OMIA:000587-9823 : Amelia in Sus scrofa (pig) |
In other species: dog , horse , taurine cattle
Categories: Limbs / fins / digit / tail phene
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal
Disease-related: yes
Key variant known: no
Cross-species summary: Amelia is the congenital anomaly characterized by the complete absence of one or more limbs. Tetra-amelia is the absence of all for limbs. Phene was renamed from 'legless' to amelia [28/08/2023]
Species-specific name: legless
Species-specific description: Jiang et al. (2021) report a single piglet with missing hindlegs (amelia posterior). The authors did not perform an autopsy and conducted whole genome sequencing of the dam, the affected animal and an unaffected sibling.
Inheritance: Johnson and Lush (1939) provided convincing evidence of autosomal recessive inheritance of absence of all four limbs as a lethal disorder in pigs.
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000587-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 | Jiang, Y., Cao, X., Wang, H. : |
Comparative genomic analysis of a naturally born serpentized pig reveals putative mutations related to limb and bone development. BMC Genomics 22:629, 2021. Pubmed reference: 34454433. DOI: 10.1186/s12864-021-07925-3. | |
1982 | Ollivier, L., Sellier, P. : |
Pig genetics: a review Annales de Genetique et de Selection Animale 14:481-544, 1982. | |
1939 | Johnson, D.H., Lush, J.L. : |
"Legless", a new lethal in swine Genetics 24:79 only, 1939. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Imke Tammen2 on 28 Aug 2023