutaneous Transluminal Coronary Angioplasty in Humans? - A Light Microscopic, Immunohistochemical and Ultrastructural Study Journal of the American College of Cardiology 21:1490-1496, 1993. Pubmed reference: 8473661.
Westenend, P.J., Kroon, A.A., Stalenhoef, A.F.H., Assmann, K.H.J. :
Absence of Glomerulosclerosis in Watanabe Heritable Hyperlipidemic Rabbits Nephron 64:150-151, 1993. Pubmed reference: 8502322.
Willingham, A.K., Bolanos, C., Bohannan, E., Cenedella, R.J. :
The Effects of High Levels of Vitamin-E on the Progression of Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit Journal of Nutritional Biochemistry 4:651-654, 1993.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 29 Sep 2016
  • Changed by Imke Tammen2 on 22 Aug 2021
  • Changed by Imke Tammen2 on 25 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021
  • Changed by Imke Tammen2 on 10 Dec 2023