OMIA 000540-9615 : Hypotrichosis in Canis lupus familiaris

In other species: domestic cat , cattle , rabbit , sheep , American mink , meadow voles , golden hamster , macaques , domestic guinea pig , Mongolian gerbil , pig , bottlenosed dolphin , long-beaked common dolphin , beluga whale , Indo-Pacific finless porpoise , Yangtze River dolphin , minke whale , Omura's baleen whale

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 146520 , 146550 , 183849 , 211370 , 246500 , 250460 , 278200

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: yes

Key variant known: no

Cross-species summary: Also known as Hairless

Inheritance: There have been many isolated reports of this disorder, and it is impossible to tell whether they are alleleic or not. In the case of Chinese crested dogs, Robinson (1985) provided convincing evidence that hairlessness in this breed is a single-locus trait, and that hairless Chinese crested animals are heterozygous for an allele that is lethal when homozygous: matings among Chinese crested animals produced a ratio of normal to hairless much closer to 2:1 than 3:1.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2005 Sander, P., Drögemüller, C., Cadieu, E., André, C., Leeb, T. :
Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog. Anim Genet 36:168-71, 2005. Pubmed reference: 15771734. DOI: 10.1111/j.1365-2052.2005.01242.x.
2000 Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000) Veterinary Dermatology 11:313-314, 2000.
Cerundolo, R., Lloyd, D.H., McNeil, P.E., Evans, H. :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom Veterinary Dermatology 11:107-122, 2000.
1999 Cerundolo, R., Lloyd, D.H., Pidduck, H.G. :
Studies on the inheritance of hair loss in the Irish water spaniel Veterinary Record 145:542-544, 1999. Pubmed reference: 10609570.
De, Meulemeester, J., Lemmens, P., Schrauwen, E. :
Congenital hypotrichosis in male Border Collie littermates Vlaams Diergeneeskundig Tijdschrift 68:179-181, 1999.
Kimura, T., Doi, K. :
Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids Toxicologic Pathology 27:528-535, 1999. Pubmed reference: 10528632.
1998 Kimura, T., Doi, K. :
Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs Toxicologic Pathology 26:595-601, 1998. Pubmed reference: 9789945.
Kimura, T., Doi, K. :
Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs Histology & Histopathology 13:29-36, 1998.
Kimura, T., Doi, K. :
Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (xoloitzcuintli) Laboratory Animal Science 48:469-475, 1998. Pubmed reference: 10090060.
1997 Ishii, Y., Kimura, T., Itagaki, S., Doi, K. :
The skin injury induced by high energy dose of ultraviolet in hairless descendants of mexican hairless dogs Histology & Histopathology 12:383-389, 1997.
Kimura, T., Doi, K. :
The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of mexican hairless dogs Veterinary Dermatology 8:107-113, 1997.
1996 Kimura, T. :
Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science [Review] Jikken Dobutsu. Experimental Animals 45:1-13, 1996.
Kimura, T., Doi, K. :
Spontaneous comedones on the skin of hairless descendants of mexican hairless dogs Jikken Dobutsu. Experimental Animals 45:377-384, 1996.
Schwartzman, R.M., Kligman, A.M., Duclos, D.D. :
The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids British Journal of Dermatology 134:64-70, 1996. Pubmed reference: 8745888.
1995 Ishii, Y., Kimura, T., Itagaki, S., Doi, K. :
Ultrastructure of the dorsal skins of hairless descendants derived from Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:353-357, 1995.
Kimura, T., Doi, K. :
Dorsal skin reactions to sunlight and artificial ultraviolet light in hairless descendants of Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:293-299, 1995.
1994 Kimura, T., Doi, K. :
Age-Related Changes in Skin Color and Histologic Features of Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:480-486, 1994. Pubmed reference: 8017693.
Kimura, T., Doi, K. :
Responses of the Skin over the Dorsum to Sunlight in Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:199-203, 1994. Pubmed reference: 8172407.
Miyazawa, M., Kimura, T., Itagaki, S. :
Lectin Histochemistry on the Skin of Hairless Descendants of Mexican Hairless Dogs Tissue & Cell 26:19-27, 1994. Pubmed reference: 8171420.
1993 Kimura, T., Ohshima, S., Doi, K. :
The Inheritance and Breeding Results of Hairless Descendants of Mexican Hairless Dogs Laboratory Animals 27:55-58, 1993. Pubmed reference: 8437436.
1992 Iwamura, S., Koizumi, N., Matsubara, Y., Honjo, K., Fukuta, K., Hirota, Y. :
Changes in the Level of Plasma Cortisol, Progesterone and Total Testosterone in Developing Hairless Dogs Journal of Veterinary Medical Science 54:1217-1218, 1992. Pubmed reference: 1477175.
Kimura, T., Ohshima, S., Doi, K. :
Haematological and Serum Biochemical Values in Hairless and Haired Descendants of Mexican Hairless Dogs Laboratory Animals 26:214-218, 1992. Pubmed reference: 1501437.
Koizumi, N., Fukuta, K. :
Lymphocyte Blastogenesis in Hairless Dogs Following Stimulation by Various Mitogens Experimental Animals 41:529-531, 1992. Pubmed reference: 1451763.
Marks, A., Vandenbroek, A.H.M., Else, R.W. :
Congenital Hypotrichosis in a French Bulldog Journal of Small Animal Practice 33:450-452, 1992.
1990 Hirota, Y., Koizumi, N., Matsubara, Y., Imamura, K., Fukuta, K. :
Immunological Features in Hairless Descendants Derived from Mexican Hairless Dogs Japanese Journal of Veterinary Science 52:1117-1121, 1990. Pubmed reference: 1704076.
Kimura, T., Ohshima, S., Iida, K. :
Profile of Hematological Values in Hybrid Hairless Dogs Experimental Animals 39:417-420, 1990. Pubmed reference: 2401328.
1985 Robinson, R. :
Chinese crested dog Journal of Heredity 76:217-218, 1985. Pubmed reference: 3998444.
1917 Anon. :
The hairless dog Journal of Heredity 8:519-520, 1917.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 05 Aug 2013