OMIA 000806-9940 : Polyceraty in Ovis aries

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: no

Cross-species summary: Having more horns than the usual two.

Species-specific description: Henson (1961) provided evidence suggesting that the presence of 4 horns is an autosomal recessive trait.

Mapping: In two papers published simultaneously in the same journal, Greyvenstein et al. (2016) and Kijas et al. (2016) confirmed by GWAS that polyceraty is a single-locus trait, and mapped the locus to chromosome OAR2 in the Damara breed and in the Jacob and Navajo-Churro breeds, respectively. These results show that the presence of more than two horns is a separate trait from polled/horns, which maps to chromosome OAR10 (OMIA 000483-9940)

From a GWAS involving "24 two-horned versus 22 four-horned phenotypes in a native Chinese breed of Sishui Fur sheep", followed by LD analysis and haplotype analysis, Ren et al. (2016) narrowed the candidate region to 132.0-133.1 Mb, which includes possible comparative candidate genes "EVX2 and KIAA1715, which have a close association with the formation of limbs and genital buds".

He et al. (2016) reported a similar location (132.6 to 132.7 Mb on chromosome OAR2) for the trait in "three Chinese indigenous breeds: Altay, Mongolian and Sishui Fur sheep".

He et al. (2018): "All three GWAS analyses for typical, atypical . . . and all polycerate phenotypes revealed the same genome‐wide significant SNP marker (rs399639314) at the position of 132.814 Mb on ovine chromosome 2"

Breeds: Damara, Jacob, Navajo-Churro.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 He, X., Song, S., Chen, X., Song, T., Lobsang, T., Guan, W., Pu, Y., Zhao, Q., Jiang, L., Ma, Y. :
Genome-wide association analysis reveals the common genetic locus for both the typical and atypical polycerate phenotype in Tibetan sheep. Anim Genet 49:142-143, 2018. Pubmed reference: 29441598. DOI: 10.1111/age.12644.
2016 Greyvenstein, O.F., Reich, C.M., van Marle-Koster, E., Riley, D.G., Hayes, B.J. :
Polyceraty (multi-horns) in Damara sheep maps to ovine chromosome 2. Anim Genet 47:263-6, 2016. Pubmed reference: 26767563. DOI: 10.1111/age.12411.
He, X., Zhou, Z., Pu, Y., Chen, X., Ma, Y., Jiang, L. :
Mapping the four-horned locus and testing the polled locus in three Chinese sheep breeds. Anim Genet 47:623-7, 2016. Pubmed reference: 27427781. DOI: 10.1111/age.12464.
Kijas, J.W., Hadfield, T., Naval Sanchez, M., Cockett, N. :
Genome-wide association reveals the locus responsible for four-horned ruminant. Anim Genet 47:258-62, 2016. Pubmed reference: 26767438. DOI: 10.1111/age.12409.
Ren, X., Yang, G.L., Peng, W.F., Zhao, Y.X., Zhang, M., Chen, Z.H., Wu, F.A., Kantanen, J., Shen, M., Li, M.H. :
A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries). Sci Rep 6:21111, 2016. Pubmed reference: 26883901. DOI: 10.1038/srep21111.
Ren, X., Yang, G.L., Peng, W.F., Zhao, Y.X., Zhang, M., Chen, Z.H., Wu, F.A., Kantanen, J., Shen, M., Li, M.H. :
Erratum: A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries). Sci Rep 7:25322, 2016. Pubmed reference: 27203473. DOI: 10.1038/srep25322.
1962 Atmadilaga, D., Asikin :
Some observations on the inheritance of polyceraty in the Priangan sheep Communicationes Veterinariae 6:63-68, 1962.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 26 Oct 2011
  • Changed by Frank Nicholas on 21 Jan 2016
  • Changed by Frank Nicholas on 26 Apr 2016
  • Changed by Frank Nicholas on 01 Aug 2016
  • Changed by Frank Nicholas on 23 Mar 2018