OMIA:000864-9940 : Response to noradrenaline, lack of non-shivering thermogenesis in Ovis aries (sheep)

Categories: Homeostasis / metabolism phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal dominant

Considered a defect: yes

Key variant known: no

Species-specific description: Approximately one-half of the heat produced in response to exposure to low temperatures (cold exposure) arises from non-shivering thermiogenesis, in which exposure to cold stimulates production of endogenous noradrenoline (NA), which in turn stimulates heat production from brown adipose tissue, via the oxidation of free fatty acids derived from the triglycerides in fatty tissue. While investigating the genetic basis of resistance to cold in lambs, Simpson and Slee (1988) measured the extent of non-shivering thermiogenesis in newborn lambs injected subcutaneously with a standard dose of NA. Offspring of one sire failed to show any non-shivering thermiogenesis. Subsequent investigations of planned matings showed that this lack of response to NA is due to a single gene which is most likely dominant.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:000864-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1991 Slee, J., Simpson, S.P. :
Description of the effects of a single gene which inhibits the normal metabolic response of newborn lambs to exogenous noradrenaline. Res Vet Sci 51:34-9, 1991. Pubmed reference: 1896628.
1988 Simpson, S.P., Slee, J. :
The inheritance of non-response to noradrenalin in newborn Scottish Blackface lambs Genetical Research 51:65-69, 1988. Pubmed reference: 3366382.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 21 Oct 2022