OMIA:000608-9031 : Loco, congenital in Gallus gallus (chicken)
Categories: Behaviour / neurological phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive lethal
Considered a defect: yes
Key variant known: no
Cross-species summary: The main symptom is an apparent lack of control of the muscles of the neck of the chick, resulting in the inability to stand or eat normally
Species-specific symbol: lo
Inheritance: Knowlton (1929) provided evidence of autosomal recessive inheritance.
Mapping: Okumura et al. (2013) conducted a genome scan with 122 informative miccrosatellites on 88 Rhode Island Red chickens from several generations of families segregation for this disorder. Linkage analysis highlighted just one region near microsatellite MCW0332 on chromosome GGA12. Subsequent homozygosity mapping narrowed the region "to approximately 1.1 Mb, between GGA12_28 and GGA12_30", which contains at least 10 genes.
Rhode Island Red (Chicken) (VBO_0000599).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2013||Okumura, Y., Ohtake, T., Uemoto, Y., Sato, S., Sato, S., Kobayashi, E. :|
|Fine mapping of the chicken congenital loco locus on chromosome 12. Anim Genet 44:778-781, 2013. Pubmed reference: 23742667 . DOI: 10.1111/age.12065.|
|1934||Hutt, F.B. :|
|Inherited lethal characters in domestic animals Cornell Veterinarian 24:1-25, 1934.|
|1929||Knowlton, F.L. :|
|Congenital loco in chicks Oregon Agr. Expt Sta. Bull. 25:3, 1929.|
- Created by Frank Nicholas on 24 Oct 2011
- Changed by Frank Nicholas on 09 Jun 2013