OMIA:000712-9615 : Nephrotic syndrome in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Renal / urinary system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 251300 (trait) , 256020 (trait) , 600995 (trait) , 256370 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Nephrotic syndrome is a kidney disorder in which the body excretes too much protein in the urine. The syndrome is characterised by proteinuria, hypoalbuminaemia and oedema. Nephrotic syndrome is often caused by damage to small blood vessels in the kidneys and can be the consequence of various underlying health conditions, including glomerulonephritis and amyloidosis. Several inherited forms have been described in humans.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000712-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2011 Klosterman, E.S., Pressler, B.M. :
Nephrotic syndrome in dogs: clinical features and evidence-based treatment considerations. Top Companion Anim Med 26:135-42, 2011. Pubmed reference: 21782144. DOI: 10.1053/j.tcam.2011.04.004.
Klosterman, E.S., Moore, G.E., de Brito Galvao, J.F., DiBartola, S.P., Groman, R.P., Whittemore, J.C., Vaden, S.L., Harris, T.L., Byron, J.K., Dowling, S.R., Grant, D.C., Grauer, G.F., Pressler, B.M. :
Comparison of signalment, clinicopathologic findings, histologic diagnosis, and prognosis in dogs with glomerular disease with or without nephrotic syndrome. J Vet Intern Med 25:206-14, 2011. Pubmed reference: 21281353. DOI: 10.1111/j.1939-1676.2010.0669.x.
1997 Ritt, M.G., Rogers, K.S., Thomas, J.S. :
Nephrotic syndrome resulting in thromboembolic disease and disseminated intravascular coagulation in a dog Journal of the American Animal Hospital Association 33:385-391, 1997. Pubmed reference: 9278113.
1996 Relford, R.L., Leed, G.E. :
Nephrotic syndrome in dogs - diagnosis and treatment Compendium on Continuing Education for the Practicing Veterinarian 18:279 ff., 1996.
1995 Clements, C.A., Rogers, K.S., Green, R.A., Loy, J.K. :
Splenic vein thrombosis resulting in acute anemia: an unusual manifestation of nephrotic syndrome in a Chinese shar pei with reactive amyloidosis. J Am Anim Hosp Assoc 31:411-5, 1995. Pubmed reference: 8542358.
1994 Vilafranca, M., Ferrer, L. :
Juvenile nephropathy in Alaskan Malamute littermate Veterinary Pathology 31:375-377, 1994. Pubmed reference: 8053133.
Vilafranca, M., Wohlsein, P., Trautwein, G., Leopoldtemmler, B., Nolte, I. :
Histological and immunohistological classification of canine glomerular disease Journal of Veterinary Medicine Series A - Zentralblatt Fur Veterinarmedizin Reihe A - Physiology Pathology Clinical Medicine 41:599-610, 1994.
Vilafranca, M., Ferrer, L., Wohlsein, P., Trautwein, G. :
Participation of monocytes and macrophages in canine glomerular disease Journal of Veterinary Medicine Series A - Zentralblatt Fur Veterinarmedizin Reihe A - Physiology Pathology Clinical Medicine 41:770-779, 1994.
1993 Vilafranca, M., Wohlsein, P., Leopoldtemmler, B., Trautwein, G. :
A Canine Nephropathy Resembling Minimal Change Nephrotic Syndrome in Man Journal of Comparative Pathology 109:271-280, 1993. Pubmed reference: 8300915.
1992 Grauer, G.F., Frisbie, D.D., Snyder, P.S., Dubielzig, R.R., Panciera, D.L. :
Treatment of membranoproliferative glomerulonephritis and nephrotic syndrome in a dog with a thromboxane synthetase inhibitor. J Vet Intern Med 6:77-81, 1992. Pubmed reference: 1588545.
1986 Rasedee, A., Feldman, B.F., Washabau, R. :
Naturally occurring canine nephrotic syndrome is a potentially hypercoagulable state. Acta Vet Scand 27:369-77, 1986. Pubmed reference: 3565198.
1985 Green, R.A., Russo, E.A., Greene, R.T., Kabel, A.L. :
Hypoalbuminemia-related platelet hypersensitivity in two dogs with nephrotic syndrome. J Am Vet Med Assoc 186:485-8, 1985. Pubmed reference: 2982777.
1982 Green, R.A., Kabel, A.L. :
Hypercoagulable state in three dogs with nephrotic syndrome: role of acquired antithrombin III deficiency. J Am Vet Med Assoc 181:914-7, 1982. Pubmed reference: 6815144.
1978 Müller-Peddinghaus, R., Drommer, W., Wirth, W., Kersten, U., Trautwein, G. :
[Nephrotic syndrome and idiopathic membranous glomerulonephritis in 2 dogs]. Zentralbl Veterinarmed A 25:341-62, 1978. Pubmed reference: 100987.
Müller-Peddinghaus, R., Drommer, W., Trautwein, G., Wirth, W., Kersten, U. :
[Idiopathic membranous glomerulonephritis with nephrotic syndrome in dogs]. Verh Dtsch Ges Pathol 62:354, 1978. Pubmed reference: 154789.
1974 De Schepper, J., Hoorens, J., Mattheeuws, D., Van Der Stock, J. :
Gluomerulonephritis and the nephrotic syndrome in a dog. Vet Rec 95:434-7, 1974. Pubmed reference: 4450409.
1972 Larkin, H.A., Lucke, V.M., Kidder, D.E. :
Nephrotic syndrome in a dog. J Small Anim Pract 13:333-7, 1972. Pubmed reference: 5077657.
1971 Watson, A.D. :
The nephrotic syndrome due to renal amyloidosis in a dog. Aust Vet J 47:398-401, 1971. Pubmed reference: 5106798.
1969 Osborne, C.A., Johnson, K.H., Perman, V. :
Amyloid nephrotic syndrome in the dog. J Am Vet Med Assoc 154:1545-60, 1969. Pubmed reference: 5814951.
1966 Opitz, M. :
[Nephrotic syndrome in dogs]. Berl Munch Tierarztl Wochenschr 79:425-9 concl, 1966. Pubmed reference: 5951407.
Opitz, M. :
[Nephrotic syndrome in dogs]. Berl Munch Tierarztl Wochenschr 79:417-9 contd, 1966. Pubmed reference: 6009949.
Rijnberk, A. :
A nephrotic syndrome in the dog, treated with prednisone. Zentralbl Veterinarmed A 13:102-10, 1966. Pubmed reference: 4962415.

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  • Created by Frank Nicholas on 06 Sep 2005