OMIA 000720-9615 : Neurological syndrome in Canis lupus familiaris |
"a) early age of onset (3–4 weeks of age),
b) characteristic clinical signs (pups exhibit crooked necks and carry heads low, stiffened posture, and staggering gait; appear blind; begin to cry, often incessantly; lose muscle tone and the ability to stand),
c) progression to recumbency by 5–6 weeks of age,
d) multiple pups generally affected in each litter,
e) identification of swollen astrocytes primarily in the cerebellar and cerebrocortical white matter and white matter tracts of the brainstem,
f) identification of increased numbers of GFAP-stained astrocyte cytoplasmic processes (this lesion is most readily visualized in the cortical white matter and granular layer of the cerebellum), and
g) exclusion of other disease processes."
Breed: Gordon Setter.Reference
2000 | Yaeger, M.J., Majercik, K., Carter, M., Rothschild, M. : | |
An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies. J Vet Diagn Invest 12:570-3, 2000. Pubmed reference: 11108461. |
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- Created by Frank Nicholas on 03 Jul 2013
- Changed by Frank Nicholas on 03 Jul 2013