OMIA 000978-9031 : Talpid-2 in Gallus gallus

Category: Limbs / digit / tail phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Clinical features: "Homozygotes (-/-) display extreme preaxial polydactly, exposed viscera, cleft palate, parrot-like beak, and dwarfing with greatly reduced leg and wing proximal bones in addition to the duplication of the distal digit bones" (Robb et al., 2011)


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year. > > > > > > > > > > > >
2016 Schock, E.N., Chang, C.F., Youngworth, I.A., Davey, M.G., Delany, M.E., Brugmann, S.A. :
Utilizing the chicken as an animal model for human craniofacial ciliopathies. Dev Biol 415:326-337, 2016. Pubmed reference: 26597494. DOI: 10.1016/j.ydbio.2015.10.024.
2011 Robb, EA., Gitter, CL., Cheng, HH., Delany, ME. :
Chromosomal mapping and candidate gene discovery of chicken developmental mutants and genome-wide variation analysis of MHC congenics. J Hered 102:141-56, 2011. Pubmed reference: 21273214. DOI: 10.1093/jhered/esq122.
2006 Harris, MP., Hasso, SM., Ferguson, MW., Fallon, JF. :
The development of archosaurian first-generation teeth in a chicken mutant. Curr Biol 16:371-7, 2006. Pubmed reference: 16488870. DOI: 10.1016/j.cub.2005.12.047.
2005 Vargas, AO., Fallon, JF. :
Birds have dinosaur wings: The molecular evidence. J Exp Zoolog B Mol Dev Evol 304:86-90, 2005. Pubmed reference: 15880773. DOI: 10.1002/jez.b.21042.
1999 Caruccio, N.C., Martinez-Lopez, A., Harris, M., Dvorak, L., Bitgood, J., Simandl, B.K., Fallon, J.F. :
Constitutive activation of sonic hedgehog signaling in the chicken mutant talpid(2): Shh-independent outgrowth and polarizing activity. Dev Biol 212:137-49, 1999. Pubmed reference: 10419691. DOI: 10.1006/dbio.1999.9321.
1996 Rodriguez, C., Kos, R., Macias, D., Abbott, U.K., Belmonte, J.C.I. :
Shh, hoxd, BMP-2, and FGF-4 gene expression during development of the polydactylous Talpid(2), Diplopodia(1), and Diplopodia(4) mutant chick limb buds Developmental Genetics 19:26-32, 1996. Pubmed reference: 8792606. DOI: 10.1002/(SICI)1520-6408(1996)19:1<26::AID-DVG3>3.0.CO;2-2.
1992 Coelho, C.N.D., Upholt, W.B., Kosher, R.A. :
Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds Development 115:629-637, 1992. Pubmed reference: 1358596.
1991 Dvorak, L., Fallon, J.F. :
Talpid2 Mutant Chick Limb Has Anteroposterior Polarity and Altered Patterns of Programmed Cell Death Anatomical Record 231:251-260, 1991. Pubmed reference: 1746725. DOI: 10.1002/ar.1092310213.
1980 Perle, M.A., Newman, S.A. :
Talpid2 mutant of the chicken with perturbed cartilage development has an altered precartilage-specific chromatin protein. Proc Natl Acad Sci U S A 77:4828-30, 1980. Pubmed reference: 6933534.
1974 MacCabe, J.A., Abbott, U.K. :
Polarizing and maintenance activities in 2 polydactylous mutants of fowl: diplopodia-1 and talpid-2 Journal of Embryology and Experimental Morphology 31:735-746, 1974.
1964 Goetinck, P.F., Abbott, U.K. :
Studies on limb morphogenesis. I. Experiments with the polydactylous mutant, talpid2 Journal of Experimental Zoology 155:161-170, 1964. Pubmed reference: 14131452.
1959 Abbott, U.K., Taylor, L.W., Abplanalp, H. :
A second talpid-like mutation in the fowl Poultry Science 38:1185-1262, 1959.

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  • Created by Frank Nicholas on 26 Feb 2011