OMIA:000514-9615 : Hypertriglyceridaemia in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 145750 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Elevated fasting serum triglycerides concentrations are called Hypertriglyceridaemia. Primary Hypertriglyceridaemia is caused by genetic defects that cause abnormal triglyceride metabolism while secondary Hypertriglyceridaemia can be associated with other causes, such as nutrition, drugs, and/or other metabolic syndromes.

History: Thanks to Hamutal Mazrier for noting the previous lack of this entry (8 Jan 2015).

Molecular basis: Xenoulis et al. (2020) "concluded that coding variants in APOC2 are unlikely to be a major cause of idiopathic hypertriglyceridemia in North American Miniature Schnauzers".

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Miniature Schnauzer (Dog) (VBO_0200896).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000514-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Tate, N.M., Yamkate, P., Xenoulis, P.G., Steiner, J.M., Behling-Kelly, E.L., Rendahl, A.K., Wu, Y.A., Furrow, E. :
Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in Miniature Schnauzers. J Vet Intern Med , 2024. Pubmed reference: 38348783. DOI: 10.1111/jvim.17010.
2023 Bunn, T., Langner, K., Foster, S., Hayward, D., Howard, G., Paltrinieri, S., Giordano, A., Rossi, G. :
Lipoprotein profiles in Miniature Schnauzer dogs with idiopathic hypertriglyceridemia and hypercortisolism. J Vet Diagn Invest :10406387231217505, 2023. Pubmed reference: 38111301. DOI: 10.1177/10406387231217505.
2020 Xenoulis, P.G., Tate, N.M., Bishop, M.A., Steiner, J.M., Suchodolski, J.S., Furrow, E. :
Sequence analysis of the coding regions of the apolipoprotein C2 (APOC2) gene in Miniature Schnauzers with idiopathic hypertriglyceridemia. Vet J 265:105559, 2020. Pubmed reference: 33129550. DOI: 10.1016/j.tvjl.2020.105559.
2016 Furrow, E., Jaeger, J.Q., Parker, V.J., Hinchcliff, K.W., Johnson, S.E., Murdoch, S.J., de Boer, I.H., Sherding, R.G., Brunzell, J.D. :
Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia. Vet J 212:83-9, 2016. Pubmed reference: 27256031. DOI: 10.1016/j.tvjl.2016.04.009.
Furrow, E., Lees, G.E., Brown, C.A., Cianciolo, R.E. :
Glomerular Lesions in Proteinuric Miniature Schnauzer Dogs. Vet Pathol :300985816681412, 2016. Pubmed reference: 28005494. DOI: 10.1177/0300985816681412.
2011 Xenoulis, P.G., Levinski, M.D., Suchodolski, J.S., Steiner, J.M. :
Association of hypertriglyceridemia with insulin resistance in healthy Miniature Schnauzers. J Am Vet Med Assoc 238:1011-6, 2011. Pubmed reference: 21492044. DOI: 10.2460/javma.238.8.1011.
2008 Serisier, S., Gayet, C., Leray, V., Le Bloc'h, J., Ouguerram, K., Magot, T., Nguyen, P. :
Hypertriglyceridaemic insulin-resistant obese dog model: effects of high-fat diet depending on age. J Anim Physiol Anim Nutr (Berl) 92:419-25, 2008. Pubmed reference: 18662350. DOI: 10.1111/j.1439-0396.2007.00785.x.
Xenoulis, P.G., Suchodolski, J.S., Levinski, M.D., Steiner, J.M. :
Serum liver enzyme activities in healthy Miniature Schnauzers with and without hypertriglyceridemia. J Am Vet Med Assoc 232:63-7, 2008. Pubmed reference: 18167110. DOI: 10.2460/javma.232.1.63.
2007 Xenoulis, P.G., Suchodolski, J.S., Levinski, M.D., Steiner, J.M. :
Investigation of hypertriglyceridemia in healthy Miniature Schnauzers. J Vet Intern Med 21:1224-30, 2007. Pubmed reference: 18196730.
2003 Bailhache, E., Ouguerram, K., Gayet, C., Krempf, M., Siliart, B., Magot, T., Nguyen, P. :
An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique. J Anim Physiol Anim Nutr (Berl) 87:86-95, 2003. Pubmed reference: 14511132.
1993 Whitney, M.S., Boon, G.D., Rebar, A.H., Story, J.A., Bottoms, G.D. :
Ultracentrifugal and electrophoretic characteristics of the plasma lipoproteins of miniature schnauzer dogs with idiopathic hyperlipoproteinemia. J Vet Intern Med 7:253-60, 1993. Pubmed reference: 8246216. DOI: 10.1111/j.1939-1676.1993.tb01016.x.
1969 Baum, D., Schweid, A.I., Porte, D., Bierman, E.L. :
Congenital lipoprotein lipase deficiency and hyperlipemia in the young puppy. Proc Soc Exp Biol Med 131:183-5, 1969. Pubmed reference: 5814155.

Edit History

  • Created by Frank Nicholas on 08 Jan 2015
  • Changed by Frank Nicholas on 08 Jan 2015
  • Changed by Hamutal Mazrier on 29 Jan 2015
  • Changed by Hamutal Mazrier on 23 Mar 2017
  • Changed by Frank Nicholas on 03 Nov 2020