OMIA:000660-9913 : Mortality in Bos taurus (taurine cattle)

In other species: pig

Categories: Mortality / aging (incl. embryonic lethal)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific description: Sasaki et al. (2021): "To identify variants associated with calf mortality in Japanese Black cattle, we evaluated calf mortality as a categorical trait with a threshold model and performed a genome-wide copy number variation (CNV) association study on calf mortality. ... We identified a 44-kb deleted-type CNV ranging from 103,317,687 to 103,361,802 bp on chromosome 5, which was associated with the mortality of 1–180-day-old calves." Sasaki and Ibi (2021) also "evaluated calf mortality as a categorical trait using a threshold model and conducted a GWAS. We identified two SNPs between 32 549 297 and 32 606 924 bp on bovine chromosome 9 that were significantly associated with calf mortality from 61 to 180 days after birth. The SNP showing the highest association was localized at a region 624 bp downstream of exon 4 of the anti-silencing function 1A histone chaperone gene (ASF1A) ..." Cai et al. (2023): "To identify mutations and genes underlying young stock survival (YSS), we performed GWAS using de-regressed estimated breeding values of a YSS index and its component traits defined by sex and age in 3,077 Nordic Red Dairy Cattle (RDC) bulls and 2 stillbirth traits (first lactation and later lactations) in 5,141 RDC bulls. Two associated QTL regions on Bos taurus autosome (BTA) 4 and 6 were identified for the YSS index. ... The GWAS on stillbirth identified 3 additional QTL regions on BTA5, 14, and 24 compared with YSS and its component traits."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000660-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Cai, Z., Wu, X., Thomsen, B., Lund, M.S., Sahana, G. :
Genome-wide association study identifies functional genomic variants associated with young stock survival in Nordic Red Dairy Cattle. J Dairy Sci , 2023. Pubmed reference: 37641238. DOI: 10.3168/jds.2023-23252.
2021 Sasaki, S., Miki, Y., Ibi, T., Wakaguri, H., Yoshida, Y., Sugimoto, Y., Suzuki, Y. :
A 44-kb deleted-type copy number variation is associated with decreasing complement component activity and calf mortality in Japanese Black cattle. BMC Genomics 22:107, 2021. Pubmed reference: 33549039. DOI: 10.1186/s12864-021-07415-6.
Sasaki, S., Ibi, T. :
A genome-wide association study reveals a quantitative trait locus for calf mortality on chromosome 9 in Japanese Black cattle. Anim Genet 52:214-216, 2021. Pubmed reference: 33544945. DOI: 10.1111/age.13048.

Edit History

  • Created by Imke Tammen2 on 09 Apr 2021
  • Changed by Imke Tammen2 on 09 Apr 2021
  • Changed by Imke Tammen2 on 30 Aug 2023