OMIA:000676-9796 : Shivers in Equus caballus (horse)

Categories: Nervous system phene

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Purkinje cell axonopathy

Species-specific name: Shivering

Species-specific description: Valberg et al. (2023): "Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. ... Differences in gene expression between Shivers and control horses were evident in principal component analysis of axon-containing white matter but not PC soma. ... Our findings support axonal degeneration as a characteristic feature of Shivers."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000676-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Valberg, S.J., Willams, Z.J., Henry, M.L., Finno, C.J. :
Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses. J Vet Intern Med , 2023. Pubmed reference: 37288990. DOI: 10.1111/jvim.16784.
2022 Valberg, S.J., Baird, J.D. :
Shivering and Stringhalt in horses. Vet J 282:105829, 2022. Pubmed reference: 35462036. DOI: 10.1016/j.tvjl.2022.105829.
2018 Aman, J.E., Valberg, S.J., Elangovan, N., Nicholson, A., Lewis, S.S., Konczak, J. :
Abnormal locomotor muscle recruitment activity is present in horses with shivering and Purkinje cell distal axonopathy. Equine Vet J 50:636-643, 2018. Pubmed reference: 29356055. DOI: 10.1111/evj.12813.
2015 Valberg, S.J., Lewis, S.S., Shivers, J.L., Barnes, N.E., Konczak, J., Draper, A.C., ArmiƩn, A.G. :
The equine movement disorder "Shivers" is associated with selective cerebellar Purkinje cell axonal degeneration. Vet Pathol 52:1087-98, 2015. Pubmed reference: 25714471. DOI: 10.1177/0300985815571668.
2013 Finno, C.J., Valberg, S.J., Petersen, J., Draper, A., Livesey, L., Brock, J., Baird, J., McCue, M.E. :
Genome-wide association analysis of Shivers in Belgian horses. Equine Genome Workshop, Plan and Animal Genome XXI, San Diego, CA :142, 2013.
1999 Valentine, B.A., de, Lahunta, A., Divers, T.J., Ducharme, N.G., Orcutt, R.S. :
Clinical and pathologic findings in two draft horses with progressive muscle atrophy, neuromuscular weakness, and abnormal gait characteristic of shivers syndrome Journal of the American Veterinary Medical Association 215:1661-+, 1999. Pubmed reference: 14567431.
1955 Ogura, K. :
Lumbar lameness caused by inherited muscle atrophy inhorse Journal of the Japanese Veterinary Medical Association 8:349-351, 1955.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 26 Oct 2011
  • Changed by Imke Tammen2 on 09 Nov 2021
  • Changed by Imke Tammen2 on 11 Sep 2022
  • Changed by Imke Tammen2 on 10 Jun 2023