OMIA:000712-9685 : Nephrotic syndrome in Felis catus (domestic cat)

In other species: dog

Categories: Renal / urinary system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 251300 (trait) , 256020 (trait) , 600995 (trait) , 256370 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Nephrotic syndrome is a kidney disorder in which the body excretes too much protein in the urine. The syndrome is characterised by proteinuria, hypoalbuminaemia and oedema. Nephrotic syndrome is often caused by damage to small blood vessels in the kidneys and can be the consequence of various underlying health conditions, including glomerulonephritis and amyloidosis. Several inherited forms have been described in humans.

Species-specific description: Nephrotic syndrome is often the consequence of underlying glomerular disease (White et al., 2008). See also: 'OMIA 000413-9685 : Glomerulonephritis in Felis catus' and 'OMIA 000040-9685 : Amyloidosis, renal in Felis catus' (Compiled by Rachel Natsume 13/9/2021)

Inheritance: White et al., (2008) describe eight cases of glomerular disease in young, related Abyssinian cats and propose a possible recessive mode of inheritance in these cats.

Clinical features: Presentation with proteinuria, hypoproteinemia (hypoalbuminemia), hypercholesteremia, edema and/or effusion. Although peripheral subcutaneous edema is uncommon in cats, it may be present with severe hypoproteinemia (Farrow and Huxtable, 1971). Pleural effusion and ascites have been reported (White et al., 2008). Persistent proteinuria will exacerbate glomerular damage and may lead to renal failure (Kamie et al., 2010). (Compiled by Rachel Natsume 13/9/2021)

Breed: Abyssinian (Cat) (VBO_0100000).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:000712-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2011 Kamiie, J., Haishima, A., Inoue, K., Ogihara, K., Ono, M., Yasuno, K., Kobayashi, R., Aihara, N., Ohmuro, T., Shirota, K. :
Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome. J Vet Med Sci 73:129-32, 2011. Pubmed reference: 20823662.
2008 White, J.D., Norris, J.M., Bosward, K.L., Fleay, R., Lauer, C., Malik, R. :
Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats. J Feline Med Surg 10:219-29, 2008. Pubmed reference: 18455462. DOI: 10.1016/j.jfms.2007.11.007.
1981 Shull, R.M., Stowe, C.M., Osborne, C.A., O'Leary, T.P., Vernier, R.L., Hammer, R.F. :
Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. Vet Hum Toxicol 23:1-5, 1981. Pubmed reference: 7257162.
Wright, N.G., Nash, A.S., Thompson, H., Fisher, E.W. :
Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases. Lab Invest 45:269-77, 1981. Pubmed reference: 7024632.
1971 Farrow, B.R., Huxtable, C.R. :
Membranous nephropathy and the nephrotic syndrome in the cat. J Comp Pathol 81:463-7, 1971. Pubmed reference: 5167495.
1969 Farrow, B.R., Huxtable, C.R., McGovern, V.J. :
Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology 1:67-72, 1969. Pubmed reference: 5408671.
1959 Johnson, J.R., Reader, R. :
Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child. Australas Ann Med 8:200-9, 1959. Pubmed reference: 14407479. DOI: 10.1111/imj.1959.8.3.200.

Edit History

  • Created by Frank Nicholas on 17 Nov 2011
  • Changed by Imke Tammen2 on 13 Sep 2021