OMIA 000660-9913 : Mortality in Bos taurus

In other species: pig

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific description: Sasaki et al. (2021): "To identify variants associated with calf mortality in Japanese Black cattle, we evaluated calf mortality as a categorical trait with a threshold model and performed a genome-wide copy number variation (CNV) association study on calf mortality. ... We identified a 44-kb deleted-type CNV ranging from 103,317,687 to 103,361,802 bp on chromosome 5, which was associated with the mortality of 1–180-day-old calves."

Sasaki and Ibi (2021) also "evaluated calf mortality as a categorical trait using a threshold model and conducted a GWAS. We identified two SNPs between 32 549 297 and 32 606 924 bp on bovine chromosome 9 that were significantly associated with calf mortality from 61 to 180 days after birth. The SNP showing the highest association was localized at a region 624 bp downstream of exon 4 of the anti-silencing function 1A histone chaperone gene (ASF1A) ..."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Sasaki, S., Miki, Y., Ibi, T., Wakaguri, H., Yoshida, Y., Sugimoto, Y., Suzuki, Y. :
A 44-kb deleted-type copy number variation is associated with decreasing complement component activity and calf mortality in Japanese Black cattle. BMC Genomics 22:107, 2021. Pubmed reference: 33549039. DOI: 10.1186/s12864-021-07415-6.
Sasaki, S., Ibi, T. :
A genome-wide association study reveals a quantitative trait locus for calf mortality on chromosome 9 in Japanese Black cattle. Anim Genet 52:214-216, 2021. Pubmed reference: 33544945. DOI: 10.1111/age.13048.

Edit History


  • Created by Imke Tammen2 on 09 Apr 2021
  • Changed by Imke Tammen2 on 09 Apr 2021