OMIA:000706-9615 : Necrotising myelopathy in Canis lupus familiaris

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

History: Opmeer et al. (2023): "... the first hereditary disease identified in the [Nederlandse Kooikerhondje] breed was hereditary necrotizing myelopathy [Mandigers et al. 1993]. Cases were seen as of 1962, and eradication of hereditary necrotizing myelopathy by selective breeding only became possible after the discovery of the causative mutation (Mandigers and Leegwater, unpublished data) in 2015."


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Opmeer, Y., Grinwis, G.C.M., Shelton, G.D., Rosati, M., Alf, V., Fieten, H., Leegwater, P.A.J., Matiasek, K., Mandigers, P.J.J. :
An inflammatory myopathy in the Dutch Kooiker dog. Animals (Basel) 13:, 2023. Pubmed reference: 37174546 . DOI: 10.3390/ani13091508.
1993 Mandigers, P.J., van Nes, J.J., Knol, B.W., Ubbink, G.J., Gruys, E. :
Hereditary Kooiker dog ataxia. Tijdschr. Voor Diergeneeskd. 118(Suppl. S1):65S, 1993.
Mandigers, P.J.J., Vannes, J.J., Knol, B.W., Ubbink, G.J., Gruys, E. :
Hereditary necrotising myelopathy in Kooiker dogs. Research in Veterinary Science 54:118-123, 1993. Pubmed reference: 8434139 .
1978 Cummings, J.F., de Lahunta, A. :
Hereditary myelopathy of Afghan hounds, a myelinolytic disease. Acta Neuropathol 42:173-81, 1978. Pubmed reference: 676666 . DOI: 10.1007/bf00690354.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 15 May 2023