OMIA:000709-9685 : Nephrolithiasis in Felis catus (domestic cat)

Categories: Renal / urinary system phene

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Nephrolithiasis is the formation of uroliths (i.e. stones) in the renal pelvis.

Species-specific description: Upper urinary tract uroliths make of 4% of all uroliths affecting the urinary tract (Gomes et al., 2018). Etiology of nephrolithiasis may be multifactorial and consequently inducing the syndrome of urolithiasis (see also OMIA 001033-9685 : Urolithiasis in Felis catus). Cats have experienced a 10-fold increase in frequency of nephroliths in the past 20 years, of which calcium oxalate make up 70% of those uroliths (Osborne et al., 2009). See 'OMIA 000821-9685 : Hyperoxaluria, primary, type II (Oxalosis II) in Felis catus' for additional inforamtion on calcium oxalate nephrolithiasis. 56% of cats with uroliths suffer from chronic kidney disease (Osborne et al., 2009). (Compiled by Rachel Natsume 13/9/2021)

Clinical features: Often asymptomatic with non-specific hematuria (Osborne et al., 1996). (Compiled by Rachel Natsume 13/9/2021)

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000709-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2018 Gomes, V.D.R., Ariza, P.C., Borges, N.C., Schulz, F.J., Fioravanti, M.C.S. :
Risk factors associated with feline urolithiasis. Vet Res Commun 42:87-94, 2018. Pubmed reference: 29340849. DOI: 10.1007/s11259-018-9710-8.
2017 O'Kell, A.L., Grant, D.C., Khan, S.R. :
Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats. Urolithiasis 45:329-336, 2017. Pubmed reference: 28361470. DOI: 10.1007/s00240-017-0978-x.
2012 Suzuki, T., Uetsuka, K., Doi, K., Nunoya, T. :
A case of renal oxalosis in a 3-month-old cat raised under controlled conditions. J Vet Med Sci 74:381-4, 2012. Pubmed reference: 22067080. DOI: 10.1292/jvms.11-0399.
2009 Gisselman, K., Langston, C., Palma, D., McCue, J. :
Calcium oxalate urolithiasis. Compend Contin Educ Vet 31:496-502; quiz 502, 2009. Pubmed reference: 20180219.
Lulich, J.P., Osborne, C.A. :
Changing paradigms in the diagnosis of urolithiasis. Vet Clin North Am Small Anim Pract 39:79-91, 2009. Pubmed reference: 19038652. DOI: 10.1016/j.cvsm.2008.10.005.
Osborne, C.A., Lulich, J.P., Kruger, J.M., Ulrich, L.K., Koehler, L.A. :
Analysis of 451,891 canine uroliths, feline uroliths, and feline urethral plugs from 1981 to 2007: perspectives from the Minnesota Urolith Center. Vet Clin North Am Small Anim Pract 39:183-97, 2009. Pubmed reference: 19038658. DOI: 10.1016/j.cvsm.2008.09.011.
2008 Robinson, M.R., Norris, R.D., Sur, R.L., Preminger, G.M. :
Urolithiasis: not just a 2-legged animal disease. J Urol 179:46-52, 2008. Pubmed reference: 17997446. DOI: 10.1016/j.juro.2007.08.123.
2007 Ross, S.J., Osborne, C.A., Lekcharoensuk, C., Koehler, L.A., Polzin, D.J. :
A case-control study of the effects of nephrolithiasis in cats with chronic kidney disease. J Am Vet Med Assoc 230:1854-9, 2007. Pubmed reference: 17571990. DOI: 10.2460/javma.230.12.1854.
2005 Lekcharoensuk, C., Osborne, C.A., Lulich, J.P., Albasan, H., Ulrich, L.K., Koehler, L.A., Carpenter, K.A., Swanson, L.L., Pederson, L.A. :
Trends in the frequency of calcium oxalate uroliths in the upper urinary tract of cats. J Am Anim Hosp Assoc 41:39-46, 2005. Pubmed reference: 15634865. DOI: 10.5326/0410039.
2000 Lekcharoensuk, C., Lulich, J.P., Osborne, C.A., Koehler, L.A., Urlich, L.K., Carpenter, K.A., Swanson, L.L. :
Association between patient-related factors and risk of calcium oxalate and magnesium ammonium phosphate urolithiasis in cats Journal of the American Veterinary Medical Association 217:520-525, 2000. Pubmed reference: 10953716.
1999 Ross, S.J., Osborne, C.A., Lulich, J.P., Polzin, D.J., Ulrich, L.K., Koehler, L.A., Bird, K.A., Swanson, L.L. :
Canine and feline nephrolithiasis. Epidemiology, detection, and management. Vet Clin North Am Small Anim Pract 29:231-50, xiii-xiv, 1999. Pubmed reference: 10028160.
1998 Ling, G.V., Ruby, A.L., Johnson, D.L., Thurmond, M., Franti, C.E. :
Renal calculi in dogs and cats: prevalence, mineral type, breed, age, and gender interrelationships (1981-1993). J Vet Intern Med 12:11-21, 1998. Pubmed reference: 9503355. DOI: 10.1111/j.1939-1676.1998.tb00491.x.
1993 Carter, W.O., Hawkins, E.C., Morrison, W.B. :
Feline Nephrolithiasis - 8 Cases (1984 Through 1989) Journal of the American Animal Hospital Association 29:247-256, 1993.
1971 Ryan, C.P., Smith, R.A. :
Bilateral nephrolithiasis in a cat. J Am Vet Med Assoc 158:1946-7, 1971. Pubmed reference: 5107324.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 13 Sep 2021