OMIA 001056-9615 : Von Willebrand disease, generic in Canis lupus familiaris

In other species: cattle , horse , pig , rabbit , domestic cat

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 177820 , 193400 , 231200 , 277480 , 314560

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Markers: y


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Keeshen, T.P., Case, J.B., Runge, J.J., Singh, A., Mayhew, P.D., Steffey, M.A., Culp, W.T.N. :
Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012-2014). J Am Vet Med Assoc 251:1053-1058, 2017. Pubmed reference: 29035661. DOI: 10.2460/javma.251.9.1053.
2009 Nichols, TC., Dillow, AM., Franck, HW., Merricks, EP., Raymer, RA., Bellinger, DA., Arruda, VR., High, KA. :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J 50:144-67, 2009. Pubmed reference: 19293459.
2005 Heseltine, JC., Panciera, DL., Troy, GC., Monroe, WE., Brooks, MB., Feldman, BF. :
Effect of levothyroxine administration on hemostatic analytes in Doberman Pinschers with von Willebrand disease. J Vet Intern Med 19:523-7, 2005. Pubmed reference: 16095169.
2000 Lobetti, R.G., Dippenaar, T. :
Von Willebrand's disease in the German shepherd dog Journal of the South African Veterinary Medical Association 71:118-121, 2000.
1999 Applewhite, A.A., Wilkens, B.E., McDonald, D.E., Radasch, R.M., Barstad, R.D. :
Potential central nervous system complications of von Willebrand's disease Journal of the American Animal Hospital Association 35:423-429, 1999. Pubmed reference: 10493419.
Brooks, M. :
Hereditary bleeding disorders in dogs and cats Veterinary Medicine 94:555-564, 1999.
Schwarz, H.P., Dorner, F., Mitterer, A., Mundt, W., Schlokat, U., Pichler, L., Turecek, P.L. :
Preclinical evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Wiener Klinische Wochenschrift 111:181-191, 1999. Pubmed reference: 10226348.
Venta, P.J., Vidal, M. :
MspI RSP in exon 42 of the canine von Willebrand factor (VWF) gene Animal Genetics 30:229, 1999. Pubmed reference: 10442993.
1998 Brewer, G.J. :
Von Willebrand disease DNA testing Canine Practice 23:27-28, 1998.
Degopegui, R.R., Feldman, B.F. :
Acquired and inherited platelet dysfunction in small animals Compendium on Continuing Education for the Practicing Veterinarian 20:1039 ff., 1998.
Ray, J., Brooks, M.B., Suh, Y., Ray, K. :
A PCR-RFLP marker in canine von willebrand factor gene (vwf) Animal Genetics 29:406-407, 1998. Pubmed reference: 9800340.
Schwarz, H.P., Dorner, F., Mitterer, A., Mundt, W., Schlokat, U., Pichler, L., Turecek, P.L. :
Evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Haemophilia 4:53-62, 1998. Pubmed reference: 10028320.
1997 Arnold, S., Muller, A., Binder, H., Meyers, K., Giger, U. :
Plasma von-willebrand-factor concentrations in bernese mountain dogs [German] Schweizer Archiv fur Tierheilkunde 139:177-182, 1997. Pubmed reference: 9173518.
Stokol, T., Trepanier, L., Parry, B.W., Finnin, B.C. :
Pharmacokinetics of von Willebrand factor and factor VIII in canine von-Willebrand-disease and haemophilia A Research in Veterinary Science 63:23-27, 1997. Pubmed reference: 9368952.
Turecek, P.L., Gritsch, H., Pichler, L., Auer, W., Fischer, B., Mitterer, A., Mundt, W., Schlokat, U., Dorner, F., Erinkman, H.J.M., Vanmourik, J.A., Schwarz, H.P. :
In vivo characterization of recombinant von willebrand factor in dogs with von-willebrand-disease Blood 90:3555-3567, 1997. Pubmed reference: 9345039.
1996 Anon. :
Test identifies carriers of von Willebrands disease American Journal of Veterinary Research 57:1521, 1996.
Brooks, M., Raymond, S., Catalfamo, J. :
Plasma von Willebrand factor antigen concentration as a predictor of von Willebrands disease status in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:930 ff., 1996.
Brooks, M., Raymond, S., Catalfamo, J. :
Severe, recessive von Willebrands disease in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:926 ff., 1996.
Holmes, N.G., Shaw, S.C., Dickens, H.F., Coombes, L.M., Ryder, E.J., Littlewood, J.D., Binns, M.M. :
Von willebrands disease in UK Dobermanns - possible correlation of a polymorphic DNA marker with disease status Journal of Small Animal Practice 37:307-308, 1996. Pubmed reference: 8840249.
Moser, J., Meyers, K.M., Meinkoth, J.H., Brassard, J.A. :
Temporal variation and factors affecting measurement of canine von willebrand factor American Journal of Veterinary Research 57:1288-1293, 1996. Pubmed reference: 8874720.
Moser, J., Meyers, K.M., Russon, R.H. :
Inheritance of von willebrand factor deficiency in doberman pinschers Journal of the American Veterinary Medical Association 209:1103 ff., 1996.
Thomas, J.S. :
von Willebrand's disease in the dog and cat. Vet Clin North Am Small Anim Pract 26:1089-110, 1996. Pubmed reference: 8863392.
Thomas, J.S. :
Von Willebrand's disease in the dog and cat Veterinary Clinics of North America - Small Animal Practice 26:1089 ff., 1996.
1995 Clark, P., Parry, B.W. :
Survey of Irish Wolfhounds in Australia for von Willebrands disease Australian Veterinary Journal 72:393, 1995. Pubmed reference: 8599574.
Dunn, K.J., Nicholls, P.K., Dunn, J.K., Herrtage, M.E. :
Intracranial haemorrhage in a dobermann puppy with von Willebrand's disease Veterinary Record 136:635-636, 1995. Pubmed reference: 7571271.
Slappendel, R.J. :
Von Willebrand's disease in Dutch Kooiker dogs Veterinary Quarterly 17:S21-S22, 1995. Pubmed reference: 7571294.
Stokol, T., Parry, B.W. :
Stability of canine factor VIII and von Willebrand factor antigen concentration in the frozen state Research in Veterinary Science 59:156-159, 1995. Pubmed reference: 8525106.
Stokol, T., Parry, B.W. :
Stability of von Willebrand factor and factor VIII in canine cryoprecipitate under various conditions of storage Research in Veterinary Science 59:152-155, 1995. Pubmed reference: 8525105.
Stokol, T., Parry, B.W., Mansell, P.D. :
Von willebrands disease in scottish terriers in australia Australian Veterinary Journal 72:404-407, 1995. Pubmed reference: 8929184.
Stokol, T., Parry, B.W., Mansell, P.D. :
von Willebrand's disease in Dobermann dogs in Australia Australian Veterinary Journal 72:257-262, 1995. Pubmed reference: 8534229.
1994 Brassard, J.A., Meyers, K.M. :
von Willebrand factor is not altered in azotemic dogs with prolonged bleeding time Journal of Laboratory and Clinical Medicine 124:55-62, 1994. Pubmed reference: 8035104.
Ching, Y.N.L.H., Meyers, K.M., Brassard, J.A., Wardrop, K.J. :
Effect of Cryoprecipitate and Plasma on Plasma Vonwillebrand Factor Multimeters and Bleeding Time in Doberman-Pinschers with Type-I Vonwillebrands Disease American Journal of Veterinary Research 55:102-110, 1994. Pubmed reference: 8141483.
Locke, K. :
Severe Haemorrhage in Dobermann Dogs with Vonwillebrand's Disease and Its Control During Surgery Australian Veterinary Journal 71:263, 1994. Pubmed reference: 7986192.
1993 Nichols, T.C., Bellinger, D.A., Reddick, R.L., Smith, S.V., Koch, G.G., Davis, K., Sigman, J., Brinkhous, K.M., Griggs, T.R., Read, M.S. :
The Roles of von Willebrand Factor and Factor-VIII in Arterial Thrombosis - Studies in Canine von Willebrand Disease and Hemophilia-A Blood 81:2644-2651, 1993. Pubmed reference: 8490173.
Stokol, T., Parry, B.W. :
Canine Vonwillebrand Disease - A Review Australian Veterinary Practitioner 23:94-103, 1993.
1992 Benson, R.E., Catalfamo, J.L., Dodds, W.J. :
A Multispecies Enzyme-Linked Immunosorbent Assay for Von Willebrand's Factor Journal of Laboratory and Clinical Medicine 119:420-427, 1992. Pubmed reference: 1583394.
Brooks, M. :
Management of canine von Willebrand's disease. Probl Vet Med 4:636-46, 1992. Pubmed reference: 1472774.
Brooks, M., Dodds, W.J., Raymond, S.L. :
Epidemiologic Features of von Willebrand's Disease in Doberman-Pinschers, Scottish Terriers, and Shetland Sheepdogs - 260 Cases (1984-1988) Journal of the American Veterinary Medical Association 200:1123-1127, 1992. Pubmed reference: 1607320.
Huss, B.T., Ettinger, S.J. :
Visceral Leishmaniasis, Rocky Mountain Spotted Fever, and Vonwillebrand's Disease in a Giant Schnauzer Journal of the American Animal Hospital Association 28:221-225, 1992.
Mansell, P.D., Parry, B.W. :
Effect of Acepromazine, Xylazine and Thiopentone on Factor VIII Activity and Vonwillebrand Factor Antigen Concentration in Dogs Australian Veterinary Journal 69:187-190, 1992. Pubmed reference: 1530553.
Mansell, P.D., Parry, B.W. :
Changes in Factor 8 Activity and Vonwillebrand-Factor Antigen Concentration with Age in Dogs British Veterinary Journal 148:329-337, 1992. Pubmed reference: 1498645. DOI: 10.1016/0007-1935(92)90085-F.
Meyers, K.M., Wardrop, K.J., Meinkoth, J. :
Canine von Willebrand's Disease - Pathobiology, Diagnosis, and Short-Term Treatment Compendium on Continuing Education for the Practicing Veterinarian 14:13, 1992.
Slappendel, R.J., Frielink, R.A.J., Mol, J.A., Noordzij, A., Hamer, R. :
An Enzyme-Linked Immunosorbent Assay (ELISA) for Vonwillebrand Factor Antigen (vWf-Ag) in Canine Plasma Veterinary Immunology and Immunopathology 33:145-154, 1992. Pubmed reference: 1632075.
1991 Benson, R.E., Catalfamo, J.L., Brooks, M., Dodds, W.J. :
A Sensitive Immunoassay for von Willebrand Factor Journal of Immunoassay 12:371-390, 1991. Pubmed reference: 1939665. DOI: 10.1080/01971529108055078.
Brassard, J.A., Meyers, K.M. :
Evaluation of the Buccal Bleeding Time and Platelet Glass Bead Retention As Assays of Hemostasis in the Dog - The Effects of Acetylsalicylic Acid, Warfarin and Vonwillebrand Factor Deficiency Thrombosis and Haemostasis 65:191-195, 1991. Pubmed reference: 2053106.
Brinkhous, K.M., Reddick, R.L., Read, M.S., Nichols, T.C., Bellinger, D.A., Griggs, T.R. :
von Willebrand Factor and Animal Models - Contributions to Gene Therapy, Thrombotic Thrombocytopenic Purpura, and Coronary Artery Thrombosis Mayo Clinic Proceedings 66:733-742, 1991. Pubmed reference: 2072761.
Johnstone, I.B., Crane, S. :
Quantitation of Canine Plasma Von Willebrand Factor Antigen Using a Commercial Enzyme-Linked Immunosorbent Assay Canadian Journal of Veterinary Research-Revue Canadienne de Recherche Veterinaire 55:11-14, 1991. Pubmed reference: 1884278.
Johnstone, I.B., Keen, J., Halbert, A., Crane, S. :
Stability of Factor-VIII and Vonwillebrand Factor in Canine Blood Samples During Storage Canadian Veterinary Journal-Revue Veterinaire Canadienne 32:173-175, 1991.
Mansell, P.D., Parry, B.W. :
Stability of Canine Factor-VIII Activity and Vonwillebrand Factor Antigen Concentration Invitro Research in Veterinary Science 51:313-316, 1991. Pubmed reference: 1780587.
Parker, M.T., Turrentine, M.A., Johnson, G.S. :
Von Willebrand Factor in Lysates of Washed Canine Platelets American Journal of Veterinary Research 52:119-125, 1991. Pubmed reference: 2021239.
1990 Avgeris, S., Lothrop, C.D., Mcdonald, T.P. :
Plasma Vonwillebrand Factor Concentration and Thyroid Function in Dogs Journal of the American Veterinary Medical Association 196:921-924, 1990. Pubmed reference: 2107158.
Dueland, R.T., Wagner, S.D., Parker, R.B. :
Vonwillebrand Heterotopic Osteochondrofibrosis in Doberman Pinschers - 5 Cases (1980-1987) Journal of the American Veterinary Medical Association 197:383-388, 1990. Pubmed reference: 2118129.
Meyers, K.M., Wardrop, K.J., Dodds, W.J., Brassard, J. :
Effect of Exercise, Ddavp, and Epinephrine on the Factor VIII- C Vonwillebrand Factor Complex in Normal Dogs and Vonwillebrand Factor Deficient Doberman-Pinscher Dogs Thrombosis Research 57:97-108, 1990. Pubmed reference: 2105540.
Meyers, K.M., Wardrop, K.J., Helmick, C., White, F. :
Vonwillebrand Factor Is Present in the Vascular Endothelium from Normal Dogs and from Doberman-Pinscher Dogs with a Plasma Vonwillebrand Factor Deficiency Thrombosis Research 57:109-116, 1990. Pubmed reference: 2405539.
Raymond, S.L., Jones, D.W., Brooks, M.B., Dodds, W.J. :
Clinical and Laboratory Features of a Severe Form of Vonwillebrand Disease in Shetland Sheepdogs Journal of the American Veterinary Medical Association 197:1342-1346, 1990. Pubmed reference: 2266049.
1989 Brinkhous, K.M., Hedner, U., Garris, J.B., Diness, V., Read, M.S. :
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A 86:1382-6, 1989. Pubmed reference: 2784006.
1988 Johnson, G.S., Turrentine, M.A., Kraus, K.H. :
Canine von Willebrand's disease. A heterogeneous group of bleeding disorders Veterinary Clinics of North America, Small Animal Practice 18:195-229, 1988.
1986 Randolph, J.F., Center, S.A., Dodds, W.J. :
Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs. Cornell Vet 76:3-10, 1986. Pubmed reference: 3484442.
1981 Johnstone, I.B., Crane, S. :
Von Willebrand's disease in two families of Doberman Pinschers Canadian Veterinary Journal 22:239-243, 1981.
1978 Read, M.S., Shermer, R.W., Brinkhous, K.M. :
Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Proc Natl Acad Sci U S A 75:4514-8, 1978. Pubmed reference: 309134.
1977 Dodds, W.J. :
Porcine and canine von Willebrand's disease Comparative Pathology Bulletin 9:2-, 1977.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005