OMIA:000587-9823 : Amelia in Sus scrofa (pig)

In other species: dog , horse , taurine cattle

Categories: Limbs / fins / digit / tail phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: yes

Key variant known: no

Cross-species summary: Amelia is the congenital anomaly characterized by the complete absence of one or more limbs. Tetra-amelia is the absence of all for limbs. Phene was renamed from 'legless' to amelia [28/08/2023]

Species-specific name: legless

Species-specific description: Jiang et al. (2021) report a single piglet with missing hindlegs (amelia posterior). The authors did not perform an autopsy and conducted whole genome sequencing of the dam, the affected animal and an unaffected sibling.

Inheritance: Johnson and Lush (1939) provided convincing evidence of autosomal recessive inheritance of absence of all four limbs as a lethal disorder in pigs.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000587-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Jiang, Y., Cao, X., Wang, H. :
Comparative genomic analysis of a naturally born serpentized pig reveals putative mutations related to limb and bone development. BMC Genomics 22:629, 2021. Pubmed reference: 34454433. DOI: 10.1186/s12864-021-07925-3.
1982 Ollivier, L., Sellier, P. :
Pig genetics: a review Annales de Genetique et de Selection Animale 14:481-544, 1982.
1939 Johnson, D.H., Lush, J.L. :
"Legless", a new lethal in swine Genetics 24:79 only, 1939.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 28 Aug 2023