OMIA:000508-9615 : Hyperparathyroidism in Canis lupus familiaris

In other species: domestic cat , horse , mule

Categories: Endocrine / exocrine gland phene (incl mammary gland)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 145000 (trait) , 145001 (trait) , 239199 (trait) , 239200 (trait) , 256120 (trait) , 600166 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: yes

Key variant known: yes

Key variant is published: no

Molecular basis: The molecular basis of this disorder has not been published, but a DNA test for the disorder is included in the OFA's list at, which directs enquiries to the Goldstein Molecular and Genetics Laboratory at Cornell University (


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Thompson, D., Skelly, B. :
Prevalence of canine primary hyperparathyroidism recurrence in Keeshond and non-Keeshond dogs after curative parathyroidectomy. Vet Rec 187:e93, 2020. Pubmed reference: 32690764 . DOI: 10.1136/vr.105563.
2016 Bucy, D., Pollard, R., Nelson, R. :
Analysis of factors affecting outcome of ultrasound-guided radiofrequency heat ablation for treatment of primary hyperparathyroidism in dogs. Vet Radiol Ultrasound :, 2016. Pubmed reference: 27885739 . DOI: 10.1111/vru.12451.
2010 Sakals, SA., Gillick, MS., Kerr, ME., Boston, SE. :
Diagnosing the etiology of hypercalcemia in a dog: a case of primary hyperparathyroidism. Vet Pathol 47:579-81, 2010. Pubmed reference: 20472810 . DOI: 10.1177/0300985809359604.
2009 Benchekroun, G., Desmyter, A., Hidalgo, A., Boulouis, HJ., Gomes, E., Garnier, F., Escoffier, L., Poujol, L., de Fornel-Thibaud, P., Maurey, C., Rosenberg, D. :
Primary hyperparathyroidism and monoclonal gammopathy in a dog. J Vet Intern Med 23:211-4, 2009. Pubmed reference: 19175743 . DOI: 10.1111/j.1939-1676.2008.0223.x.
Ham, K., Greenfield, CL., Barger, A., Schaeffer, D., Ehrhart, EJ., Pinkerton, M., Valli, VE. :
Validation of a rapid parathyroid hormone assay and intraoperative measurement of parathyroid hormone in dogs with benign naturally occurring primary hyperparathyroidism. Vet Surg 38:122-32, 2009. Pubmed reference: 19152627 . DOI: 10.1111/j.1532-950X.2008.00457.x.
Schaefer, C., Goldstein, R.E. :
Canine primary hyperparathyroidism. Compend Contin Educ Vet 31:382-89, quiz 390, 2009. Pubmed reference: 19866445 .
2007 Bonczynski, J. :
Primary hyperparathyroidism in dogs and cats. Clin Tech Small Anim Pract 22:70-4, 2007. Pubmed reference: 17591292 . DOI: 10.1053/j.ctsap.2007.03.006.
Goldstein, RE., Atwater, DZ., Cazolli, DM., Goldstein, O., Wade, CM., Lindblad-Toh, K. :
Inheritance, mode of inheritance, and candidate genes for primary hyperparathyroidism in Keeshonden. J Vet Intern Med 21:199-203, 2007. Pubmed reference: 17338170 .
2005 Chuzel, T., Bublot, I., Mai, W. :
What is your diagnosis? Primary hyperparathyroidism. J Am Vet Med Assoc 226:203-4, 2005. Pubmed reference: 15706967 .
Gear, RN., Neiger, R., Skelly, BJ., Herrtage, ME. :
Primary hyperparathyroidism in 29 dogs: diagnosis, treatment, outcome and associated renal failure. J Small Anim Pract 46:10-6, 2005. Pubmed reference: 15682734 .
Higgins, MA., Rossmeisl, JH. :
What is your neurologic diagnosis? Hypoparathyroidism. J Am Vet Med Assoc 226:699-701, 2005. Pubmed reference: 15776941 .
2001 Pollard, R.E., Long, C.D., Nelson, R.W., Hornof, W.J., Feldman, E.C. :
Percutaneous ultrasonographically guided radiofrequency heat ablation for treatment of primary hyperparathyroidism in dogs Journal of the American Veterinary Medical Association 218:1106-1110, 2001. Pubmed reference: 11318360 .
1999 Long, C.D., Goldstein, R.E., Hornof, W.J., Feldman, E.C., Nyland, T.G. :
Percutaneous ultrasound-guided chemical parathyroid ablation for treatment of primary hyperparathyroidism in dogs Journal of the American Veterinary Medical Association 215:217-221, 1999. Pubmed reference: 10416475 .
Reusch, C., Glaus, T., Hoerauf, A., Grundmann, S., Unterer, S. :
Primary hyperparathyreodism in dogs - the significance of parathyroidea sonography in 5 cases [German] Kleintierpraxis 44:317-+, 1999.
1996 Brain, P.H., Lamb, W.A., Black, A.P. :
Primary hyperparathyroidism in a dog Australian Veterinary Practitioner 26:13-17, 1996.
Matwichuk, C.L., Taylor, S.M., Wilkinson, A.A., Dudzic, E.M., Matte, G.G., Outerbridge, C.A., Schmon, C.L., Ihle, S.L. :
Use of technetium tc 99M sestamibi for detection of a parathyroid adenoma in a dog with primary hyperparathyroidism Journal of the American Veterinary Medical Association 209:1733 ff., 1996.
1984 Thompson, KG., Jones, LP., Smylie, WA., Quick, CB., Segre, GV., Meuten, DJ., Petrites-Murphy, MB. :
Primary hyperparathyroidism in German shepherd dogs: a disorder of probable genetic origin. Vet Pathol 21:370-6, 1984. Pubmed reference: 6464298 .
1979 Carrillo, JM., Burk, RL., Bode, C. :
Primary hyperparathyroidism in a dog. J Am Vet Med Assoc 174:67-71, 1979. Pubmed reference: 457573 .
1976 Legendre, AM., Merkley, DF., Carrig, CB., Krehbiel, JD. :
Primary hyperparathyroidism in a dog. J Am Vet Med Assoc 168:694-6, 1976. Pubmed reference: 1262247 .
1974 Wilson, JW., Harris, SG., Moore, WD., Leipold, HW. :
Primary hyperparathyroidism in a dog. J Am Vet Med Assoc 164:942-6, 1974. Pubmed reference: 4132940 .
1968 Goulden, BE., MacKenzie, CP. :
Suspected primary hyperparathyroidism in the dog. N Z Vet J 16:131-40, 1968. Pubmed reference: 5249479 . DOI: 10.1080/00480169.1968.33760.
1965 Pearson, PT., Dellmann, HD., Berrier, HH., Case, AA., Collier, BL. :
Primary hyperparathyroidism in a beagle. J Am Vet Med Assoc 147:1201-6, 1965. Pubmed reference: 5894824 .

Edit History

  • Created by Frank Nicholas on 13 Jul 2011
  • Changed by Frank Nicholas on 24 Nov 2012