OMIA:000747-9796 : Osteoarthritis in Equus caballus (horse)

In other species: dog , domestic cat , pig , taurine cattle , sheep , domestic guinea pig , sea otter , koala

Categories: Skeleton phene (incl. short stature & teeth)

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 165720 (trait) , 140600 (trait) , 607850 (trait) , 610839 (trait) , 612400 (trait) , 612401 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2005). OMIA:000747-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Antunes, J., Salcedo-Jiménez, R., Lively, S., Potla, P., Coté, N., Dubois, M.S., Koenig, J., Kapoor, M., LaMarre, J., Koch, T.G. :
microRNAs are differentially expressed in equine plasma of horses with osteoarthritis and osteochondritis dissecans versus control horses. PLoS One 19:e0297303, 2024. Pubmed reference: 38394252. DOI: 10.1371/journal.pone.0297303.
Jasiński, T., Turek, B., Kaczorowski, M., Brehm, W., Skierbiszewska, K., Bonecka, J., Domino, M. :
Equine models of temporomandibular joint osteoarthritis: A review of feasibility, biomarkers, and molecular signaling. Biomedicines 12:542, 2024. Pubmed reference: 38540155. DOI: 10.3390/biomedicines12030542.
2023 Mayet, A., Zablotski, Y., Roth, S.P., Brehm, W., Troillet, A. :
Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. Front Vet Sci 10:1125695, 2023. Pubmed reference: 36908512. DOI: 10.3389/fvets.2023.1125695.
2022 Wrangberg, T., Kendall, A. :
Who is healthy? A review of how equine control groups are defined in clinical orthopaedic research 1999-2021. Vet Comp Orthop Traumatol 35:213-219, 2022. Pubmed reference: 35512819. DOI: 10.1055/s-0042-1745756.
2017 Mills, J.S., Kinsley, M.A., Peters, D.F., Weber, P.S.D., Shearer, T.R., Pease, A.P. :
Correlation of dickkopf-1 concentrations in plasma and synovial fluid to the severity of radiographic signs of equine osteoarthritis. Vet Comp Orthop Traumatol 30, 2017. Pubmed reference: 28763521. DOI: 10.3415/VCOT-16-11-0157.
2016 Reesink, H.L., Watts, A.E., Mohammed, H.O., Jay, G.D., Nixon, A.J. :
Lubricin/Proteoglycan 4 Increases in both Experimental and Naturally Occurring Equine Osteoarthritis. Osteoarthritis Cartilage , 2016. Pubmed reference: 27498214. DOI: 10.1016/j.joca.2016.07.021.
2013 Welsh, C.E., Lewis, T.W., Blott, S.C., Mellor, D.J., Lam, K.H., Stewart, B.D., Parkin, T.D. :
Preliminary genetic analyses of important musculoskeletal conditions of Thoroughbred racehorses in Hong Kong. Vet J 198:611-5, 2013. Pubmed reference: 23746478. DOI: 10.1016/j.tvjl.2013.05.002.
2009 Mählmann, C.h., Steiger, A. :
[Assessment of hereditary defects and dispositions of the horse under animal welfare aspects]. Schweiz Arch Tierheilkd 151:153-8, 2009. Pubmed reference: 19333900. DOI: 10.1024/0036-7281.151.4.153.
Vinardell, T., Dejica, V., Poole, AR., Mort, JS., Richard, H., Laverty, S. :
Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis. Osteoarthritis Cartilage 17:375-83, 2009. Pubmed reference: 18809344. DOI: 10.1016/j.joca.2008.07.017.
2008 Garvican, ER., Vaughan-Thomas, A., Redmond, C., Clegg, PD. :
MT3-MMP (MMP-16) is downregulated by in vitro cytokine stimulation of cartilage, but unaltered in naturally occurring equine osteoarthritis and osteochondrosis. Connect Tissue Res 49:62-7, 2008. Pubmed reference: 18382891. DOI: 10.1080/03008200801913338.
2003 Brommer, H., van, Weeren, P.R., Brama, P.A.J. :
New approach for quantitative assessment of articular cartilage degeneration in horses with osteoarthritis American Journal of Veterinary Research 64:83-87, 2003. Pubmed reference: 12518883.
Clegg, P.D., Mobasheri, A. :
Chondrocyte apoptosis, inflammatory mediators and equine osteoarthritis.[comment] Veterinary Journal 166:3-4, 2003.
Kim, D.Y., Taylor, H.W., Moore, R.M., Paulsen, D.B., Cho, D.Y. :
Articular chondrocyte apoptosis in equine osteoarthritis.[comment] Veterinary Journal 166:52-7, 2003.
2002 Misumi, K., Vilim, V., Hatazoe, T., Murata, T., Fujiki, M., Oka, T., Sakamoto, H., Carter, S.D. :
Serum level of cartilage oligomeric matrix protein (COMP) in equine osteoarthritis Equine Veterinary Journal 34:602-608, 2002. Pubmed reference: 12358001.
2001 Adkins, A.R., Yovich, J.V., Steel, C.M. :
Surgical arthrodesis of distal tarsal joints in 17 horses clinically affected with osteoarthritis Australian Veterinary Journal 79:26-29, 2001. Pubmed reference: 11221565.
2000 Bjornsdottir, S., Arnason, T., Axelsson, M., Eksell, P., Sigurosson, H., Carlsten, J. :
The heritability of degenerative joint disease in the distal tarsal joints in Icelandic horses Livestock Production Science 63:77-83, 2000.
Bjornsdottir, S., Axelsson, M., Eksell, P., Sigurdsson, H., Carlsten, J. :
Radiographic and clinical survey of degenerative joint disease in the distal tarsal joints in Icelandic horses Equine Veterinary Journal 32:268-272, 2000. Pubmed reference: 10836484.
1997 Clegg, P.D., Carter, S.D., Riggs, C.M. :
Osteoarthritis - what hope for effective therapy Equine Veterinary Journal 29:331-332, 1997. Pubmed reference: 9306056.
1996 Jansson, N. :
Equine osteoarthritis - a review of pathogenesis, diagnosis and treatment Pferdeheilkunde 12:111-118, 1996.

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  • Created by Frank Nicholas on 06 Sep 2005