OMIA:000608-9031 : Loco, congenital in Gallus gallus (chicken)

In other species: turkey , Japanese quail

Categories: Behaviour / neurological phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive lethal

Considered a defect: yes

Key variant known: no

Cross-species summary: The main symptom is an apparent lack of control of the muscles of the neck of the chick, resulting in the inability to stand or eat normally

Species-specific symbol: lo

Inheritance: Knowlton (1929) provided evidence of autosomal recessive inheritance.

Mapping: Okumura et al. (2013) conducted a genome scan with 122 informative miccrosatellites on 88 Rhode Island Red chickens from several generations of families segregation for this disorder. Linkage analysis highlighted just one region near microsatellite MCW0332 on chromosome GGA12. Subsequent homozygosity mapping narrowed the region "to approximately 1.1 Mb, between GGA12_28 and GGA12_30", which contains at least 10 genes.

Breed: Rhode Island Red (Chicken) (VBO_0000599).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:000608-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2013 Okumura, Y., Ohtake, T., Uemoto, Y., Sato, S., Sato, S., Kobayashi, E. :
Fine mapping of the chicken congenital loco locus on chromosome 12. Anim Genet 44:778-781, 2013. Pubmed reference: 23742667 . DOI: 10.1111/age.12065.
1934 Hutt, F.B. :
Inherited lethal characters in domestic animals Cornell Veterinarian 24:1-25, 1934.
1929 Knowlton, F.L. :
Congenital loco in chicks Oregon Agr. Expt Sta. Bull. 25:3, 1929.

Edit History

  • Created by Frank Nicholas on 24 Oct 2011
  • Changed by Frank Nicholas on 09 Jun 2013