OMIA:000977-314295 : Taillessness in Hominoidea (apes) |
In other species: dog , pig , taurine cattle , sheep
Categories: Limbs / fins / digit / tail phene
Single-gene trait/disorder: unknown
Disease-related: no
Cross-species summary: Absence of the tail. Also called anury.
Molecular basis: Xia et al. (2024) "present evidence that an individual insertion of an Alu element in the genome of the hominoid ancestor may have contributed to tail-loss evolution. [The authors] demonstrate that this Alu element—inserted into an intron of the TBXT gene pairs with a neighbouring ancestral Alu element encoded in the reverse genomic orientation and leads to a hominoid-specific alternative splicing event."
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000977-314295: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2024 | Xia, B., Zhang, W., Zhao, G., Zhang, X., Bai, J., Brosh, R., Wudzinska, A., Huang, E., Ashe, H., Ellis, G., Pour, M., Zhao, Y., Coelho, C., Zhu, Y., Miller, A., Dasen, J.S., Maurano, M.T., Kim, S.Y., Boeke, J.D., Yanai, I. : |
On the genetic basis of tail-loss evolution in humans and apes. Nature 626:1042-1048, 2024. Pubmed reference: 38418917. DOI: 10.1038/s41586-024-07095-8. |
Edit History
- Created by Imke Tammen2 on 04 Mar 2024
- Changed by Imke Tammen2 on 04 Mar 2024