OMIA 001001-9615 : Thrombocytopenia in Canis lupus familiaris

In other species: domestic cat , horse , cattle

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 155100 (trait) , 141000 (trait) , 188000 (trait) , 188020 (trait) , 188025 (trait) , 188030 (trait) , 273900 (trait) , 274000 (trait) , 313900 (trait) , 613112 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Includes macrothrombocytopenia

Species-specific description: See OMIA 002434-9615 : Thrombocytopenia, TUBB1-related in Canis lupus familiaris for this disease in Cavalier King Charles Spaniels and Norfolk and Cairn Terriers

Clinical features: This disorder occurs in many different forms, many of which are not inherited. As summarised by Żmigrodzka et al. (2014), "Thrombocytopenia (low platelet count) can occur as a result of a megacaryocyte disorder, disturbance of platelet production as well as their premature destruction. Platelet count can be also decreased due to sequestration of platelets in the tissues . . . . Myeloproliferative bone marrow disorders as well as certain drugs (e.g. oestrogens and chloramphenicol) can alter platelet production in the bone marrow . . . . The most frequent cause of thrombocytopenia is premature platelet destruction due to an abnormal immune response; when no underlying disease is found and aetiological agent remains undetermined IMT is described as primary. Secondary disease can develop in neoplastic conditions (e.g. mammary gland tumour, haemangiosarcoma, and lymphoma), infectious diseases (e.g. babesiosis, leptospirosis, and other bacterial, viral, and parasitic infections), after vaccination with live attenuated viruses (e.g. canine distemper virus), or after drug treatment (e.g. chloramphenicol, cephalosporin, sulphonamides, and gold salts). Rapid platelet consumption is often observed in acute haemorrhage, disseminated intravascular coagulation, or inflammation. Destruction and consumption of platelets are also enhanced in microangiopathies . . . . Common causes of platelet sequestration are splenomegaly, splenic torsion, and sepsis . . . ."

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Cooper, S.A., Huang, A.A., Raskin, R.E., Weng, H.Y., Scott-Moncrieff, J.C. :
Clinical data, clinicopathologic findings and outcome in dogs with amegakaryocytic thrombocytopenia and primary immune-mediated thrombocytopenia. J Small Anim Pract 57:142-7, 2016. Pubmed reference: 26799165. DOI: 10.1111/jsap.12441.
2014 Schwartz, D., Sharkey, L., Armstrong, P.J., Knudson, C., Kelley, J. :
Platelet volume and plateletcrit in dogs with presumed primary immune-mediated thrombocytopenia. J Vet Intern Med 28:1575-9, 2014. Pubmed reference: 25056453. DOI: 10.1111/jvim.12405.
Zmigrodzka, M., Guzera, M., Winnicka, A. :
Evaluation of reticulated platelets in dogs with breed-related thrombocytopenia. Pol J Vet Sci 17:137-42, 2014. Pubmed reference: 24724481.
2013 Collicutt, N.B., Garner, B. :
Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate. Vet Clin Pathol 42:458-64, 2013. Pubmed reference: 24138476. DOI: 10.1111/vcp.12089.
2011 Bodié, K., Gagne, G.D., Sramek, M.K., Desmond, D.J., Abel, S.J., Fagerland, J.A. :
Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: a case report. Toxicol Pathol 39:980-7, 2011. Pubmed reference: 21859886. DOI: 10.1177/0192623311416261.
2009 Botsch, V., Küchenhoff, H., Hartmann, K., Hirschberger, J. :
Retrospective study of 871 dogs with thrombocytopenia. Vet Rec 164:647-51, 2009. Pubmed reference: 19465753.
Shelah-Goraly, M., Aroch, I., Kass, P.H., Bruchim, Y., Ofri, R. :
A prospective study of the association of anemia and thrombocytopenia with ocular lesions in dogs. Vet J 182:187-92, 2009. Pubmed reference: 18664411. DOI: 10.1016/j.tvjl.2008.05.027.
2008 Bommer, N.X., Shaw, D.J., Milne, E.M., Ridyard, A.E. :
Platelet distribution width and mean platelet volume in the interpretation of thrombocytopenia in dogs. J Small Anim Pract 49:518-24, 2008. Pubmed reference: 18793252. DOI: 10.1111/j.1748-5827.2008.00636.x.
Putsche, J.C., Kohn, B. :
Primary immune-mediated thrombocytopenia in 30 dogs (1997-2003). J Am Anim Hosp Assoc 44:250-7, 2008. Pubmed reference: 18762561. DOI: 10.5326/0440250.
2005 Middleton, SM. :
Immune-mediated thrombocytopenia in a 4-month-old German shepherd dog. Can Vet J 46:443-5, 2005. Pubmed reference: 16018567.
2004 Olsen, L.H., Kristensen, A.T., Qvortrup, K., Pedersen, H.D. :
Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia. J Vet Diagn Invest 16:167-70, 2004. Pubmed reference: 15053372.
2002 Rozanski, E.A., Callan, M.B., Hughes, D., Sanders, N., Giger, U. :
Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs Journal of the American Veterinary Medical Association 220:477-481, 2002. Pubmed reference: 11860242.
2000 LeGrange, S.N., Fossum, T.W., Lemire, T., Storts, R.W., Thomas, J.S. :
Thrombosis of the caudal vena cava presenting as an unusual cause of an abdominal mass and thrombocytopenia in a dog Journal of the American Animal Hospital Association 36:143-151, 2000. Pubmed reference: 10730625.
1998 Mischke, R., Adamik, A. :
Sensitivity of resonance thrombography in thrombocytopenia in dogs [German] Berliner und Munchener Tierarztliche Wochenschrift 111:302-305, 1998. Pubmed reference: 9741188.
1995 Mackin, A. :
Canine immune-mediated thrombocytopenia .1. Compendium on Continuing Education for the Practicing Veterinarian 17:353, 1995.
Mackin, A. :
Canine immune-mediated thrombocytopenia .3. Compendium on Continuing Education for the Practicing Veterinarian 17:515, 1995.
1994 Kristensen, A.T., Weiss, D.J., Klausner, J.S., Laber, J., Christie, D.J. :
Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of having immune-mediated thrombocytopenia American Journal of Veterinary Research 55:1111-1114, 1994. Pubmed reference: 7978651.

Edit History


  • Created by Frank Nicholas on 03 Nov 2010
  • Changed by Frank Nicholas on 29 Sep 2011
  • Changed by Frank Nicholas on 18 Feb 2012
  • Changed by Frank Nicholas on 15 Sep 2014
  • Changed by Frank Nicholas on 22 Apr 2016
  • Changed by Imke Tammen2 on 26 Sep 2021