OMIA:000807-9689 : Polycystic kidney disease in Panthera leo |
In other species: crab-eating macaque , dog , domestic cat , horse , pig , Western roe deer , , sheep , rabbit , degu , markhor , springbok
Categories: Renal / urinary system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 173900 (trait) , 601313 (gene)
Links to MONDO diseases:
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: PKD
Species-specific description: Gerhauser et al. (2009) report "the case of a 19-year-old male lion (Panthera leo) with polycystic lesions in liver and kidney."
(Compiled by Natalia Denisse Ramos Reyes 7/11/2022)
Clinical features: Gerhauser et al. (2009): “The animal suffered from inappetence and progressing hindlimb weakness and was euthanized due to poor prognosis.”
Pathology: Gerhauser et al. (2009): “Necropsy revealed multiple large, cystic cavities in the liver and numerous cysts in the renal cortex. Hepatic and renal cysts were lined by a flattened or cuboidal single-layered epithelium and derived from hepatic bile ducts and renal tubular structures, respectively, as confirmed by immunohistochemistry for the detection of different cytokeratins and carcinoembryonic antigen.”
Reference
2009 | Gerhauser, I., Philipp, U., Distl, O., Beineke, A. : |
Multiple cyst formation in the liver and kidneys of a lion (Panthera leo): a case of polycystic kidney disease? European Journal of Wildlife Research 55:433–437, 2009. DOI: https://doi.org/10.1007/s10344-009-0260-9. |
Edit History
- Created by Imke Tammen2 on 08 Nov 2022
- Changed by Imke Tammen2 on 08 Nov 2022