OMIA:000807-9689 : Polycystic kidney disease in Panthera leo

In other species: crab-eating macaque , dog , domestic cat , horse , pig , Western roe deer , , sheep , rabbit , degu , markhor , springbok

Categories: Renal / urinary system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 173900 (trait) , 601313 (gene)

Links to MONDO diseases:

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: PKD

Species-specific description: Gerhauser et al. (2009) report "the case of a 19-year-old male lion (Panthera leo) with polycystic lesions in liver and kidney."

(Compiled by Natalia Denisse Ramos Reyes 7/11/2022)

Clinical features: Gerhauser et al. (2009): “The animal suffered from inappetence and progressing hindlimb weakness and was euthanized due to poor prognosis.”

Pathology: Gerhauser et al. (2009): “Necropsy revealed multiple large, cystic cavities in the liver and numerous cysts in the renal cortex. Hepatic and renal cysts were lined by a flattened or cuboidal single-layered epithelium and derived from hepatic bile ducts and renal tubular structures, respectively, as confirmed by immunohistochemistry for the detection of different cytokeratins and carcinoembryonic antigen.”


2009 Gerhauser, I., Philipp, U., Distl, O., Beineke, A. :
Multiple cyst formation in the liver and kidneys of a lion (Panthera leo): a case of polycystic kidney disease? European Journal of Wildlife Research 55:433–437, 2009. DOI:

Edit History

  • Created by Imke Tammen2 on 08 Nov 2022
  • Changed by Imke Tammen2 on 08 Nov 2022