OMIA 000965-9615 : Syringomyelia in Canis lupus familiaris

In other species: domestic cat , cattle , horse , rabbit

Possibly relevant human trait(s) and/or gene(s) (MIM number): 186700 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Mortensen, D., Thoefner, M.S., Agerholm, J.S., Slumstrup, L., Jensen, T.S., Bjerrum, O.J., Berendt, M., Nyengaard, J.R. :
Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching. Pain :, 2022. Pubmed reference: 35353770. DOI: 10.1097/j.pain.0000000000002630.
2021 Mondino, A., Delucchi, L., Moeser, A., Cerdá-González, S., Vanini, G. :
Sleep disorders in dogs: A pathophysiological and clinical review. Top Companion Anim Med 43:100516, 2021. Pubmed reference: 33556640. DOI: 10.1016/j.tcam.2021.100516.
2019 Thoefner, M.S., Westrup, U., Toft, N., Bjerrum, O.J., Berendt, M. :
Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs. Vet J 246:92-97, 2019. Pubmed reference: 30902196. DOI: 10.1016/j.tvjl.2019.01.011.
2018 Ancot, F., Lemay, P., Knowler, S.P., Kennedy, K., Griffiths, S., Cherubini, G.B., Sykes, J., Mandigers, P.J.J., Rouleau, G.A., Rusbridge, C., Kibar, Z. :
A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels. BMC Genet 19:16, 2018. Pubmed reference: 29566674. DOI: 10.1186/s12863-018-0605-z.
2017 Knowler, S.P., Kiviranta, A.M., McFadyen, A.K., Jokinen, T.S., La Ragione, R.M., Rusbridge, C. :
Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation. PLoS One 12:e0169898, 2017. Pubmed reference: 28121988. DOI: 10.1371/journal.pone.0169898.
Wijnrocx, K., Van Bruggen, L.W.L., Eggelmeijer, W., Noorman, E., Jacques, A., Buys, N., Janssens, S., Mandigers, P.J.J. :
Twelve years of chiari-like malformation and syringomyelia scanning in Cavalier King Charles Spaniels in the Netherlands: Towards a more precise phenotype. PLoS One 12:e0184893, 2017. Pubmed reference: 28934242. DOI: 10.1371/journal.pone.0184893.
2015 Thøfner, M.S., Stougaard, C.L., Westrup, U., Madry, A.A., Knudsen, C.S., Berg, H., Jensen, C.S., Handby, R.M., Gredal, H., Fredholm, M., Berendt, M. :
Prevalence and Heritability of Symptomatic Syringomyelia in Cavalier King Charles Spaniels and Long-term Outcome in Symptomatic and Asymptomatic Littermates. J Vet Intern Med 29:243-250, 2015. Pubmed reference: 25308931. DOI: 10.1111/jvim.12475.
Wrzosek, M., Płonek, M., Nicpoń, J., Cizinauskas, S., Pakozdy, A. :
Retrospective multicenter evaluation of the "fly-catching syndrome" in 24 dogs: EEG, BAER, MRI, CSF findings and response to antiepileptic and antidepressant treatment. Epilepsy Behav 53:184-9, 2015. Pubmed reference: 26584225. DOI: 10.1016/j.yebeh.2015.10.013.
2014 Knowler, S.P., McFadyen, A.K., Freeman, C., Kent, M., Platt, S.R., Kibar, Z., Rusbridge, C. :
Quantitative analysis of Chiari-like malformation and syringomyelia in the Griffon Bruxellois dog. PLoS One 9:e88120, 2014. Pubmed reference: 24533070. DOI: 10.1371/journal.pone.0088120.
Mitchell, T.J., Knowler, S.P., van den Berg, H., Sykes, J., Rusbridge, C. :
Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog. Canine Genet Epidemiol 1:9, 2014. Pubmed reference: 26401326. DOI: 10.1186/2052-6687-1-9.
2013 Driver, C.J., Watts, V., Bunck, A.C., Van Ham, L.M., Volk, H.A. :
Assessment of cerebellar pulsation in dogs with and without Chiari-like malformation and syringomyelia using cardiac-gated cine magnetic resonance imaging. Vet J :, 2013. Pubmed reference: 23770398. DOI: 10.1016/j.tvjl.2013.05.017.
Fenn, J., Schmidt, M.J., Simpson, H., Driver, C.J., Volk, H.A. :
Venous sinus volume in the caudal cranial fossa in Cavalier King Charles spaniels with syringomyelia. Vet J :, 2013. Pubmed reference: 23755937. DOI: 10.1016/j.tvjl.2013.05.007.
2011 Knowler, S.P., McFadyen, A.K., Rusbridge, C. :
Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia. Vet Rec :, 2011. Pubmed reference: 21998144. DOI: 10.1136/vr.100062.
Parker, J.E., Knowler, S.P., Rusbridge, C., Noorman, E., Jeffery, N.D. :
Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels. Vet Rec 168:667, 2011. Pubmed reference: 21672954. DOI: 10.1136/vr.d1726.
2010 Lewis, T., Rusbridge, C., Knowler, P., Blott, S., Woolliams, JA. :
Heritability of syringomyelia in Cavalier King Charles spaniels. Vet J 183:345-7, 2010. Pubmed reference: 19914109. DOI: 10.1016/j.tvjl.2009.10.022.
Wolfe, KC., Poma, R. :
Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog. Can Vet J 51:95-102, 2010. Pubmed reference: 20357949.
2009 Carruthers, H., Rusbridge, C., Dubé, M.P., Holmes, M., Jeffery, N. :
Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 50:394-8, 2009. Pubmed reference: 19689666. DOI: 10.1111/j.1748-5827.2009.00768.x.
Cerda-Gonzalez, S., Olby, NJ., Broadstone, R., McCullough, S., Osborne, JA. :
Characteristics of cerebrospinal fluid flow in Cavalier King Charles Spaniels analyzed using phase velocity cine magnetic resonance imaging. Vet Radiol Ultrasound 50:467-76, 2009. Pubmed reference: 19788029.
Mandigers, P., Rusbridge, C. :
[Chiari-like malformation--syringomyelia in the Cavalier King Charles Spaniel] Tijdschr Diergeneeskd 134:746-50, 2009. Pubmed reference: 19911737.
Park, C., Kang, BT., Yoo, JH., Park, HM. :
Syringomyelia in three small breed dogs secondary to Chiari-like malformation: clinical and diagnostic findings. J Vet Sci 10:365-7, 2009. Pubmed reference: 19934606.
Rusbridge, C., Knowler, SP., Pieterse, L., McFadyen, AK. :
Chiari-like malformation in the Griffon Bruxellois. J Small Anim Pract 50:386-93, 2009. Pubmed reference: 19689665. DOI: 10.1111/j.1748-5827.2009.00744.x.
2008 Chandler, K., Volk, H., Rusbridge, C., Jeffery, N. :
Syringomyelia in cavalier King Charles spaniels. Vet Rec 162:324, 2008. Pubmed reference: 18326849.
Kitagawa, M., Ueno, H., Watanabe, S., Igarashi, O., Uzuka, Y., Kanayama, K., Sakai, T. :
Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J 86:36-42, 2008. Pubmed reference: 18271823. DOI: 10.1111/j.1751-0813.2007.00247.x.
Rusbridge, C., Jeffery, ND. :
Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J 175:164-72, 2008. Pubmed reference: 17317245. DOI: 10.1016/j.tvjl.2006.12.007.
Stalin, CE., Rusbridge, C., Granger, N., Jeffery, ND. :
Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res 69:89-93, 2008. Pubmed reference: 18167092. DOI: 10.2460/ajvr.69.1.89.
2007 Rusbridge, C., Carruthers, H., Dubé, M.P., Holmes, M., Jeffery, N.D. :
Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract 48:432-6, 2007. Pubmed reference: 17608656. DOI: 10.1111/j.1748-5827.2007.00344.x.
2006 Jung, DI., Park, C., Kang, BT., Kim, JW., Kim, HJ., Lim, CY., Jeong, SW., Park, HM. :
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci 68:1235-8, 2006. Pubmed reference: 17146188.
MacKillop, E., Schatzberg, SJ., de Lahunta, A. :
Intracranial epidermoid cyst and syringohydromyelia in a dog. Vet Radiol Ultrasound 47:339-44, 2006. Pubmed reference: 16863050.
Rusbridge, C., Knowler, SP. :
Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 47:603-6, 2006. Pubmed reference: 17004953. DOI: 10.1111/j.1748-5827.2006.00048.x.
Rusbridge, C., Greitz, D., Iskandar, BJ. :
Syringomyelia: current concepts in pathogenesis, diagnosis, and treatment. J Vet Intern Med 20:469-79, 2006. Pubmed reference: 16734077.
2005 Hasegawa, T., Taura, Y., Kido, H., Shibazaki, A., Katamoto, H. :
Surgical management of combined hydrocephalus, syringohydromyelia, and ventricular cyst in a dog. J Am Anim Hosp Assoc 41:267-72, 2005. Pubmed reference: 15995165.
Rusbridge, C., Knowler, P., Rouleau, GA., Minassian, BA., Rothuizen, J. :
Inherited occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel: experiences in setting up a worldwide DNA collection. J Hered 96:745-9, 2005. Pubmed reference: 15958797. DOI: 10.1093/jhered/esi074.
Takagi, S., Kadosawa, T., Ohsaki, T., Hoshino, Y., Okumura, M., Fujinaga, T. :
Hindbrain decompression in a dog with scoliosis associated with syringomyelia. J Am Vet Med Assoc 226:1359-63, 1347, 2005. Pubmed reference: 15844429.
2004 Rusbridge, C., Knowler, SP. :
Inheritance of occipital bone hypoplasia (Chiari type I malformation) in Cavalier King Charles Spaniels. J Vet Intern Med 18:673-8, 2004. Pubmed reference: 15515584.
2000 Bagley, R.S., Gavin, P.R., Silver, G.M., Moore, M.P., Kippenes, H., Connors, R. :
Syringomyelia and hydromyelia in dogs and cats Compendium on Continuing Education for the Practicing Veterinarian 22:471-479, 2000.
Rusbridge, C., MacSweeny, J.E., Davies, J.V., Chandler, K., Fitzmaurice, S.N., Dennis, R., Cappello, R., Wheeler, S.J. :
Syringohydromyelia in Cavalier King Charles spaniels Journal of the American Animal Hospital Association 36:34-41, 2000. Pubmed reference: 10667404.
Taga, A., Taura, Y., Nakaichi, M., Wada, N., Hasegawa, T. :
Magnetic resonance imaging of syringomyelia in five dogs Journal of Small Animal Practice 41:362-365, 2000. Pubmed reference: 11002940.
1996 Itoh, T., Nishimura, R., Matsunaga, S., Kodosawa, T., Mochizuki, M., Sasaki, N. :
Syringomyelia and hydrocephalus in a dog Journal of the American Veterinary Medical Association 209:934 ff., 1996.
1973 Furneaux, R.W., Doige, C.E., Kaye, M.M. :
Syringomyelia and spina bifida occulta in a Samoyed dog. Can Vet J 14:317-21, 1973. Pubmed reference: 4588835.
1965 McGrath, J.T. :
Spinal dysraphism in the dog, with comments on syringomylia Pathologia Veterinaria 2:1-36 (Supplement), 1965. Pubmed reference: 5893238.

Edit History

  • Created by Frank Nicholas on 25 Oct 2010
  • Changed by Imke Tammen2 on 27 Aug 2021