OMIA:000977-314295 : Taillessness in Hominoidea (apes)

In other species: dog , pig , taurine cattle , sheep

Categories: Limbs / fins / digit / tail phene

Single-gene trait/disorder: unknown

Disease-related: no

Cross-species summary: Absence of the tail. Also called anury.

Molecular basis: Xia et al. (2024) "present evidence that an individual insertion of an Alu element in the genome of the hominoid ancestor may have contributed to tail-loss evolution. [The authors] demonstrate that this Alu element—inserted into an intron of the TBXT gene pairs with a neighbouring ancestral Alu element encoded in the reverse genomic orientation and leads to a hominoid-specific alternative splicing event."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000977-314295: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2024 Xia, B., Zhang, W., Zhao, G., Zhang, X., Bai, J., Brosh, R., Wudzinska, A., Huang, E., Ashe, H., Ellis, G., Pour, M., Zhao, Y., Coelho, C., Zhu, Y., Miller, A., Dasen, J.S., Maurano, M.T., Kim, S.Y., Boeke, J.D., Yanai, I. :
On the genetic basis of tail-loss evolution in humans and apes. Nature 626:1042-1048, 2024. Pubmed reference: 38418917. DOI: 10.1038/s41586-024-07095-8.

Edit History


  • Created by Imke Tammen2 on 04 Mar 2024
  • Changed by Imke Tammen2 on 04 Mar 2024