OMIA:000994-9615 : Tetralogy of Fallot in Canis lupus familiaris (dog)

In other species: domestic cat , horse , taurine cattle , goat , snow leopard

Categories: Cardiovascular system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 187500 (trait) , 187501 (trait) , 239711 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific description: see conotruncal heart malformations in the dog

Breed: Keeshond (Dog) (VBO_0200759).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2011). OMIA:000994-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Malcolm, E.L., Saunders, A.B. :
Complex tetralogy of Fallot in an acyanotic adult dog. CASE (Phila) 8:231-235, 2024. Pubmed reference: 38524971. DOI: 10.1016/
2016 Chetboul, V., Pitsch, I., Tissier, R., Gouni, V., Misbach, C., Trehiou-Sechi, E., Petit, A.M., Damoiseaux, C., Pouchelon, J.L., Desquilbet, L., Bomassi, E. :
Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc 249:909-917, 2016. Pubmed reference: 27700266. DOI: 10.2460/javma.249.8.909.
2009 Lee, JS., Hyun, C. :
Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). J Anim Breed Genet 126:304-10, 2009. Pubmed reference: 19630881. DOI: 10.1111/j.1439-0388.2008.00776.x.
2001 Orton, E.C., Mama, K., Hellyer, P., Hackett, T.B. :
Open surgical repair of tetralogy of Fallot in dogs Journal of the American Veterinary Medical Association 219:1089-+, 2001. Pubmed reference: 11700706.
1999 Oguchi, Y., Matsumoto, H., Masuda, Y., Takashima, H., Takashima, K., Yamane, Y. :
Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot Journal of Veterinary Medical Science 61:1067-1069, 1999. Pubmed reference: 10535516.
1998 Lew, L.J., Fowler, J.D., Mckay, R., Egger, C.M., Rosin, M.W. :
Open-heart correction of tetralogy of fallot in an acyanotic dog Journal of the American Veterinary Medical Association 213:652 ff., 1998.
1997 Tidholm, A. :
Retrospective study of congenital heart defects in 151 dogs Journal of Small Animal Practice 38:94-98, 1997. Pubmed reference: 9097239.
1995 Weber, U.T., Carrel, T., Lang, J., Lombard, G.W. :
Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German] Schweizer Archiv fur Tierheilkunde 137:480-484, 1995. Pubmed reference: 7494990.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Vicki Meyers-Wallen on 28 Sep 2011