OMIA 000961-9940 : Swayback in Ovis aries

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Incoordination progressing to paralysis, blindness and death, associated with a deficiency of copper, which causes dysmyelination of the nerve cells in the brain and spinal cord.

Species-specific description: This disorder is due to a deficiency of copper in the diet. There is substantial genetic variation in ability to withstand a copper deficiency, and hence in resistance to swayback (Wiener, 1966).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1997 Muylle, E. :
Sway back in lambs [Dutch] Vlaams Diergeneeskundig Tijdschrift 66:141, 1997.
1996 Alleyne, T., Adogwa, A., Lalla, A., Joseph, J., John, R. :
Novel mitochondrial proteins and decreased intrinsic activity of cytochrome-c oxidase - characteristics of swayback disease in sheep Molecular & Chemical Neuropathology 28:285-293, 1996.
1972 Kavanagh, P.J., Purcell, D.A., Thompson, R.H. :
Congenital and delayed swayback in lambs in Northern Ireland Veterinary Record 90:538-540, 1972. Pubmed reference: 5073594.
1966 Wiener, G. :
Genetic and other factors in the occurrence of swayback in sheep Journal of Comparative Pathology 76:435-447, 1966. Pubmed reference: 6008381.
Wiener, G., Field, A.C. :
Blood copper levels in sheep in relation to genetic factors, parity and previous swayback history Nature 209:835-836, 1966. Pubmed reference: 5950873.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005