OMIA:001056-9615 : Von Willebrand disease, generic in Canis lupus familiaris (dog)

In other species: domestic cat , horse , pig , taurine cattle , rabbit

Categories: Haematopoietic system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 177820 (trait) , 193400 (trait) , 231200 (trait) , 277480 (trait) , 314560 (trait) , 613160 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Cross-species summary: The von Willebrand factor (vWF) is a large multimeric plasma glycoprotein required for platelet adhesion and aggregation. A deficiency or defective vWF results in von Willebrand disease (vWD). vWD are often classified in 3 different types based on the clinical severity and quantity and multimere size of von Willebrand factor. Type I is characterized by low plasma vWF concentrations and mild to moderate bleeding symptoms. Type II disorder is characterised by qualitative abnormalities of the vWF protein and moderate to severe bleeding. Type III is the most severe form of vWD with no detectable or a severe quantitative deficiency of vWF.

Species-specific name: see also OMIA 001057-9615 : Von Willebrand disease I in Canis lupus familiaris, OMIA 001339-9615 : Von Willebrand disease II in Canis lupus familiaris and OMIA 001058-9615 : Von Willebrand disease III in Canis lupus familiaris

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001056-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Haginoya, S., Thomovsky, E.J., Johnson, P.A., Brooks, A.C. :
Clinical assessment of primary hemostasis: A review. Top Companion Anim Med :100818, 2023. Pubmed reference: 37673175. DOI: 10.1016/j.tcam.2023.100818.
2017 Keeshen, T.P., Case, J.B., Runge, J.J., Singh, A., Mayhew, P.D., Steffey, M.A., Culp, W.T.N. :
Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012-2014). J Am Vet Med Assoc 251:1053-1058, 2017. Pubmed reference: 29035661. DOI: 10.2460/javma.251.9.1053.
2010 Mattoso, C.R., Takahira, R.K., Beier, S.L., Ara├║jo, J.P., Corrente, J.E. :
Prevalence of von Willebrand disease in dogs from Sao Paulo State, Brazil. J Vet Diagn Invest 22:55-60, 2010. Pubmed reference: 20093683. DOI: 10.1177/104063871002200109.
2009 Burgess, H.J., Woods, J.P., Abrams-Ogg, A.C., Wood, R.D. :
Evaluation of laboratory methods to improve characterization of dogs with von Willebrand disease. Can J Vet Res 73:252-259, 2009. Pubmed reference: 20046626.
Nichols, TC., Dillow, AM., Franck, HW., Merricks, EP., Raymer, RA., Bellinger, DA., Arruda, VR., High, KA. :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J 50:144-67, 2009. Pubmed reference: 19293459.
2005 Heseltine, JC., Panciera, DL., Troy, GC., Monroe, WE., Brooks, MB., Feldman, BF. :
Effect of levothyroxine administration on hemostatic analytes in Doberman Pinschers with von Willebrand disease. J Vet Intern Med 19:523-7, 2005. Pubmed reference: 16095169.
2000 Lobetti, R.G., Dippenaar, T. :
Von Willebrand's disease in the German shepherd dog Journal of the South African Veterinary Medical Association 71:118-121, 2000.
1999 Applewhite, A.A., Wilkens, B.E., McDonald, D.E., Radasch, R.M., Barstad, R.D. :
Potential central nervous system complications of von Willebrand's disease Journal of the American Animal Hospital Association 35:423-429, 1999. Pubmed reference: 10493419.
Brooks, M. :
Hereditary bleeding disorders in dogs and cats Veterinary Medicine 94:555-564, 1999.
Schwarz, H.P., Dorner, F., Mitterer, A., Mundt, W., Schlokat, U., Pichler, L., Turecek, P.L. :
Preclinical evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Wiener Klinische Wochenschrift 111:181-191, 1999. Pubmed reference: 10226348.
Venta, P.J., Vidal, M. :
MspI RSP in exon 42 of the canine von Willebrand factor (VWF) gene Animal Genetics 30:229, 1999. Pubmed reference: 10442993.
1998 Brewer, G.J. :
Von Willebrand disease DNA testing Canine Practice 23:27-28, 1998.
Degopegui, R.R., Feldman, B.F. :
Acquired and inherited platelet dysfunction in small animals Compendium on Continuing Education for the Practicing Veterinarian 20:1039 ff., 1998.
Ray, J., Brooks, M.B., Suh, Y., Ray, K. :
A PCR-RFLP marker in canine von willebrand factor gene (vwf) Animal Genetics 29:406-407, 1998. Pubmed reference: 9800340.
Schwarz, H.P., Dorner, F., Mitterer, A., Mundt, W., Schlokat, U., Pichler, L., Turecek, P.L. :
Evaluation of recombinant von Willebrand factor in a canine model of von Willebrand disease Haemophilia 4:53-62, 1998. Pubmed reference: 10028320.
1997 Arnold, S., Muller, A., Binder, H., Meyers, K., Giger, U. :
Plasma von-willebrand-factor concentrations in bernese mountain dogs [German] Schweizer Archiv fur Tierheilkunde 139:177-182, 1997. Pubmed reference: 9173518.
Stokol, T., Trepanier, L., Parry, B.W., Finnin, B.C. :
Pharmacokinetics of von Willebrand factor and factor VIII in canine von-Willebrand-disease and haemophilia A Research in Veterinary Science 63:23-27, 1997. Pubmed reference: 9368952.
Turecek, P.L., Gritsch, H., Pichler, L., Auer, W., Fischer, B., Mitterer, A., Mundt, W., Schlokat, U., Dorner, F., Erinkman, H.J.M., Vanmourik, J.A., Schwarz, H.P. :
In vivo characterization of recombinant von willebrand factor in dogs with von-willebrand-disease Blood 90:3555-3567, 1997. Pubmed reference: 9345039.
1996 Anon. :
Test identifies carriers of von Willebrands disease American Journal of Veterinary Research 57:1521, 1996.
Brooks, M., Raymond, S., Catalfamo, J. :
Severe, recessive von Willebrands disease in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:926 ff., 1996.
Brooks, M., Raymond, S., Catalfamo, J. :
Plasma von Willebrand factor antigen concentration as a predictor of von Willebrands disease status in German Wirehaired Pointers Journal of the American Veterinary Medical Association 209:930 ff., 1996.
Holmes, N.G., Shaw, S.C., Dickens, H.F., Coombes, L.M., Ryder, E.J., Littlewood, J.D., Binns, M.M. :
Von willebrands disease in UK Dobermanns - possible correlation of a polymorphic DNA marker with disease status Journal of Small Animal Practice 37:307-308, 1996. Pubmed reference: 8840249.
Moser, J., Meyers, K.M., Meinkoth, J.H., Brassard, J.A. :
Temporal variation and factors affecting measurement of canine von willebrand factor American Journal of Veterinary Research 57:1288-1293, 1996. Pubmed reference: 8874720.
Moser, J., Meyers, K.M., Russon, R.H. :
Inheritance of von willebrand factor deficiency in doberman pinschers Journal of the American Veterinary Medical Association 209:1103 ff., 1996.
Thomas, J.S. :
von Willebrand's disease in the dog and cat. Vet Clin North Am Small Anim Pract 26:1089-110, 1996. Pubmed reference: 8863392.
Thomas, J.S. :
Von Willebrand's disease in the dog and cat Veterinary Clinics of North America - Small Animal Practice 26:1089 ff., 1996.
1995 Clark, P., Parry, B.W. :
Survey of Irish Wolfhounds in Australia for von Willebrands disease Australian Veterinary Journal 72:393, 1995. Pubmed reference: 8599574.
Dunn, K.J., Nicholls, P.K., Dunn, J.K., Herrtage, M.E. :
Intracranial haemorrhage in a dobermann puppy with von Willebrand's disease Veterinary Record 136:635-636, 1995. Pubmed reference: 7571271.
Slappendel, R.J. :
Von Willebrand's disease in Dutch Kooiker dogs Veterinary Quarterly 17:S21-S22, 1995. Pubmed reference: 7571294.
Stokol, T., Parry, B.W., Mansell, P.D. :
Von willebrands disease in scottish terriers in australia Australian Veterinary Journal 72:404-407, 1995. Pubmed reference: 8929184.
Stokol, T., Parry, B.W. :
Stability of canine factor VIII and von Willebrand factor antigen concentration in the frozen state Research in Veterinary Science 59:156-159, 1995. Pubmed reference: 8525106.
Stokol, T., Parry, B.W., Mansell, P.D. :
von Willebrand's disease in Dobermann dogs in Australia Australian Veterinary Journal 72:257-262, 1995. Pubmed reference: 8534229.
Stokol, T., Parry, B.W. :
Stability of von Willebrand factor and factor VIII in canine cryoprecipitate under various conditions of storage Research in Veterinary Science 59:152-155, 1995. Pubmed reference: 8525105.
1994 Brassard, J.A., Meyers, K.M. :
von Willebrand factor is not altered in azotemic dogs with prolonged bleeding time Journal of Laboratory and Clinical Medicine 124:55-62, 1994. Pubmed reference: 8035104.
Ching, Y.N.L.H., Meyers, K.M., Brassard, J.A., Wardrop, K.J. :
Effect of Cryoprecipitate and Plasma on Plasma Vonwillebrand Factor Multimeters and Bleeding Time in Doberman-Pinschers with Type-I Vonwillebrands Disease American Journal of Veterinary Research 55:102-110, 1994. Pubmed reference: 8141483.
Locke, K. :
Severe Haemorrhage in Dobermann Dogs with Vonwillebrand's Disease and Its Control During Surgery Australian Veterinary Journal 71:263, 1994. Pubmed reference: 7986192.
1993 Nichols, T.C., Bellinger, D.A., Reddick, R.L., Smith, S.V., Koch, G.G., Davis, K., Sigman, J., Brinkhous, K.M., Griggs, T.R., Read, M.S. :
The Roles of von Willebrand Factor and Factor-VIII in Arterial Thrombosis - Studies in Canine von Willebrand Disease and Hemophilia-A Blood 81:2644-2651, 1993. Pubmed reference: 8490173.
Stokol, T., Parry, B.W. :
Canine Vonwillebrand Disease - A Review Australian Veterinary Practitioner 23:94-103, 1993.
1992 Benson, R.E., Catalfamo, J.L., Dodds, W.J. :
A Multispecies Enzyme-Linked Immunosorbent Assay for Von Willebrand's Factor Journal of Laboratory and Clinical Medicine 119:420-427, 1992. Pubmed reference: 1583394.
Brooks, M. :
Management of canine von Willebrand's disease. Probl Vet Med 4:636-46, 1992. Pubmed reference: 1472774.
Brooks, M., Dodds, W.J., Raymond, S.L. :
Epidemiologic Features of von Willebrand's Disease in Doberman-Pinschers, Scottish Terriers, and Shetland Sheepdogs - 260 Cases (1984-1988) Journal of the American Veterinary Medical Association 200:1123-1127, 1992. Pubmed reference: 1607320.
Huss, B.T., Ettinger, S.J. :
Visceral Leishmaniasis, Rocky Mountain Spotted Fever, and Vonwillebrand's Disease in a Giant Schnauzer Journal of the American Animal Hospital Association 28:221-225, 1992.
Mansell, P.D., Parry, B.W. :
Changes in Factor 8 Activity and Vonwillebrand-Factor Antigen Concentration with Age in Dogs British Veterinary Journal 148:329-337, 1992. Pubmed reference: 1498645. DOI: 10.1016/0007-1935(92)90085-F.
Mansell, P.D., Parry, B.W. :
Effect of Acepromazine, Xylazine and Thiopentone on Factor VIII Activity and Vonwillebrand Factor Antigen Concentration in Dogs Australian Veterinary Journal 69:187-190, 1992. Pubmed reference: 1530553.
Meyers, K.M., Wardrop, K.J., Meinkoth, J. :
Canine von Willebrand's Disease - Pathobiology, Diagnosis, and Short-Term Treatment Compendium on Continuing Education for the Practicing Veterinarian 14:13, 1992.
Slappendel, R.J., Frielink, R.A.J., Mol, J.A., Noordzij, A., Hamer, R. :
An Enzyme-Linked Immunosorbent Assay (ELISA) for Vonwillebrand Factor Antigen (vWf-Ag) in Canine Plasma Veterinary Immunology and Immunopathology 33:145-154, 1992. Pubmed reference: 1632075.
1991 Benson, R.E., Catalfamo, J.L., Brooks, M., Dodds, W.J. :
A Sensitive Immunoassay for von Willebrand Factor Journal of Immunoassay 12:371-390, 1991. Pubmed reference: 1939665. DOI: 10.1080/01971529108055078.
Brassard, J.A., Meyers, K.M. :
Evaluation of the Buccal Bleeding Time and Platelet Glass Bead Retention As Assays of Hemostasis in the Dog - The Effects of Acetylsalicylic Acid, Warfarin and Vonwillebrand Factor Deficiency Thrombosis and Haemostasis 65:191-195, 1991. Pubmed reference: 2053106.
Brinkhous, K.M., Reddick, R.L., Read, M.S., Nichols, T.C., Bellinger, D.A., Griggs, T.R. :
von Willebrand Factor and Animal Models - Contributions to Gene Therapy, Thrombotic Thrombocytopenic Purpura, and Coronary Artery Thrombosis Mayo Clinic Proceedings 66:733-742, 1991. Pubmed reference: 2072761.
Johnstone, I.B., Crane, S. :
Quantitation of Canine Plasma Von Willebrand Factor Antigen Using a Commercial Enzyme-Linked Immunosorbent Assay Canadian Journal of Veterinary Research-Revue Canadienne de Recherche Veterinaire 55:11-14, 1991. Pubmed reference: 1884278.
Johnstone, I.B., Keen, J., Halbert, A., Crane, S. :
Stability of Factor-VIII and Vonwillebrand Factor in Canine Blood Samples During Storage Canadian Veterinary Journal-Revue Veterinaire Canadienne 32:173-175, 1991.
Mansell, P.D., Parry, B.W. :
Stability of Canine Factor-VIII Activity and Vonwillebrand Factor Antigen Concentration Invitro Research in Veterinary Science 51:313-316, 1991. Pubmed reference: 1780587.
Parker, M.T., Turrentine, M.A., Johnson, G.S. :
Von Willebrand Factor in Lysates of Washed Canine Platelets American Journal of Veterinary Research 52:119-125, 1991. Pubmed reference: 2021239.
1990 Avgeris, S., Lothrop, C.D., Mcdonald, T.P. :
Plasma Vonwillebrand Factor Concentration and Thyroid Function in Dogs Journal of the American Veterinary Medical Association 196:921-924, 1990. Pubmed reference: 2107158.
Dueland, R.T., Wagner, S.D., Parker, R.B. :
Vonwillebrand Heterotopic Osteochondrofibrosis in Doberman Pinschers - 5 Cases (1980-1987) Journal of the American Veterinary Medical Association 197:383-388, 1990. Pubmed reference: 2118129.
Meyers, K.M., Wardrop, K.J., Helmick, C., White, F. :
Vonwillebrand Factor Is Present in the Vascular Endothelium from Normal Dogs and from Doberman-Pinscher Dogs with a Plasma Vonwillebrand Factor Deficiency Thrombosis Research 57:109-116, 1990. Pubmed reference: 2405539.
Meyers, K.M., Wardrop, K.J., Dodds, W.J., Brassard, J. :
Effect of Exercise, Ddavp, and Epinephrine on the Factor VIII- C Vonwillebrand Factor Complex in Normal Dogs and Vonwillebrand Factor Deficient Doberman-Pinscher Dogs Thrombosis Research 57:97-108, 1990. Pubmed reference: 2105540.
Raymond, S.L., Jones, D.W., Brooks, M.B., Dodds, W.J. :
Clinical and Laboratory Features of a Severe Form of Vonwillebrand Disease in Shetland Sheepdogs Journal of the American Veterinary Medical Association 197:1342-1346, 1990. Pubmed reference: 2266049.
1989 Brinkhous, K.M., Hedner, U., Garris, J.B., Diness, V., Read, M.S. :
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A 86:1382-6, 1989. Pubmed reference: 2784006.
1988 Johnson, G.S., Turrentine, M.A., Kraus, K.H. :
Canine von Willebrand's disease. A heterogeneous group of bleeding disorders Veterinary Clinics of North America, Small Animal Practice 18:195-229, 1988.
Johnson, G.S., Turrentine, M.A., Kraus, K.H. :
Canine von Willebrand's disease. A heterogeneous group of bleeding disorders. Vet Clin North Am Small Anim Pract 18:195-229, 1988. Pubmed reference: 3282380. DOI: 10.1016/s0195-5616(88)50017-7.
1986 Randolph, J.F., Center, S.A., Dodds, W.J. :
Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs. Cornell Vet 76:3-10, 1986. Pubmed reference: 3484442.
1984 Dodds, W.J. :
Von Willebrand's disease in dogs. Mod Vet Pract 65:681-6, 1984. Pubmed reference: 6332976.
1981 Johnstone, I.B., Crane, S. :
Von Willebrand's disease in two families of Doberman Pinschers Canadian Veterinary Journal 22:239-243, 1981.
1978 Read, M.S., Shermer, R.W., Brinkhous, K.M. :
Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor. Proc Natl Acad Sci U S A 75:4514-8, 1978. Pubmed reference: 309134.
1977 Dodds, W.J. :
Porcine and canine von Willebrand's disease Comparative Pathology Bulletin 9:2-, 1977.
1975 Dodds, W.J. :
Further studies of canine von Willebrand's disease. Blood 45:221-30, 1975. Pubmed reference: 1078981.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 21 Apr 2022