OMIA:000540-9615 : Hypotrichosis, generic in Canis lupus familiaris (dog) |
In other species: macaques , domestic cat , pig , taurine cattle , sheep , rabbit , golden hamster , Mongolian gerbil , meadow voles , domestic guinea pig , American mink
Categories: Integument (skin) phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 146520 (trait) , 146550 (trait) , 183849 (trait) , 211370 (trait) , 246500 (trait) , 250460 (trait) , 278200 (trait)
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Disease-related: yes
Key variant known: no
Cross-species summary: Also known as Hairless
Inheritance: There have been many isolated reports of this disorder, and it is impossible to tell whether they are alleleic or not. In the case of Chinese crested dogs, Robinson (1985) provided convincing evidence that hairlessness in this breed is a single-locus trait, and that hairless Chinese crested animals are heterozygous for an allele that is lethal when homozygous: matings among Chinese crested animals produced a ratio of normal to hairless much closer to 2:1 than 3:1.
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000540-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2005 | Sander, P., Drögemüller, C., Cadieu, E., André, C., Leeb, T. : |
| Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog. Anim Genet 36:168-71, 2005. Pubmed reference: 15771734. DOI: 10.1111/j.1365-2052.2005.01242.x. | |
| 2000 | Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. : |
| An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000) Veterinary Dermatology 11:313-314, 2000. | |
| Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. : | |
| An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom Vet Dermatol 11:107-122, 2000. Pubmed reference: 34645005. DOI: 10.1046/j.1365-3164.2000.00180.x. | |
| 1999 | Cerundolo, R., Lloyd, D.H., Pidduck, H.G. : |
| Studies on the inheritance of hair loss in the Irish water spaniel Veterinary Record 145:542-544, 1999. Pubmed reference: 10609570. | |
| De, Meulemeester, J., Lemmens, P., Schrauwen, E. : | |
| Congenital hypotrichosis in male Border Collie littermates Vlaams Diergeneeskundig Tijdschrift 68:179-181, 1999. | |
| Kimura, T., Doi, K. : | |
| Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids Toxicologic Pathology 27:528-535, 1999. Pubmed reference: 10528632. | |
| 1998 | Kimura, T., Doi, K. : |
| Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs Toxicologic Pathology 26:595-601, 1998. Pubmed reference: 9789945. | |
| Kimura, T., Doi, K. : | |
| Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs Histology & Histopathology 13:29-36, 1998. | |
| Kimura, T., Doi, K. : | |
| Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (xoloitzcuintli) Laboratory Animal Science 48:469-475, 1998. Pubmed reference: 10090060. | |
| 1997 | Gross, T.L., Pascal-Tenorio, A., Munn, R.J., Hargis, A.M., Kline, A. : |
| Follicular lipidosis in three Rottweilers. Vet Dermatol 8:33-39, 1997. Pubmed reference: 34645028. DOI: 10.1111/j.1365-3164.1997.tb00261.x. | |
| Ishii, Y., Kimura, T., Itagaki, S., Doi, K. : | |
| The skin injury induced by high energy dose of ultraviolet in hairless descendants of mexican hairless dogs Histology & Histopathology 12:383-389, 1997. | |
| Kimura, T., Doi, K. : | |
| The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of mexican hairless dogs Veterinary Dermatology 8:107-113, 1997. | |
| 1996 | Kimura, T., Doi, K. : |
| Spontaneous comedones on the skin of hairless descendants of mexican hairless dogs Jikken Dobutsu. Experimental Animals 45:377-384, 1996. | |
| Kimura, T. : | |
| Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science [Review] Jikken Dobutsu. Experimental Animals 45:1-13, 1996. | |
| Schwartzman, R.M., Kligman, A.M., Duclos, D.D. : | |
| The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids British Journal of Dermatology 134:64-70, 1996. Pubmed reference: 8745888. | |
| 1995 | Ishii, Y., Kimura, T., Itagaki, S., Doi, K. : |
| Ultrastructure of the dorsal skins of hairless descendants derived from Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:353-357, 1995. | |
| Kimura, T., Doi, K. : | |
| Dorsal skin reactions to sunlight and artificial ultraviolet light in hairless descendants of Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:293-299, 1995. | |
| 1994 | Kimura, T., Doi, K. : |
| Responses of the Skin over the Dorsum to Sunlight in Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:199-203, 1994. Pubmed reference: 8172407. | |
| Kimura, T., Doi, K. : | |
| Age-Related Changes in Skin Color and Histologic Features of Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:480-486, 1994. Pubmed reference: 8017693. | |
| Miyazawa, M., Kimura, T., Itagaki, S. : | |
| Lectin Histochemistry on the Skin of Hairless Descendants of Mexican Hairless Dogs Tissue & Cell 26:19-27, 1994. Pubmed reference: 8171420. | |
| 1993 | Kimura, T., Ohshima, S., Doi, K. : |
| The Inheritance and Breeding Results of Hairless Descendants of Mexican Hairless Dogs Laboratory Animals 27:55-58, 1993. Pubmed reference: 8437436. | |
| 1992 | Iwamura, S., Koizumi, N., Matsubara, Y., Honjo, K., Fukuta, K., Hirota, Y. : |
| Changes in the Level of Plasma Cortisol, Progesterone and Total Testosterone in Developing Hairless Dogs Journal of Veterinary Medical Science 54:1217-1218, 1992. Pubmed reference: 1477175. | |
| Kimura, T., Ohshima, S., Doi, K. : | |
| Haematological and Serum Biochemical Values in Hairless and Haired Descendants of Mexican Hairless Dogs Laboratory Animals 26:214-218, 1992. Pubmed reference: 1501437. | |
| Koizumi, N., Fukuta, K. : | |
| Lymphocyte Blastogenesis in Hairless Dogs Following Stimulation by Various Mitogens Experimental Animals 41:529-531, 1992. Pubmed reference: 1451763. | |
| Marks, A., Vandenbroek, A.H.M., Else, R.W. : | |
| Congenital Hypotrichosis in a French Bulldog Journal of Small Animal Practice 33:450-452, 1992. | |
| 1990 | Hirota, Y., Koizumi, N., Matsubara, Y., Imamura, K., Fukuta, K. : |
| Immunological Features in Hairless Descendants Derived from Mexican Hairless Dogs Japanese Journal of Veterinary Science 52:1117-1121, 1990. Pubmed reference: 1704076. | |
| Kimura, T., Ohshima, S., Iida, K. : | |
| Profile of Hematological Values in Hybrid Hairless Dogs Experimental Animals 39:417-420, 1990. Pubmed reference: 2401328. | |
| 1985 | Robinson, R. : |
| Chinese crested dog Journal of Heredity 76:217-218, 1985. Pubmed reference: 3998444. | |
| 1975 | Conroy, J.D., Rasmusen, B.A., Small, E. : |
| Hypotrichosis in Miniature Poodle siblings J Am Vet Med Assoc 166:697-9, 1975. Pubmed reference: 1141043. | |
| 1917 | Anon. : |
| The hairless dog Journal of Heredity 8:519-520, 1917. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 05 Aug 2013