OMIA 000608-9031 : Loco, congenital in Gallus gallus

In other species: turkey , Japanese quail

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive Lethal

Considered a defect: yes

Key variant known: no

Species-specific symbol: lo

Inheritance: Knowlton (1929) provided evidence of autosomal recessive inheritance.

Mapping: Okumura et al. (2013) conducted a genome scan with 122 informative miccrosatellites on 88 Rhode Island Red chickens from several generations of families segregation for this disorder. Linkage analysis highlighted just one region near microsatellite MCW0332 on chromosome GGA12. Subsequent homozygosity mapping narrowed the region "to approximately 1.1 Mb, between GGA12_28 and GGA12_30", which contains at least 10 genes.

Breed: Rhode Island Red.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2013 Okumura, Y., Ohtake, T., Uemoto, Y., Sato, S., Sato, S., Kobayashi, E. :
Fine mapping of the chicken congenital loco locus on chromosome 12. Anim Genet :, 2013. Pubmed reference: 23742667. DOI: 10.1111/age.12065.
1934 Hutt, F.B. :
Inherited lethal characters in domestic animals Cornell Veterinarian 24:1-25, 1934.
1929 Knowlton, F.L. :
Congenital loco in chicks Oregon Agr. Expt Sta. Bull. 25:3, 1929.

Edit History


  • Created by Frank Nicholas on 24 Oct 2011
  • Changed by Frank Nicholas on 09 Jun 2013